scholarly journals Cryopreserved biopsy tissues of rectal cancer liver metastasis for assessment of anticancer drug response in�vitro and in�vivo

2019 ◽  
Author(s):  
Yuan Zhang ◽  
Wei‑Jian Huang ◽  
Qiu‑Rui Yang ◽  
Hong‑Dan Zhang ◽  
Xue‑Jing Zhu ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Liver Metastasis ◽  
Anticancer Drug ◽  
Drug Response ◽  
Anticancer Drug Response

scholarly journals Impact of multicellular tumor spheroids as an in vivo-like tumor model on anticancer drug response

2016 ◽  
Vol 48 (6) ◽  
pp. 2295-2302 ◽  
Author(s):  
BIANCA GALATEANU ◽  
ARIANA HUDITA ◽  
CAROLINA NEGREI ◽  
RODICA-MARIANA ION ◽  
MARIETA COSTACHE ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Drug Response ◽  
Tumor Model ◽  
Multicellular Tumor Spheroids ◽  
Tumor Spheroids ◽  
Anticancer Drug Response

In Vitro and In Vivo Investigations into the Carbene Copper Bromide Anticancer Drug Candidate WBC4

2014 ◽  
Vol 11 (7) ◽  
pp. 825-832 ◽  
Author(s):  
Wolfgang Walther ◽  
Iduna Fichtner ◽  
Frauke Hackenberg ◽  
Wojciech Streciwilk ◽  
Matthias Tacke
Keyword(s):  
Anticancer Drug ◽  
Drug Candidate ◽  
Copper Bromide

scholarly journals LncRNA MIR17HG promotes colorectal cancer liver metastasis by mediating a glycolysis-associated positive feedback circuit

Oncogene ◽  
2021 ◽  
Author(s):  
Senlin Zhao ◽  
Bingjie Guan ◽  
Yushuai Mi ◽  
Debing Shi ◽  
Ping Wei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Liver Metastasis ◽  
Positive Feedback ◽  
Feedback Loop ◽  
Metastatic Tumor ◽  
Feedback Circuit ◽  
Colorectal Cancer Liver Metastasis ◽  
Positive Feedback Circuit

AbstractGlycolysis plays a crucial role in reprogramming the metastatic tumor microenvironment. A series of lncRNAs have been identified to function as oncogenic molecules by regulating glycolysis. However, the roles of glycolysis-related lncRNAs in regulating colorectal cancer liver metastasis (CRLM) remain poorly understood. In the present study, the expression of the glycolysis-related lncRNA MIR17HG gradually increased from adjacent normal to CRC to the paired liver metastatic tissues, and high MIR17HG expression predicted poor survival, especially in patients with liver metastasis. Functionally, MIR17HG promoted glycolysis in CRC cells and enhanced their invasion and liver metastasis in vitro and in vivo. Mechanistically, MIR17HG functioned as a ceRNA to regulate HK1 expression by sponging miR-138-5p, resulting in glycolysis in CRC cells and leading to their invasion and liver metastasis. More interestingly, lactate accumulated via glycolysis activated the p38/Elk-1 signaling pathway to promote the transcriptional expression of MIR17HG in CRC cells, forming a positive feedback loop, which eventually resulted in persistent glycolysis and the invasion and liver metastasis of CRC cells. In conclusion, the present study indicates that the lactate-responsive lncRNA MIR17HG, acting as a ceRNA, promotes CRLM through a glycolysis-mediated positive feedback circuit and might be a novel biomarker and therapeutic target for CRLM.

D2O-Probed Raman Microspectroscopy Distinguishes the Metabolic Dynamics of Macromolecules in Organellar Anticancer Drug Response

2021 ◽  
Vol 93 (4) ◽  
pp. 2125-2134
Author(s):  
Maryam Hekmatara ◽  
Mohammadhadi Heidari Baladehi ◽  
Yuetong Ji ◽  
Jian Xu
Keyword(s):  
Anticancer Drug ◽  
Drug Response ◽  
Raman Microspectroscopy ◽  
Anticancer Drug Response

In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR

2016 ◽  
Vol 14 (2) ◽  
pp. 125-134 ◽  
Author(s):  
Wolfgang Walther ◽  
Oyinlola Dada ◽  
Cillian O’Beirne ◽  
Ingo Ott ◽  
Goar Sánchez-Sanz ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Gold Chloride ◽  
Drug Candidates
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