scholarly journals A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells

2008 ◽  
Vol 31 (4) ◽  
pp. 722-725 ◽  
Author(s):  
Yumiko Fujiwara ◽  
Makoto Mangetsu ◽  
Ping Yang ◽  
Hisayoshi Kofujita ◽  
Koichi Suzuki ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cancer Cells ◽  
Rat Liver ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Liver Cancer Cells ◽  
Growth Inhibitory

scholarly journals Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Bin Han ◽  
Naohiro Fujimoto ◽  
Mizuki Kobayashi ◽  
Tetsuro Matsumoto
Keyword(s):  
Prostate Cancer ◽  
Synergistic Effect ◽  
Cancer Treatment ◽  
Cancer Cells ◽  
Prostate Cancer Cell ◽  
Inhibitory Effect ◽  
Prostate Cancer Cells ◽  
Growth Inhibitory Effect ◽  
Prostate Cancer Treatment ◽  
Growth Inhibitory

Most advanced prostate cancers progress to castration resistant prostate cancer (CRPC) after a few years of androgen deprivation therapy and the prognosis of patients with CRPC is poor. Although docetaxel and cabazitaxel can prolong the survival of patients with CRPC, inevitable progression appears following those treatments. It is urgently required to identify better or alternative therapeutic strategies. The purpose of this study was to confirm the anti-cancer activity of zoledronic acid (Zol) and determine whether inhibition of geranylgeranylation in the mevalonate pathway could be a molecular target of prostate cancer treatment. We examined the growth inhibitory effect of Zol in prostate cancer cells (LNCaP, PC3, DU145) and investigated a role of geranylgeranylation in the anticancer activity of Zol. We, then, evaluated the growth inhibitory effect of geranylgeranyltransferase inhibitor (GGTI), and analyzed the synergy of GGTI and docetaxel by combination index and isobolographic analysis. Zol inhibited the growth of all prostate cancer cell lines tested in a dose-dependent manner through inhibition of geranylgeranylation. GGTI also inhibited the prostate cancer cell growth and the growth inhibitory effect was augmented by a combination with docetaxel. Synergism between GGTI and docetaxel was observed across a broad range of concentrations. In conclusion, our results demonstrated that GGTI can inhibit the growth of prostate cancer cells and has synergistic effect with docetaxel, suggesting its potential role in prostate cancer treatment.

THE GROWTH INHIBITORY EFFECT OF p21 ADENOVIRUS ON HUMAN BLADDER CANCER CELLS

2000 ◽  
Vol 163 (3) ◽  
pp. 1033-1038 ◽  
Author(s):  
M. CRAIG HALL ◽  
YINGMING LI ◽  
REY-CHEN PONG ◽  
BRENT ELY ◽  
ARTHUR I. SAGALOWSKY ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Inhibitory Effect ◽  
Human Bladder Cancer ◽  
Growth Inhibitory Effect ◽  
Human Bladder ◽  
Growth Inhibitory ◽  
Bladder Cancer Cells ◽  
Human Bladder Cancer Cells

scholarly journals BP-M345, a New Diarylpentanoid with Promising Antimitotic Activity

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7139
Author(s):  
Pedro Novais ◽  
Patrícia M. A. Silva ◽  
Joana Moreira ◽  
Andreia Palmeira ◽  
Isabel Amorim ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Spindle Assembly Checkpoint ◽  
Human Cancer ◽  
Antitumor Agent ◽  
Inhibitory Effect ◽  
Growth Inhibitory Effect ◽  
Human Cancer Cells ◽  
Antimitotic Activity ◽  
Growth Inhibitory

Previously, we reported the in vitro growth inhibitory effect of diarylpentanoid BP-M345 on human cancer cells. Nevertheless, at that time, the cellular mechanism through which BP-M345 exerts its growth inhibitory effect remained to be explored. In the present work, we report its mechanism of action on cancer cells. The compound exhibits a potent tumor growth inhibitory activity with high selectivity index. Mechanistically, it induces perturbation of the spindles through microtubule instability. As a consequence, treated cells exhibit irreversible defects in chromosome congression during mitosis, which induce a prolonged spindle assembly checkpoint-dependent mitotic arrest, followed by massive apoptosis, as revealed by live cell imaging. Collectively, the results indicate that the diarylpentanoid BP-M345 exerts its antiproliferative activity by inhibiting mitosis through microtubule perturbation and causing cancer cell death, thereby highlighting its potential as antitumor agent.

Sign in / Sign up

Export Citation Format

Share Document