scholarly journals Regulator of G protein signaling 4 inhibits human melanoma cells proliferation and invasion through the PI3K/AKT signaling pathway

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 78530-78544 ◽  
Author(s):  
Xiaotong Xue ◽  
Lihua Wang ◽  
Xianguang Meng ◽  
Jing Jiao ◽  
Ningning Dang
Keyword(s):  
Signaling Pathway ◽  
G Protein ◽  
Melanoma Cells ◽  
Akt Signaling ◽  
Human Melanoma ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Akt Signaling Pathway ◽  
Human Melanoma Cells ◽  
Proliferation And Invasion

scholarly journals MicroRNA-331 Inhibits Proliferation and Invasion of Melanoma Cells by Targeting Astrocyte-Elevated Gene-1

2018 ◽  
Vol 26 (9) ◽  
pp. 1429-1437 ◽  
Author(s):  
Li Chen ◽  
Guozhang Ma ◽  
Xiaohui Cao ◽  
Xiaoxia An ◽  
Xiguang Liu
Keyword(s):  
Signaling Pathway ◽  
Quantitative Polymerase Chain Reaction ◽  
Expression Patterns ◽  
Polymerase Chain Reaction Analysis ◽  
Melanoma Cells ◽  
Akt Signaling ◽  
Chemotherapeutic Agents ◽  
Luciferase Reporter ◽  
Akt Signaling Pathway ◽  
Proliferation And Invasion

Melanoma is characterized by aggressive invasion, early metastasis, and resistance to existing chemotherapeutic agents. Accumulated studies have reported that microRNA (miRNA) is a potentially robust molecular tool for developing future therapeutic technologies. Therefore, examining the expression patterns, biological roles, and associated mechanisms of cancer-related miRNAs in melanoma is essential for developing novel therapeutic targets for patients with this disease. In this study, miRNA-331 (miR-331) was underexpressed in melanoma tissues and cell lines. Functional assays revealed that the enforced expression of miR-331 inhibited cell proliferation and invasion. In addition, astrocyte-elevated gene-1 (AEG-1) was identified as a novel target of miR-331 through bioinformatics analysis, reverse transcription quantitative polymerase chain reaction analysis, Western blot analysis, dual-luciferase reporter assay, and Spearman’s correlation analysis. Furthermore, reintroduction of AEG-1 partially abrogated the inhibitory effects of miR-331 overexpression on the proliferation and invasion of melanoma cells. Moreover, miR-331 suppressed the activation of the PTEN/AKT signaling pathway in melanoma by inhibiting AEG-1. In short, miR-331 may play tumor-suppressive roles in melanoma by directly targeting AEG-1 and regulating the PTEN/AKT signaling pathway, suggesting that miR-331 could be investigated as a therapeutic strategy for patients with this malignancy.

scholarly journals Lyn Kinase Promotes the Proliferation of Malignant Melanoma Cells through Inhibition of Apoptosis and Autophagy via the PI3K/Akt Signaling Pathway

2019 ◽  
Vol 10 (5) ◽  
pp. 1197-1208 ◽  
Author(s):  
Qianqian Zhang ◽  
Xianguang Meng ◽  
Guojing Qin ◽  
Xiaotong Xue ◽  
Ningning Dang
Keyword(s):  
Malignant Melanoma ◽  
Signaling Pathway ◽  
Melanoma Cells ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Lyn Kinase

scholarly journals Knockdown of JARID2 inhibits the proliferation and invasion of ovarian cancer through the PI3K/Akt signaling pathway

2017 ◽  
Vol 16 (3) ◽  
pp. 3600-3605 ◽  
Author(s):  
Jian Cao ◽  
Huiling Li ◽  
Guangquan Liu ◽  
Suping Han ◽  
Pengfei Xu
Keyword(s):  
Ovarian Cancer ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Proliferation And Invasion

scholarly journals Heterotrimeric G-Protein Signalers and RGSs in Aspergillus fumigatus

Pathogens ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 902
Author(s):  
Hee-Soo Park ◽  
Min-Ju Kim ◽  
Jae-Hyuk Yu ◽  
Kwang-Soo Shin
Keyword(s):  
Aspergillus Fumigatus ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
G Protein ◽  
G Proteins ◽  
Pathogenic Fungus ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Heterotrimeric G Protein ◽  
External Signals

The heterotrimeric G-protein (G-protein) signaling pathway is one of the most important signaling pathways that transmit external signals into the inside of the cell, triggering appropriate biological responses. The external signals are sensed by various G-protein-coupled receptors (GPCRs) and transmitted into G-proteins consisting of the α, β, and γ subunits. Regulators of G-protein signaling (RGSs) are the key controllers of G-protein signaling pathways. GPCRs, G-proteins, and RGSs are the primary upstream components of the G-protein signaling pathway, and they are highly conserved in most filamentous fungi, playing diverse roles in biological processes. Recent studies characterized the G-protein signaling components in the opportunistic pathogenic fungus Aspergillus fumigatus. In this review, we have summarized the characteristics and functions of GPCRs, G-proteins, and RGSs, and their regulatory roles in governing fungal growth, asexual development, germination, stress tolerance, and virulence in A. fumigatus.

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