scholarly journals miR-203 inhibits arecoline-induced epithelial-mesenchymal transition by regulating secreted frizzled-related protein 4 and transmembrane-4 L six family member 1 in oral submucous fibrosis

2015 ◽  
Vol 33 (6) ◽  
pp. 2753-2760 ◽  
Author(s):  
LIAN ZHENG ◽  
XINCHUN JIAN ◽  
FENG GUO ◽  
NING LI ◽  
CANHUA JIANG ◽  
...  
Keyword(s):  
Family Member ◽  
Epithelial Mesenchymal Transition ◽  
Oral Submucous Fibrosis ◽  
Related Protein ◽  
Mesenchymal Transition ◽  
Submucous Fibrosis

scholarly journals Assessment of epithelial–mesenchymal transition signatures in oral submucous fibrosis

2019 ◽  
Vol 23 (2) ◽  
pp. 308
Author(s):  
RShesha Prasad ◽  
Anuradha Pai ◽  
K Shyamala ◽  
Abhishek Bhadranna ◽  
Sadhana Shenoy ◽  
...  
Keyword(s):  
Epithelial Mesenchymal Transition ◽  
Oral Submucous Fibrosis ◽  
Mesenchymal Transition ◽  
Submucous Fibrosis

scholarly journals Molecular Pathogenesis of Oral Submucous Fibrosis: A Critical Appraisal

2019 ◽  
Vol 12 (04) ◽  
pp. 2027-2036 ◽  
Author(s):  
Arpita Rai ◽  
Musarrat Siddiqui ◽  
Shama Parveen ◽  
Saba Parveen ◽  
Abdur Rasheed ◽  
...  
Keyword(s):  
Critical Appraisal ◽  
Epithelial Mesenchymal Transition ◽  
Oral Submucous Fibrosis ◽  
Molecular Pathogenesis ◽  
Areca Nut ◽  
Mesenchymal Transition ◽  
Potentially Malignant ◽  
Submucous Fibrosis ◽  
Malignant Condition

Oral submucous fibrosis (OSMF) is a chronic, potentially malignant condition of the oral mucosa and the habitual chewing of areca nut is believed to be the most potent etiological factor. The role of reactive oxygen species (ROS), epithelial-mesenchymal transition (EMT) and various cytokines and growth factors has been established in recent studies. The components of areca nut particularly, arecoline, flavonoids and copper have been found to affect fibroblasts, endothelial and epithelial cells through various biological pathways which are either down-regulated or up-regulated during different stages of the disease. However, the underlying molecular pathogenesis of OSMF is still partially understood.

scholarly journals Investigations on the Role of the MicroRNA-338-5p/Wnt Family Member 2B (WNT2B) Axis in Regulating the Pathogenesis of Nasopharyngeal Carcinoma (NPC)

2021 ◽  
Vol 11 ◽  
Author(s):  
Suzhen Wang ◽  
Tianning Yang ◽  
Zhengxiang He
Keyword(s):  
Family Member ◽  
Colony Formation ◽  
Epithelial Mesenchymal Transition ◽  
Colony Formation Assay ◽  
Transwell Assay ◽  
Mesenchymal Transition ◽  
Downstream Target

BackgroundThe involvement of microRNA-338-5p in modulating NPC pathogenesis is still largely unknown, and this study aimed to investigate this issue.MethodsThe expressions of cancer associated genes were determined by Real-Time qPCR and Western Blot, and cell apoptosis was determined by flow cytometer (FCM). CCK-8 assay and colony formation assay were respectively used to determine cell proliferation and colony formation abilities. Transwell assay was used to evaluate cell migration. The expression levels of Ki67 protein in mice tissues were measured by Immunohistochemistry (IHC) assay.ResultsThe present study found that microRNA-338-5p suppressed NPC progression by degrading its downstream target, Wnt family member 2B (WNT2B). Specifically, microRNA-338-5p tended to be low-expressed in NPC tissues and cell lines, compared to the non-tumor nasopharyngeal mucosa tissues and normal nasopharyngeal cell line (NP69). Upregulation of microRNA-338-5p inhibited proliferation, mobility, and epithelial-mesenchymal transition (EMT) in NPC cells in vitro, while silencing of microRNA-338-5p had opposite effects. Consistently, microRNA-338-5p suppressed tumorigenesis of NPC cells in vivo. In addition, microRNA-338-5p targeted WNT2B for degradation and inhibition, and the inhibiting effects of microRNA-338-5p overexpression on NPC development were reversed by upregulating WNT2B.ConclusionsTaken together, we concluded that microRNA-338-5p targeted WNT2B to hinder NPC development.

scholarly journals Parathyroid Hormone–Related Protein Promotes Epithelial–Mesenchymal Transition

2009 ◽  
Vol 21 (2) ◽  
pp. 237-248 ◽  
Author(s):  
Juan Antonio Ardura ◽  
Sandra Rayego-Mateos ◽  
David Rámila ◽  
Marta Ruiz-Ortega ◽  
Pedro Esbrit
Keyword(s):  
Parathyroid Hormone ◽  
Epithelial Mesenchymal Transition ◽  
Related Protein ◽  
Mesenchymal Transition ◽  
Parathyroid Hormone Related Protein
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