scholarly journals miRNA-320a inhibits glioma cell invasion and migration by directly targeting aquaporin 4

2018 ◽  
Author(s):  
Wei Xiong ◽  
Jianhua Ran ◽  
Rong Jiang ◽  
Pei Guo ◽  
Xueping Shi ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Glioma Cell ◽  
Aquaporin 4 ◽  
Invasion And Migration ◽  
And Migration

scholarly journals The transcription factor USF1 promotes glioma cell invasion and migration by activating lncRNA HAS2-AS1

2020 ◽  
Vol 40 (8) ◽  
Author(s):  
Juntong Wang ◽  
Jingshun Gu ◽  
Aiwu You ◽  
Jun Li ◽  
Yuyan Zhang ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Cell Invasion ◽  
Promoter Region ◽  
Glioma Cell ◽  
Luciferase Reporter ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Invasion And Migration ◽  
Starting Point ◽  
And Migration

Abstract Objective: The role of lncRNAs in tumor has been widely concerned. The present study took HAS2-AS1 (the antisense RNA 1 of HAS2) as a starting point to explore its expression in glioma and its role in the process of migration and invasion, providing a strong theoretical basis for mining potential therapeutic targets of glioma. Methods: Clinical data of glioma were obtained from The Cancer Genome Atlas (TCGA) database and differentially expressed lncRNAs were analyzed by edgeR. The hTFtarget database was used to predict the upstream transcription factors of HAS2-AS1 and the JASPAR website was used to predict the binding sites of human upstream transcription factor 1 (USF1) and HAS2-AS1. qRT-PCR was used to detect the expressions of HAS2-AS1 and USF1 in glioma tissues and cell lines. The effects of silencing HAS2-AS1 on the migration and invasion of cancer cells were verified by wound healing and Transwell invasion assays. The chromatin immunoprecipitation (ChIP) and dual luciferase reporter assays were applied to demonstrate the binding of USF1 and HAS2-AS1 promoter region. Western blot was used to detect the expressions of epithelial–mesenchymal transition (EMT)-related proteins. Results: HAS2-AS1 was highly expressed in glioma tissues and cells, and was significantly associated with poor prognosis. Silencing HAS2-AS1 expression inhibited glioma cell migration, invasion and EMT. USF1 was highly expressed in glioma and positively correlated with HAS2-AS1. The transcription of HAS2-AS1 was activated by USF1 via binding to HAS2-AS1 promoter region, consequently potentiating the invasion and migration abilities of glioma cells. Conclusion: These results suggested that the transcription factor USF1 induced up-regulation of lncRNA HAS2-AS1 and promoted glioma cell invasion and migration.

MicroRNAs let-7b/i suppress human glioma cell invasion and migration by targeting IKBKE directly

2015 ◽  
Vol 458 (2) ◽  
pp. 307-312 ◽  
Author(s):  
Yuan Tian ◽  
Shaobo Hao ◽  
Minhua Ye ◽  
Anling Zhang ◽  
Yang Nan ◽  
...  
Keyword(s):  
Cell Invasion ◽  
Glioma Cell ◽  
Human Glioma ◽  
Invasion And Migration ◽  
Human Glioma Cell ◽  
And Migration

C6 glioma cell invasion and migration of rat brain after neural homografting

Neurosurgery ◽  
1990 ◽  
pp. 622 ◽  
Author(s):  
J J Bernstein ◽  
W J Goldberg ◽  
E R Laws ◽  
D Conger ◽  
V Morreale ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cell Invasion ◽  
Glioma Cell ◽  
C6 Glioma ◽  
Invasion And Migration ◽  
C6 Glioma Cell ◽  
And Migration

AnnexinA5 promote glioma cell invasion and migration via the PI3K/Akt/NF-κB signaling pathway

2018 ◽  
Vol 138 (3) ◽  
pp. 469-478 ◽  
Author(s):  
Chenxing Ji ◽  
Hua Guo ◽  
Pei Zhang ◽  
Wei Kuang ◽  
Yanghua Fan ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Cell Invasion ◽  
Glioma Cell ◽  
Invasion And Migration ◽  
And Migration

C6 Glioma Cell Invasion and Migration of Rat Brain after Neural Homografting: Ultrastructure

Neurosurgery ◽  
1990 ◽  
Vol 26 (4) ◽  
pp. 622-628 ◽  
Author(s):  
Jerald J. Bernstein ◽  
William J. Goldberg ◽  
Edward R. Laws ◽  
Dean Conger ◽  
Vittorio Morreale ◽  
...  
Keyword(s):  
Rat Brain ◽  
Cell Invasion ◽  
Glioma Cell ◽  
C6 Glioma ◽  
Invasion And Migration ◽  
C6 Glioma Cell ◽  
And Migration
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