Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A

Qiuyue Huang; Shanshan Qin; Xiaoning Yuan; Liang Zhang; Juanli Ji; Xuewen Liu; Wenjing Ma; Yunfei Zhang; Pengfei Liu; Zhiting Sun; Jingxuan Zhang; Ying Liu

doi:10.3892/or.2017.5667

Arctigenin inhibits triple-negative breast cancers by targeting CIP2A to reactivate protein phosphatase 2A

Oncology Reports ◽

10.3892/or.2017.5667 ◽

2017 ◽

Vol 38 (1) ◽

pp. 598-606 ◽

Cited By ~ 11

Author(s):

Qiuyue Huang ◽

Shanshan Qin ◽

Xiaoning Yuan ◽

Liang Zhang ◽

Juanli Ji ◽

...

Keyword(s):

Protein Phosphatase ◽

Triple Negative ◽

Protein Phosphatase 2A ◽

Breast Cancers ◽

Phosphatase 2A

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Induction of E-cadherin endocytosis by loss of protein phosphatase 2A expression in human breast cancers

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2006.08.037 ◽

2006 ◽

Vol 349 (1) ◽

pp. 255-260 ◽

Cited By ~ 18

Author(s):

Katsuo Suzuki ◽

Kazuhide Takahashi

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Breast Cancers ◽

Human Breast ◽

Phosphatase 2A ◽

E Cadherin

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Expression of cancerous inhibitor of protein phosphatase 2A in human triple negative breast cancer correlates with tumor survival, invasion and autophagy

Oncology Letters ◽

10.3892/ol.2016.5374 ◽

2016 ◽

Vol 12 (6) ◽

pp. 5370-5376 ◽

Cited By ~ 4

Author(s):

Shan Li ◽

Ting-Ting Feng ◽

Yang Guo ◽

Xianjun Yu ◽

Qiuyue Huang ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Protein Phosphatase ◽

Triple Negative ◽

Protein Phosphatase 2A ◽

Tumor Survival ◽

Phosphatase 2A

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Auxin transportGarbers, C., DeLong, A., Deruére, J., Bernasconi, P. and Söll, D. (1996) A mutation in protein phosphatase 2A regulatory subunit A affects auxin transport in Arabidopsis, EMBO J. 15, 2115–2124

Trends in Plant Science ◽

10.1016/s1360-1385(96)86891-0 ◽

1996 ◽

Vol 1 (7) ◽

pp. 211-211

Keyword(s):

Protein Phosphatase ◽

Auxin Transport ◽

Protein Phosphatase 2A ◽

Regulatory Subunit ◽

Subunit A ◽

Phosphatase 2A

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Faculty Opinions recommendation of Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1009236.125458 ◽

2002 ◽

Author(s):

Andreas Wodarz

Keyword(s):

Tight Junction ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Tight Junction Complex ◽

Atypical Pkc ◽

Phosphatase 2A ◽

Epithelial Tight Junction

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Faculty Opinions recommendation of Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1012648.186405 ◽

2003 ◽

Author(s):

Martin A Schwartz

Keyword(s):

Protein Kinase ◽

Protein Phosphatase ◽

Protein Kinase B ◽

Protein Phosphatase 2A ◽

Local Activation ◽

Phosphatase 2A ◽

Beta1 Integrin

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Faculty Opinions recommendation of Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1023795.367924 ◽

2006 ◽

Author(s):

Jonathan Millar

Keyword(s):

Sister Chromatid ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Sister Chromatid Cohesion ◽

Chromatid Cohesion ◽

Phosphatase 2A ◽

Meiosis I

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Faculty Opinions recommendation of Generation of active protein phosphatase 2A is coupled to holoenzyme assembly.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1087308.540326 ◽

2007 ◽

Author(s):

Ian Willis

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Active Protein ◽

Phosphatase 2A

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Faculty Opinions recommendation of REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718505432.793499740 ◽

2014 ◽

Author(s):

Rony Seger ◽

Zhong Yao

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Mtorc1 Signaling ◽

Phosphatase 2A

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Faculty Opinions recommendation of The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.7352956.10037054 ◽

2011 ◽

Author(s):

Philipp Kaldis

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Phosphatase 2A ◽

Greatwall Kinase ◽

Inhibiting Protein

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Faculty Opinions recommendation of Allosteric activators of protein phosphatase 2A display broad antitumor activity mediated by dephosphorylation of MYBL2.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.737780631.793577330 ◽

2020 ◽

Author(s):

Brion Murray

Keyword(s):

Antitumor Activity ◽

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Phosphatase 2A

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