Redox-triggered activation of nanocarriers for mitochondria-targeting cancer chemotherapy

Nanoscale ◽  
2017 ◽  
Vol 9 (43) ◽  
pp. 17044-17053 ◽  
Author(s):  
Wei Zhou ◽  
Hui Yu ◽  
Liu-Jie Zhang ◽  
Bo Wu ◽  
Cai-Xia Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cancer Chemotherapy ◽  
Hybrid Nanoparticles ◽  
Highly Efficient ◽  
Polymer Hybrid ◽  
Mitochondria Targeting

The mitochondria-targeting of lipid–polymer hybrid nanoparticles can be activated by a redox-signal in cancer cells for highly efficient cancer chemotherapy.

Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

2018 ◽  
Vol 48 ◽  
pp. 96-105 ◽  
Author(s):  
Hannaneh monirinasab ◽  
Hamed Asadi ◽  
Kobra Rostamizadeh ◽  
Abdolreza Esmaeilzadeh ◽  
Malihe Khodaei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Silencing ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Sirna Delivery ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid

Aptamer density dependent cellular uptake of lipid-capped polymer nanoparticles for polyvalent targeted delivery of vinorelbine to cancer cells

RSC Advances ◽  
2015 ◽  
Vol 5 (22) ◽  
pp. 16931-16939 ◽  
Author(s):  
Zhenbao Liu ◽  
Huanzhe Zhao ◽  
Lingyun He ◽  
Yao Yao ◽  
Yanbin Zhou ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Cellular Uptake ◽  
Targeted Delivery ◽  
Polymer Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Density Dependent ◽  
Polymer Hybrid ◽  
Muc1 Aptamer

In this work, MUC1 aptamer (designated S2.2) modified and vinorelbine (VRL) loaded lipid-polymer hybrid nanoparticles (Apt-VRL-NPs) were prepared.

scholarly journals Lipid-polymer hybrid nanoparticles carrying doxorubicin and edelfosine combo for synergistic anticancer effect against drug-resistant Osteosarcoma

2020 ◽  
Author(s):  
Ping Yang ◽  
Lian Zhang ◽  
Tian Wang ◽  
Qi Liu ◽  
Jing Wang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Folate Receptor ◽  
Drug Loading ◽  
Hybrid Nanoparticles ◽  
Anticancer Efficacy ◽  
Targeted Nanoparticles ◽  
Polymer Hybrid ◽  
Multiple Drugs

Abstract In this study, we have prepared a novel folate receptor-targeted doxorubicin (DOX) and edelfosine (ET)-loaded lipid polymer hybrid nanoparticle to enhance the anticancer efficacy in osteosarcoma. The dual-drug loaded nanoparticles showed a nanosized morphology and physiological stability. The targeted nanoparticles showed enhanced cellular internalization and subcellular distribution in MG63 cancer cells compared to that of non-targeted nanoparticles. Among many ratios of DOX and ET, 1:1 ratiometric combinations of drugs were observed to be highly synergistic in killing the cancer cells. MTT assay and caspase-3/7 activity assay clearly showed the superior anticancer efficacy of DE-FPLN formulations in inducing the cancer cell death. In vitro results indicate that the co-administration of two drugs in a folic acid-targeted nanoparticle could potentially induce the apoptosis and cell death. In vivo results displayed the potency of tumor cell killing and significant suppression of tumor growth without any detectable side effects. The lipid polymer hybrid nanocarriers with multiple properties of high drug loading, sequential and ratiometric drug release, improved physiological stability, prolonged blood circulation, and tumor-specific targeting are promising for the delivery of multiple drugs in the treatment of osteosarcoma.

Lipid-polymer hybrid nanoparticles: Synthesis strategies and biomedical applications

2019 ◽  
Vol 160 ◽  
pp. 130-142 ◽  
Author(s):  
Vivek Dave ◽  
Kajal Tak ◽  
Amit Sohgaura ◽  
Ashish Gupta ◽  
Veera Sadhu ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Hybrid Nanoparticles ◽  
Polymer Hybrid ◽  
Nanoparticles Synthesis

scholarly journals Preparation of HCPT-Loaded Nanoneedles with Pointed Ends for Highly Efficient Cancer Chemotherapy

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Shichao Wu ◽  
Xiangrui Yang ◽  
Yang Li ◽  
Hongjie Wu ◽  
Yu Huang ◽  
...  
Keyword(s):  
Cancer Chemotherapy ◽  
Highly Efficient

LDH-doped electrospun short fibers enable dual drug loading and multistage release for chemotherapy of drug-resistant cancer cells

2021 ◽  
Author(s):  
Yupei Ma ◽  
Du Li ◽  
Yunchao Xiao ◽  
Zhijun OuYang ◽  
Mingwu Shen ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cancer Cells ◽  
Cancer Chemotherapy ◽  
Side Effect ◽  
Drug Loading ◽  
Adverse Side Effect ◽  
Drug Resistant ◽  
Short Fibers ◽  
Dual Drug

Conventional cancer chemotherapy is facing difficulties in improving the bioavailability, overcoming the severe adverse side effect of chemotherapeutics and reversing the multidrug resistance of cancer cells. To address these challenges,...

In situ controllable synthesis of graphene oxide-based ternary magnetic molecularly imprinted polymer hybrid for efficient enrichment and detection of eight microcystins

2015 ◽  
Vol 3 (45) ◽  
pp. 23042-23052 ◽  
Author(s):  
Sheng-Dong Pan ◽  
Xiao-Hong Chen ◽  
Xiao-Ping Li ◽  
Mei-Qiang Cai ◽  
Hao-Yu Shen ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Molecularly Imprinted Polymer ◽  
Sensitive Detection ◽  
Imprinted Polymer ◽  
Controllable Synthesis ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer ◽  
Highly Efficient ◽  
Polymer Hybrid

A novel graphene oxide-based ternary magnetic molecularly imprinted polymer hybrid was synthesized for highly efficient enrichment and sensitive detection of microcystins.

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