scholarly journals Curcumin induces autophagy, inhibits proliferation and invasion by downregulating AKT/mTOR signaling pathway in human melanoma cells

2015 ◽  
Vol 35 (2) ◽  
pp. 1065-1074 ◽  
Author(s):  
GUANGMING ZHAO ◽  
XIAODONG HAN ◽  
SIWEN ZHENG ◽  
ZHEN LI ◽  
YANG SHA ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Human Melanoma Cells ◽  
Proliferation And Invasion

scholarly journals LncRNA GASAL1 Interacts with SRSF1 to Regulate Trophoblast Cell Proliferation, Invasion, and Apoptosis Via the mTOR Signaling Pathway

2020 ◽  
Vol 29 ◽  
pp. 096368972096518
Author(s):  
Jia Liu ◽  
Qing Zhang ◽  
Nan Ma
Keyword(s):  
Cell Proliferation ◽  
Signaling Pathway ◽  
Mammalian Target Of Rapamycin ◽  
Potential Interaction ◽  
Trophoblast Cell ◽  
Mtor Signaling ◽  
Mtor Signaling Pathway ◽  
Promote Cell Proliferation ◽  
Proliferation And Invasion ◽  
Jar Cells

Long noncoding RNAs (lncRNAs) are crucial regulatory molecules involved in diverse biological processes and human diseases, including preeclampsia (PE). The lncRNA growth arrest associated lncRNA 1 (GASAL1) has been implicated in multiple malignant solid tumors and other diseases, while it is poorly known as the potential molecular mechanism of GASAL1 in PE. In this study, GASAL1 was significantly downregulated in the placentas’ of tissues from primipara with PE and trophoblast cell lines. Then, the upregulation of GASAL1 dramatically decreased proliferation and invasion and enhanced apoptosis in HTR-8/SVneo and JAR cells. Bioinformatics tool predicated that there is a potential interaction between GASAL1 and serine/arginine splicing factor 1 (SRSF1). RNA pull-down assays showed that GASAL1 directly binds with SRSF1 that could promote cell proliferation and invasion and suppress cell apoptosis. Further research showed that promoting effects of trophoblasts proliferation and invasion caused by co-transfecting GASAL1 and SRSF1 into HTR-8/SVneo and JAR cells were impaired by SRSF1 knockdown. Moreover, inhibition of the mammalian target of rapamycin (mTOR) activity by rapamycin influenced the effects of GASAL1 on cell proliferation, invasion, and apoptosis. Taken together, these findings suggest that lncRNA GASAL1 interacts with SRSF1 to regulate the proliferative, invasive, and apoptotic abilities of trophoblast cells via the mTOR signaling pathway.

scholarly journals Inhibition of proliferation and invasion in 2D and 3D models by 2-methoxyestradiol in human melanoma cells

2017 ◽  
Vol 119 ◽  
pp. 242-250 ◽  
Author(s):  
R.R. Massaro ◽  
F. Faião-Flores ◽  
V.W. Rebecca ◽  
S. Sandri ◽  
D.K. Alves-Fernandes ◽  
...  
Keyword(s):  
3D Models ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Inhibition Of Proliferation ◽  
Human Melanoma Cells ◽  
2D And 3D ◽  
Proliferation And Invasion

scholarly journals Circulating microRNA-194 regulates human melanoma cells via PI3K/AKT/FoxO3a and p53/p21 signaling pathway

2017 ◽  
Vol 37 (5) ◽  
pp. 2702-2710 ◽  
Author(s):  
Ming Bai ◽  
Mingzi Zhang ◽  
Fei Long ◽  
Nanze Yu ◽  
Ang Zeng ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Circulating Microrna ◽  
Human Melanoma Cells
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