scholarly journals Fabrication of psoralen-loaded lipid-polymer hybrid nanoparticles and their reversal effect on drug resistance of cancer cells

2018 ◽  
Author(s):  
Yueling Yuan ◽  
Peter Chiba ◽  
Tiange Cai ◽  
Richard Callaghan ◽  
Li Bai ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Hybrid Nanoparticles ◽  
Reversal Effect ◽  
Polymer Hybrid

Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

2018 ◽  
Vol 48 ◽  
pp. 96-105 ◽  
Author(s):  
Hannaneh monirinasab ◽  
Hamed Asadi ◽  
Kobra Rostamizadeh ◽  
Abdolreza Esmaeilzadeh ◽  
Malihe Khodaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Reversal Effect of Stephania Tetrandra-Containing Chinese Herb Formula SENL on Multidrug Resistance in Lung Cancer Cell Line SW1573/2R120

2010 ◽  
Vol 38 (02) ◽  
pp. 401-413 ◽  
Author(s):  
Meng Xu ◽  
Liang-He Sheng ◽  
Xi-Hai Zhu ◽  
Shi-Bin Zeng ◽  
Guo-Jun Zhang
Keyword(s):  
Lung Cancer ◽  
Drug Resistance ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Reversal Effect

This research is aimed on reversing multidrug resistance (MDR) of chemotherapy in lung cancer. According to our previous research, chemotherapeutic drugs resistance in lung cancer is mainly due to high expression of multidrug resistance-associated protein (MRP) gene and activation of caspases. The effect of stephania tetrandra-containing Chinese herbal formula, namely Supplement Energy and Nourish Lung (SENL), is effective in enhancing efficacy and reducing toxicity of chemotherapy in lung cancer. However, the underlying mechnism is largely unknown. To understand whether and how SENL herbs function on multidrug-resistance lung cancer cells, we treated a multidrug resistance lung cancer cell line, SW1573/2R120 with SENL herbs alone or together with a chemotherapeutic drug, Adriamycin (ADM). We observed that SENL herbs had a significant synergistic effect with ADM in inhibiting the growth of SW1573/2R120 cells. SENL alone and particularly together with ADM could significantly increase cell apoptotic death via mitochondria- and caspase-dependent pathway. Furthermore, we showed that SENL herbs could reverse drug resistance of lung cancer cells by decreasing MRP expression and increasing accumulation of intracellular ADM, which in turn increase the sensitivity of cancer cells to ADM. Taken together, the mechanism underlying reversal effect of drug resistance by SENL treatment was reported here and further systematical investigation on SENL herbs may lead to solve drug resistance in lung cancer chemotherapy.

Lipid–polymer hybrid nanoparticles for synergistic drug delivery to overcome cancer drug resistance

2017 ◽  
Vol 41 (4) ◽  
pp. 1518-1525 ◽  
Author(s):  
Shao-Qi Zeng ◽  
Yi-Zhen Chen ◽  
Yong Chen ◽  
Hong Liu
Keyword(s):  
Drug Delivery ◽  
Drug Resistance ◽  
Hybrid Nanoparticles ◽  
Cancer Drug ◽  
Chemotherapeutic Drug ◽  
Cancer Drug Resistance ◽  
Polymer Hybrid ◽  
Tumor Drug Resistance

Co-delivery of a chemotherapeutic drug and a drug resistance inhibitor by lipid–polymer hybrid nanoparticles can effectively overcome tumor drug resistance.

Redox-triggered activation of nanocarriers for mitochondria-targeting cancer chemotherapy

Nanoscale ◽  
2017 ◽  
Vol 9 (43) ◽  
pp. 17044-17053 ◽  
Author(s):  
Wei Zhou ◽  
Hui Yu ◽  
Liu-Jie Zhang ◽  
Bo Wu ◽  
Cai-Xia Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Chemotherapy ◽  
Hybrid Nanoparticles ◽  
Highly Efficient ◽  
Polymer Hybrid ◽  
Mitochondria Targeting

The mitochondria-targeting of lipid–polymer hybrid nanoparticles can be activated by a redox-signal in cancer cells for highly efficient cancer chemotherapy.

Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16931-16939 ◽  
Author(s):  
Zhenbao Liu ◽  
Huanzhe Zhao ◽  
Lingyun He ◽  
Yao Yao ◽  
Yanbin Zhou ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cellular Uptake ◽  
Targeted Delivery ◽  
Polymer Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Density Dependent ◽  
Polymer Hybrid ◽  
Muc1 Aptamer

In this work, MUC1 aptamer (designated S2.2) modified and vinorelbine (VRL) loaded lipid-polymer hybrid nanoparticles (Apt-VRL-NPs) were prepared.

scholarly journals Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to Doxorubicin by inhibiting epithelial mesenchymal transition

2021 ◽  
Author(s):  
Tengteng Zou ◽  
Meng Lan ◽  
Lihong Li ◽  
Tiange Cai ◽  
Yu Cai
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Hybrid Nanoparticles ◽  
Apoptosis Resistance ◽  
Mesenchymal Transition ◽  
Mcf 7

Abstract Background The role of epithelial mesenchymal transition (EMT) involved in breast cancer metastasis and chemoresistance has been increasingly recognized. However, it’s necessary to search for more effective strategies to inhibit EMT thereby increase the sensitivity of breast cancer cells to chemotherapy drugs. Emodin has a potential in overcoming tumor drug resistance and restraining the development of EMT, but the poor internalization into breast cancer cells limited the application. Results MCF-7/ADR cells have more EMT characteristics than MCF-7 cell. EMT in MCF-7/ADR cells promotes the development of drug resistance via apoptosis resistance and facilitating the expression of P-gp. The anti-cancer effect of DOX enhanced by the decreasing of drug resistance protein P-gp and apoptosis related proteins after EMT inhibited in MCF-7/ADR cells. E-PLNs increase the cellular uptake of EMO and restore DOX sensitivity in MCF-7/ADR cells by inhibiting EMT. Conclusion E-PLNs inhibit EMT to enhance the sensitivity of breast cancer to DOX. The combination of E-PLNs and DOX can improve the efficacy of DOX in the treatment of breast cancer, which provides a new method to prevent or delay clinical drug resistance.

scholarly journals Lipid-polymer hybrid nanoparticles carrying doxorubicin and edelfosine combo for synergistic anticancer effect against drug-resistant Osteosarcoma

2020 ◽  
Author(s):  
Ping Yang ◽  
Lian Zhang ◽  
Tian Wang ◽  
Qi Liu ◽  
Jing Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Folate Receptor ◽  
Drug Loading ◽  
Hybrid Nanoparticles ◽  
Anticancer Efficacy ◽  
Targeted Nanoparticles ◽  
Polymer Hybrid ◽  
Multiple Drugs

Abstract In this study, we have prepared a novel folate receptor-targeted doxorubicin (DOX) and edelfosine (ET)-loaded lipid polymer hybrid nanoparticle to enhance the anticancer efficacy in osteosarcoma. The dual-drug loaded nanoparticles showed a nanosized morphology and physiological stability. The targeted nanoparticles showed enhanced cellular internalization and subcellular distribution in MG63 cancer cells compared to that of non-targeted nanoparticles. Among many ratios of DOX and ET, 1:1 ratiometric combinations of drugs were observed to be highly synergistic in killing the cancer cells. MTT assay and caspase-3/7 activity assay clearly showed the superior anticancer efficacy of DE-FPLN formulations in inducing the cancer cell death. In vitro results indicate that the co-administration of two drugs in a folic acid-targeted nanoparticle could potentially induce the apoptosis and cell death. In vivo results displayed the potency of tumor cell killing and significant suppression of tumor growth without any detectable side effects. The lipid polymer hybrid nanocarriers with multiple properties of high drug loading, sequential and ratiometric drug release, improved physiological stability, prolonged blood circulation, and tumor-specific targeting are promising for the delivery of multiple drugs in the treatment of osteosarcoma.

scholarly journals Emodin-loaded polymer-lipid hybrid nanoparticles enhance the sensitivity of breast cancer to doxorubicin by inhibiting epithelial–mesenchymal transition

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Tengteng Zou ◽  
Meng Lan ◽  
Fengjie Liu ◽  
Lihong Li ◽  
Tiange Cai ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Resistance ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Cancer Metastasis ◽  
Epithelial Mesenchymal Transition ◽  
Hybrid Nanoparticles ◽  
Apoptosis Resistance ◽  
Mesenchymal Transition ◽  
Mcf 7

Abstract Background The role of epithelial–mesenchymal transition (EMT) involved in breast cancer metastasis and chemoresistance has been increasingly recognized. However, it is necessary to search for more effective strategies to inhibit EMT thereby increase the sensitivity of breast cancer cells to chemotherapy drugs. Emodin has a potential in overcoming tumor drug resistance and restraining the development of EMT, but the poor internalization into breast cancer cells limited the application. Results MCF-7/ADR cells have more EMT characteristics than MCF-7 cell. EMT in MCF-7/ADR cells promotes the development of drug resistance via apoptosis resistance and facilitating the expression of P-gp. The anti-cancer effect of DOX enhanced by the decreasing of drug resistance protein P-gp and apoptosis-related proteins after EMT inhibited in MCF-7/ADR cells. E-PLNs increase the cellular uptake of EMO and restore DOX sensitivity in MCF-7/ADR cells by inhibiting EMT. Conclusion E-PLNs inhibit EMT to enhance the sensitivity of breast cancer to DOX. The combination of E-PLNs and DOX can improve the efficacy of DOX in the treatment of breast cancer, which provides a new method to prevent or delay clinical drug resistance.

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