Cloning and expression pattern of peroxisome proliferator-activated receptors, estrogen receptor α and retinoid X receptor α in the thicklip grey mullet Chelon labrosus

2009 ◽  
Vol 149 (1) ◽  
pp. 26-35 ◽  
Author(s):  
Damien Raingeard ◽  
Ibon Cancio ◽  
Miren P. Cajaraville
Keyword(s):  
Estrogen Receptor ◽  
Expression Pattern ◽  
Estrogen Receptor Α ◽  
Retinoid X Receptor ◽  
Cloning And Expression ◽  
Peroxisome Proliferator ◽  
Grey Mullet ◽  
Peroxisome Proliferator Activated Receptors ◽  
Chelon Labrosus

How nuclear receptors tell time

2009 ◽  
Vol 107 (6) ◽  
pp. 1965-1971 ◽  
Author(s):  
Michèle Teboul ◽  
Aline Gréchez-Cassiau ◽  
Fabienne Guillaumond ◽  
Franck Delaunay
Keyword(s):  
Nuclear Receptors ◽  
Target Genes ◽  
Clock Genes ◽  
Estrogen Receptor Α ◽  
Nuclear Hormone Receptor ◽  
Circadian Clocks ◽  
Orphan Receptor ◽  
Peroxisome Proliferator ◽  
Peripheral Clocks ◽  
Peroxisome Proliferator Activated Receptors

Most organisms adapt their behavior and physiology to the daily changes in their environment through internal (∼24 h) circadian clocks. In mammals, this time-keeping system is organized hierarchically, with a master clock located in the suprachiasmatic nuclei of the hypothalamus that is reset by light, and that, in turn, coordinates the oscillation of local clocks found in all cells. Central and peripheral clocks control, in a highly tissue-specific manner, hundreds of target genes, resulting in the circadian regulation of most physiological processes. A great deal of knowledge has accumulated during the last decade regarding the molecular basis of mammalian circadian clocks. These studies have collectively demonstrated how a set of clock genes and their protein products interact together in complex feedback transcriptional/translational loops to generate 24-h oscillations at the molecular, cellular, and organism levels. In recent years, a number of nuclear receptors (NRs) have been implicated as important regulators of the mammalian clock mechanism. REV-ERB and retinoid-related orphan receptor NRs regulate directly the core feedback loop and increase its robustness. The glucocorticoid receptor mediates the synchronizing effect of glucocorticoid hormones on peripheral clocks. Other NR family members, including the orphan NR EAR2, peroxisome proliferator activated receptors-α/γ, estrogen receptor-α, and retinoic acid receptors, are also linked to the clockwork mechanism. These findings together establish nuclear hormone receptor signaling as an integral part of the circadian timing system.

scholarly journals Expression pattern and methylation of estrogen receptor α in breast intraductal proliferative lesions

2016 ◽  
Vol 36 (4) ◽  
pp. 1868-1874 ◽  
Author(s):  
Xiaoyun Mao ◽  
Zhen Qiao ◽  
Chuifeng Fan ◽  
Ayao Guo ◽  
Xinmiao Yu ◽  
...  
Keyword(s):  
Estrogen Receptor ◽  
Expression Pattern ◽  
Estrogen Receptor Α
Sign in / Sign up

Export Citation Format

Share Document