scholarly journals Expression pattern and methylation of estrogen receptor α in breast intraductal proliferative lesions

2016 ◽  
Vol 36 (4) ◽  
pp. 1868-1874 ◽  
Author(s):  
Xiaoyun Mao ◽  
Zhen Qiao ◽  
Chuifeng Fan ◽  
Ayao Guo ◽  
Xinmiao Yu ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Expression Pattern ◽  
Estrogen Receptor Α

scholarly journals The estrogen-responsive adrenomedullin and receptor-modifying protein 3 gene identified by DNA microarray analysis are directly regulated by estrogen receptor

2006 ◽  
Vol 36 (1) ◽  
pp. 81-89 ◽  
Author(s):  
H Watanabe ◽  
E Takahashi ◽  
M Kobayashi ◽  
M Goto ◽  
A Krust ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Expression Pattern ◽  
Expression Profiles ◽  
Biological Effects ◽  
Gene Expression Pattern ◽  
Estrogen Receptor Α ◽  
Null Mouse ◽  
Uterine Growth ◽  
Response Expression ◽  
Estrogen Administration

Recent studies have revealed that hundreds of genes in the uterus are activated by estrogen. Their expression profiles differ over time and doses and it is not clear whether all these genes are directly regulated by estrogen via the estrogen receptor. To select the genes that may be regulated by estrogen, we treated mice with several doses of estrogen and searched for those genes whose dose–response expression pattern mirrored the uterine growth pattern. Among those genes, we found that the dose-dependent expression of the adrenomedullin (ADM) gene correlated well with the uterotrophic effect of estrogen. ADM expression is induced early after estrogen administration and is restricted to the endometrial stroma. The spatiotemporal gene expression pattern of ADM was similar to that of receptor-modifying protein 3 (RAMP3). RAMP3 is known to modify calcitonin gene-related receptor (CRLR) so that it can then serve as an ADM receptor. Chromatin immunoprecipitation assays indicated that the estrogen receptor binds directly to the ADM promoter region and RAMP3 intron after estrogen administration. It was also shown that neither the ADM nor RAMP3 gene could be activated in estrogen receptor-α-null mouse. Although uterine ADM expression has been reported to occur in the myometrium, our observations indicate that estrogen-induced ADM is also expressed in the uterine stroma and that such variable, spatiotemporally regulated ADM expression contributes to a wider range of biological effects than previously expected.

1322: The Expression of Estrogen Receptor α and Estrogen Receptor β in the Human Fetal Prostate

2004 ◽  
Vol 171 (4S) ◽  
pp. 348-348
Author(s):  
Ellen Shapiro ◽  
Hongying Huang ◽  
Rachael R. Mash ◽  
Eliza Ng ◽  
Deborah E. McFadden ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Estrogen Receptor Α ◽  
Estrogen Receptor Β
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