scholarly journals Veratramine suppresses human HepG2 liver cancer cell growth in vitro and in vivo by inducing autophagic cell death

2020 ◽  
Vol 44 (2) ◽  
pp. 477-486
Author(s):  
Linlin Yin ◽  
Yonghui Xia ◽  
Ping Xu ◽  
Wenli Zheng ◽  
Yuanyuan Gao ◽  
...  
Keyword(s):  
Cell Death ◽  
Cell Growth ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Autophagic Cell Death ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo

2013 ◽  
Vol 45 (3) ◽  
pp. 213-219 ◽  
Author(s):  
L. Wang ◽  
J. Feng ◽  
L. Da ◽  
Y. Li ◽  
Z. Li ◽  
...  
Keyword(s):  
Cell Growth ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth

Inhibiting effect of MicroRNA-3619-5p/PSMD10 axis on liver cancer cell growth in vivo and in vitro

Life Sciences ◽  
2020 ◽  
Vol 254 ◽  
pp. 117632 ◽  
Author(s):  
Peipei Hao ◽  
Fengming Yue ◽  
Xian Xian ◽  
Qian Ren ◽  
Huixian Cui ◽  
...  
Keyword(s):  
Cell Growth ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth ◽  
Inhibiting Effect

scholarly journals MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivo

Oncogene ◽  
2011 ◽  
Vol 31 (28) ◽  
pp. 3357-3369 ◽  
Author(s):  
X-X He ◽  
Y Chang ◽  
F-Y Meng ◽  
M-Y Wang ◽  
Q-H Xie ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Growth ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Marine Bacterial Polysaccharide EPS11 Inhibits Cancer Cell Growth and Metastasis via Blocking Cell Adhesion and Attenuating Filiform Structure Formation

Marine Drugs ◽  
2019 ◽  
Vol 17 (1) ◽  
pp. 50 ◽  
Author(s):  
Ju Wang ◽  
Ge Liu ◽  
Weiping Ma ◽  
Zhongxia Lu ◽  
Chaomin Sun
Keyword(s):  
Cell Death ◽  
Cell Adhesion ◽  
Cell Growth ◽  
Liver Cancer ◽  
Structure Formation ◽  
Cancer Cell ◽  
Bacterial Polysaccharide ◽  
Cancer Cell Growth ◽  
And Migration

Our previous results suggested that EPS11, a novel marine bacterial polysaccharide, might be a potential drug candidate for human non-small cell lung carcinoma treatment. In this study, we further investigate the anticancer mechanisms against liver cancer and the anti-metastatic effects in vivo of EPS11. Firstly, we found that EPS11 exerts cytotoxic effects via blocking cell adhesion and destroying filiform structure formation in Huh7.5 cells. Moreover, mass spectrometry-based proteomic analysis of EPS11-treated Huh7.5 cells revealed that expression of many adhesion-related proteins was significantly changed. It is noteworthy that the expression of CD99, a key factor related to cell adhesion, migration and cell death, is remarkably down-regulated after EPS11 treatment. Importantly, over-expression of CD99 partly rescues cell death rate, and improves cell adhesion and migration ability in Huh7.5 treated by EPS11. Thus, we propose that CD99 is a potential action target of EPS11, inhibiting cancer cell proliferation, adhesion and migration. Notably, administration of EPS11 simultaneously with tumor induction evidently reduces tumor nodule formation in the lungs, which strongly indicates that EPS11 has anti-metastatic effects in vivo. Taken together, our results suggest that EPS11 inhibits liver cancer cell growth via blocking cell adhesion and attenuating filiform structure formation, and has potential as an anti-cancer drug, targeting metastasis of cancer cells, in the future.

794: Valproic Acid Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 257-257
Author(s):  
Jennifer Sung ◽  
Qinghua Xia ◽  
Wasim Chowdhury ◽  
Shabana Shabbeer ◽  
Michael Carducci ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Valproic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth

scholarly journals HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Bioinformatics Analyses

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

microRNA 21-mediated suppression of sprouty1 by Pokemon affects liver cancer cell growth and proliferation

2013 ◽  
Vol 114 (7) ◽  
pp. 1625-1633 ◽  
Author(s):  
Xiu-Li Jin ◽  
Qin-Sheng Sun ◽  
Feng Liu ◽  
Hong-Wei Yang ◽  
Min Liu ◽  
...  
Keyword(s):  
Cell Growth ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth ◽  
Cell Growth And Proliferation
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