scholarly journals Role of the cystathionine β-synthase/H2S system in liver cancer cells and the inhibitory effect of quinolone-indolone conjugate QIC2 on the system

2017 ◽  
Vol 37 (5) ◽  
pp. 3001-3009 ◽  
Author(s):  
Huina Jia ◽  
Juan Ye ◽  
Jing You ◽  
Xiaoyan Shi ◽  
Wenyi Kang ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Liver Cancer Cells

Relevance of mitochondrial dysfunction during Sorafenib-induced cell death in liver cancer cells. Role of oxidative and nitrogen reactive species

2021 ◽  
Vol 165 ◽  
pp. 54
Author(s):  
Patricia de la Cruz-Ojeda ◽  
M. Ángeles Rodríguez-Hernández ◽  
Elena Navarro-Villarán ◽  
Paloma Gallego ◽  
Pavla Staňková ◽  
...  
Keyword(s):  
Cell Death ◽  
Liver Cancer ◽  
Mitochondrial Dysfunction ◽  
Cancer Cells ◽  
Reactive Species ◽  
Liver Cancer Cells ◽  
Nitrogen Reactive Species

scholarly journals A critical role of AMPK, and Akt, mTOR and Wnt survival signals for the growth control of colon and liver cancer cells with selenium

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Lee Yun‐Kyoung ◽  
Song Yi Park ◽  
Won Sup Lee ◽  
Young‐Joon Surh ◽  
Young‐Min Kim ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Critical Role ◽  
Growth Control ◽  
Liver Cancer Cells ◽  
Survival Signals

scholarly journals The Role of Exosomes in the Crosstalk between Adipocytes and Liver Cancer Cells

Cells ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 1988
Author(s):  
Leslimar Rios-Colon ◽  
Elena Arthur ◽  
Suryakant Niture ◽  
Qi Qi ◽  
John T. Moore ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Bioactive Materials ◽  
Liver Cancer Cells ◽  
Secreted Factors ◽  
Wide Range ◽  
Pathophysiological Role ◽  
Inflammatory State ◽  
Membrane Bound

Exosomes are membrane-bound extracellular vesicles (EVs) that transport bioactive materials between cells and organs. The cargo delivered by exosomes can alter a wide range of cellular responses in recipient cells and play an important pathophysiological role in human cancers. In hepatocellular carcinoma (HCC), for example, adipocyte- and tumor-secreted factors contained in exosomes contribute to the creation of a chronic inflammatory state, which contributes to disease progression. The exosome-mediated crosstalk between adipocytes and liver cancer cells is a key aspect of a dynamic tumor microenvironment. In this review, we summarize the role of increased adiposity and the role of adipocyte-derived exosomes (AdExos) and HCC-derived exosomes (HCCExos) in the modulation of HCC progression. We also discuss recent advances regarding how malignant cells interact with the surrounding adipose tissue and employ exosomes to promote a more aggressive phenotype.

Antiproliferative Effects of Thymoquinone in MCF-7 Breast and HepG2 Liver Cancer Cells: Possible Role of Ceramide and ER Stress

2020 ◽  
pp. 1-13
Author(s):  
Mutay Aslan ◽  
Ebru Afşar ◽  
Esma Kırımlıoglu ◽  
Tuğçe Çeker ◽  
Çağatay Yılmaz
Keyword(s):  
Liver Cancer ◽  
Er Stress ◽  
Cancer Cells ◽  
Antiproliferative Effects ◽  
Liver Cancer Cells ◽  
Mcf 7

Carbidopa is an activator of aryl hydrocarbon receptor with potential for cancer therapy

2017 ◽  
Vol 474 (20) ◽  
pp. 3391-3402 ◽  
Author(s):  
Jiro Ogura ◽  
Seiji Miyauchi ◽  
Kazumi Shimono ◽  
Shengping Yang ◽  
Sathisha Gonchigar ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Liver Cancer ◽  
Aryl Hydrocarbon Receptor ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Anticancer Effect ◽  
Liver Cancer Cells ◽  
Aryl Hydrocarbon

Carbidopa is used with l-DOPA (l-3,4-dihydroxyphenylalanine) to treat Parkinson's disease (PD). PD patients exhibit lower incidence of most cancers including pancreatic cancer, but with the notable exception of melanoma. The decreased cancer incidence is not due to l-DOPA; however, the relevance of Carbidopa to this phenomenon has not been investigated. Here, we tested the hypothesis that Carbidopa, independent of l-DOPA, might elicit an anticancer effect. Carbidopa inhibited pancreatic cancer cell proliferation both in vitro and in vivo. Based on structural similarity with phenylhydrazine, an inhibitor of indoleamine-2,3-dioxygenase-1 (IDO1), we predicted that Carbidopa might also inhibit IDO1, thus providing a molecular basis for its anticancer effect. The inhibitory effect was confirmed using human recombinant IDO1. To demonstrate the inhibition in intact cells, AhR (aryl hydrocarbon receptor) activity was monitored as readout for IDO1-mediated generation of the endogenous AhR agonist kynurenine in pancreatic and liver cancer cells. Surprisingly, Carbidopa did not inhibit but instead potentiated AhR signaling, evident from increased CYP1A1 (cytochrome P450 family 1 subfamily A member 1), CYP1A2, and CYP1B1 expression. In pancreatic and liver cancer cells, Carbidopa promoted AhR nuclear localization. AhR antagonists blocked Carbidopa-dependent activation of AhR signaling. The inhibitory effect on pancreatic cancer cells in vitro and in vivo and the activation of AhR occurred at therapeutic concentrations of Carbidopa. Chromatin immunoprecipitation assay further confirmed that Carbidopa promoted AhR binding to its target gene CYP1A1 leading to its induction. We conclude that Carbidopa is an AhR agonist and suppresses pancreatic cancer. Hence, Carbidopa could potentially be re-purposed to treat pancreatic cancer and possibly other cancers as well.

scholarly journals A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells

2008 ◽  
Vol 31 (4) ◽  
pp. 722-725 ◽  
Author(s):  
Yumiko Fujiwara ◽  
Makoto Mangetsu ◽  
Ping Yang ◽  
Hisayoshi Kofujita ◽  
Koichi Suzuki ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Rat Liver ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Liver Cancer Cells ◽  
Growth Inhibitory

Inhibitory effect and mechanism of mesenchymal stem cells on liver cancer cells

Tumor Biology ◽  
2013 ◽  
Vol 35 (2) ◽  
pp. 1239-1250 ◽  
Author(s):  
Lingling Hou ◽  
Xiaoyu Wang ◽  
Yaqiong Zhou ◽  
Haibin Ma ◽  
Ziling Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Liver Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Liver Cancer Cells
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