scholarly journals Urinary Cysteine-Rich Protein 61 and Trefoil Factor 3 as Diagnostic Biomarkers for Colorectal Cancer

2019 ◽  
Vol 12 (3) ◽  
pp. 539-544 ◽  
Author(s):  
Takaya Shimura ◽  
Hiroyasu Iwasaki ◽  
Mika Kitagawa ◽  
Masahide Ebi ◽  
Tamaki Yamada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Trefoil Factor ◽  
Diagnostic Biomarkers ◽  
Cysteine Rich Protein ◽  
Trefoil Factor 3

Su1058 – Potential of Urinary Cysteine-Rich Protein 61 and Trefoil Factor 3 As Novel Biomarkers for the Detection of Colorectal Cancer

2019 ◽  
Vol 156 (6) ◽  
pp. S-498
Author(s):  
Takaya Shimura ◽  
Hiroyasu Iwasaki ◽  
Masahide Ebi ◽  
Tamaki Yamada ◽  
Tomonori Yamada ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Trefoil Factor ◽  
Cysteine Rich Protein ◽  
Trefoil Factor 3 ◽  
Novel Biomarkers

scholarly journals Serum Trefoil Factor 3 as a Protein Biomarker for the Diagnosis of Colorectal Cancer

2016 ◽  
Vol 16 (4) ◽  
pp. 440-445 ◽  
Author(s):  
Qiang Li ◽  
Keke Wang ◽  
Chang Su ◽  
Jieyu Fang
Keyword(s):  
Colorectal Cancer ◽  
Diagnostic Accuracy ◽  
Receiver Operating Characteristic ◽  
Carcinoembryonic Antigen ◽  
Operating Characteristic ◽  
Tnm Stage ◽  
Healthy Controls ◽  
Trefoil Factor ◽  
Trefoil Factor 3 ◽  
Receiver Operating

Colorectal cancer is one of the most frequent causes of cancer-related deaths worldwide. Thus, there is a need for timely diagnosis and effective treatment. Our aim in the present study was to detect the serum level of trefoil factor 3 protein and evaluate the diagnostic accuracy of trefoil factor 3 in patients with colorectal cancer. We collected serum samples from 204 participants (127 patients with colorectal cancer, 35 patients with polyps, and 42 healthy controls). The levels of serum trefoil factor 3 and carcinoembryonic antigen expression were measured by enzyme-linked immunosorbent assay. Receiver operating characteristic curves were plotted to calculate the diagnostic accuracy of trefoil factor 3 in patients with colorectal cancer. The serum levels of trefoil factor 3 in patients with colorectal cancer (6.66 ± 2.4 ng/mL; P < .00l) and polyps (3.86 ± 1.3 ng/mL; P < .00l) were significantly increased compared to healthy controls (2.09 ± 1.0 ng/mL). Moreover, the area under the receiver operating characteristic curve for trefoil factor 3 was greater than carcinoembryonic antigen (0.889 vs 0.715). At a cutoff value of 5.591 ng/mL, the diagnostic sensitivity, specificity, and likelihood ratio of serum trefoil factor 3 for colorectal cancer was 74.2%, 94.8%, and 14.25, respectively. Furthermore, the serum trefoil factor 3 levels in early colorectal cancer (TNM stage I, 3.67 ± 1.27 ng/mL) were significantly increased compared to healthy controls ( P < .001); however, there was no significant difference compared to patients with polyps ( P = .576). We observed that the serum trefoil factor 3 levels decreased after surgery (6.66 ± 2.4 vs 4.48 ± 1.80 ng/mL; P < .001). In addition, high serum trefoil factor 3 levels were associated with poor tumor differentiation and clinical TNM stage ( P < .05). In conclusion, serum trefoil factor 3 is a promising biomarker for the diagnosis of colorectal cancer and prognosis of patients.

scholarly journals Expression of trefoil factor 3 is decreased in colorectal cancer

2020 ◽  
Vol 45 (1) ◽  
pp. 254-264
Author(s):  
Ingrid Espinoza ◽  
Sumit Agarwal ◽  
Amit Reddy ◽  
Veena Shenoy ◽  
Charulochana Subramony ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Trefoil Factor ◽  
Trefoil Factor 3

scholarly journals The value of trefoil factor 3 expression in predicting the long-term outcome and early recurrence of colorectal cancer

2014 ◽  
Vol 46 (2) ◽  
pp. 563-568 ◽  
Author(s):  
KIYOTO MORITO ◽  
JUN NAKAMURA ◽  
YOSHIHIKO KITAJIMA ◽  
KEITA KAI ◽  
TOMOKAZU TANAKA ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Early Recurrence ◽  
Trefoil Factor ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Trefoil Factor 3

scholarly journals Oncogenic Functions and Clinical Significance of Circular RNAs in Colorectal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (14) ◽  
pp. 3395
Author(s):  
Maria Radanova ◽  
Galya Mihaylova ◽  
Neshe Nazifova-Tasinova ◽  
Mariya Levkova ◽  
Oskan Tasinov ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Drug Targets ◽  
Clinicopathological Characteristics ◽  
Circular Rnas ◽  
Diagnostic Biomarkers ◽  
The Third ◽  
Current Review ◽  
Important Challenge ◽  
Prediction Of Metastasis

Colorectal cancer (CRC) is ranked as the second most commonly diagnosed disease in females and the third in males worldwide. Therefore, the finding of new more reliable biomarkers for early diagnosis, for prediction of metastasis, and resistance to conventional therapies is an important challenge in overcoming the disease. The current review presents circular RNAs (circRNAs) with their unique features as potential prognostic and diagnostic biomarkers in CRC. The review highlights the mechanism of action and the role of circRNAs with oncogenic functions in the CRC as well as the association between their expression and clinicopathological characteristics of CRC patients. The comprehension of the role of oncogenic circRNAs in CRC pathogenesis is growing rapidly and the next step is using them as suitable new drug targets in the personalized treatment of CRC patients.

scholarly journals PI3K/Akt Signaling Pathway in the Basolateral Amygdala Mediates the Rapid Antidepressant-like Effects of Trefoil Factor 3

2012 ◽  
Vol 37 (12) ◽  
pp. 2671-2683 ◽  
Author(s):  
Hai-Shui Shi ◽  
Wei-Li Zhu ◽  
Jian-Feng Liu ◽  
Yi-Xiao Luo ◽  
Ji-Jian Si ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Basolateral Amygdala ◽  
Akt Signaling ◽  
Trefoil Factor ◽  
Akt Signaling Pathway ◽  
Trefoil Factor 3

167: Role of trefoil factor-3 peptide (TFF3) in prostate cancer progression

2014 ◽  
Vol 50 ◽  
pp. S37 ◽  
Author(s):  
M. Nowak ◽  
C. Merz ◽  
A. Von Maessenhausen ◽  
W. Vogel ◽  
D. Boehm ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Progression ◽  
Prostate Cancer Progression ◽  
Trefoil Factor ◽  
Trefoil Factor 3
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