scholarly journals Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis

2015 ◽  
Vol 33 (4) ◽  
pp. 1667-1674 ◽  
Author(s):  
YUKINAO ISHIBASHI ◽  
HIROAKI MIYOSHI ◽  
KOJI HIRAOKA ◽  
FUMIKO ARAKAWA ◽  
TOSHIAKI HARAGUCHI ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Protein Expression ◽  
Anaplastic Lymphoma Kinase ◽  
Soft Tissue Tumors ◽  
Anaplastic Lymphoma ◽  
Genetic Abnormalities

Expression of anaplastic lymphoma kinase in soft tissue tumors: An immunohistochemical and molecular study of 249 cases

2004 ◽  
Vol 35 (6) ◽  
pp. 711-721 ◽  
Author(s):  
Xiao-Qiu Li ◽  
Masanori Hisaoka ◽  
Da-Ren Shi ◽  
Xiong-Zeng Zhu ◽  
Hiroshi Hashimoto
Keyword(s):  
Soft Tissue ◽  
Anaplastic Lymphoma Kinase ◽  
Molecular Study ◽  
Soft Tissue Tumors ◽  
Anaplastic Lymphoma

scholarly journals Case Reports in Oncological Medicine Myoepithelioma: A New Rearrangement Involving the LPP Locus in a Case of Multiple Bone and Soft Tissue Lesions

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Géraldine Pairet ◽  
Gaëlle Tilman ◽  
Rafaël Sciot ◽  
Thomas Schubert ◽  
Vasiliki Perlepe ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Protein Expression ◽  
Case Reports ◽  
S100 Protein ◽  
Soft Tissue Tumors ◽  
Molecular Karyotyping ◽  
Genomic Alteration ◽  
Navicular Bone ◽  
Mesenchymal Tumors ◽  
Epithelial Markers

We report a case of multiple myoepithelioma with synchronous bone and soft tissue tumors, associated with a new genomic alteration of the LPP locus. The lesions occurred in the foot by presenting one lump in the plantar soft tissue, and three lesions were detected in the calcaneus and in the navicular bone. All tumors showed the double immunophenotype of epithelial markers and S100 protein expression. No rearrangement of the EWSR1 and FUS loci was detected as reported in myoepitheliomas. However, molecular karyotyping detected an unbalanced rearrangement of the LPP locus, not involving the HMGA2 locus, which is the most frequent translocation partner observed in benign mesenchymal tumors such as lipomas (of soft tissue as well as parosteal) and pulmonary chondroid hamartoma.

Anaplastic Lymphoma Kinase Aberrations in Rhabdomyosarcoma: Clinical and Prognostic Implications

2012 ◽  
Vol 30 (3) ◽  
pp. 308-315 ◽  
Author(s):  
J. Carlijn van Gaal ◽  
Uta E. Flucke ◽  
Melissa H.S. Roeffen ◽  
Eveline S.J.M. de Bont ◽  
Stefan Sleijfer ◽  
...  
Keyword(s):  
Protein Expression ◽  
Metastatic Disease ◽  
Anaplastic Lymphoma Kinase ◽  
Copy Number ◽  
Gene Copy ◽  
Disease Specific Survival ◽  
Anaplastic Lymphoma ◽  
Prognostic Implications ◽  
Alk Protein ◽  
Disease Specific

Purpose The aim of this study is to investigate anaplastic lymphoma kinase (ALK) protein expression and underlying genetic aberrations in rhabdomyosarcoma (RMS), with special attention to clinical and prognostic implications. Patients and Methods A total of 189 paraffin-embedded RMS tumor specimens from 145 patients were collected on tissue microarray. ALK protein expression was evaluated by immunohistochemistry. ALK gene (2p23) copy number and translocations were determined by in situ hybridization. cDNA sequencing of the receptor tyrosine kinase domain of the ALK gene was assessed in 43 samples. Results Strong cytoplasmic ALK protein expression was more frequently observed in alveolar RMS (ARMS) than in embryonal RMS (ERMS) (81% v 32%, respectively; P < .001). ALK gene copy number gain was detected in the vast majority of ARMS (88%), compared with 52% of ERMS (P < .001). ALK copy number correlated with protein expression in primary tumors (n = 107). We identified one point mutation (2%) and seven tumors harboring whole exon deletions (16%). In ERMS, specific ALK gain in the primary tumor correlated with metastatic disease (100% in metastatic disease v 29% in nonmetastatic disease; P = .004) and poor disease-specific survival (5-year disease-specific survival: 62% v 82% for nonspecific or no gain; P = .046). Conclusion Because ALK aberrations on genomic and protein levels are frequently found in RMSs, in particular ARMS, and are associated with disease progression and outcome in ERMS, ALK may play a role in tumor biology and may provide a potential therapeutic target for these tumors. Future research should aim at the oncogenic role of ALK and the potential effect of ALK inhibitors in RMS.

scholarly journals Anaplastic lymphoma kinase protein expression predicts micrometastases and prognosis for patients with hepatocellular carcinoma

2015 ◽  
Vol 11 (1) ◽  
pp. 213-223 ◽  
Author(s):  
JIANHUA LIU ◽  
HAOSHENG JIN ◽  
HONGXIA TIAN ◽  
GUODA LIAN ◽  
SHAOJIE CHEN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Expression ◽  
Anaplastic Lymphoma Kinase ◽  
Anaplastic Lymphoma

scholarly journals Inflammatory Myofibroblastic Tumor in the Inguinal canal: A Rare Case Report

2022 ◽  
Author(s):  
Arpankumar Patel ◽  
Rutikbhai Desai ◽  
Hilloni Shah ◽  
Laseena Vaisyambath ◽  
Manozna Karri ◽  
...  
Keyword(s):  
Risk Factors ◽  
Soft Tissue ◽  
Inflammatory Myofibroblastic Tumor ◽  
Case Reports ◽  
Symptomatic Treatment ◽  
Soft Tissue Tumors ◽  
Anaplastic Lymphoma ◽  
Rare Case Report ◽  
Inflammatory Pseudotumors ◽  
Specific Symptoms

Abstract Background Inflammatory myofibroblastic tumors, previously known as inflammatory pseudotumors, are rare soft tissue carcinomas with variable presentation and location. Due to non-specific symptoms and location, the diagnosis of this condition is often clinically challenging. Only a handful of case reports have been published in the literature describing this tumor, and there is still a lack of consensus on pathogenesis, risk factors, and treatment strategy. Most tumors have shown mutation in the anaplastic lymphoma receptor tyrosine kinase (ALK) gene. In this article, we describe a case of ALK-negative malignant inflammatory myofibroblastic tumor. Case A 46 years old male with no risk factors presented with a mass in the inguinal region. The ultrasound was suggestive of a mixed echoic mass suggestive of inguinal hernia, which led to surgical repair with resection of the tumor segment. Subsequently, histopathology and immunohistochemistry confirmed that the mass was an inflammatory myofibroblastic tumor which then recurred in a few years and failed to respond to multiple chemotherapy regimens, and over time, it progressively metastasized to the anterior abdominal wall and lungs. The patient is currently receiving palliative chemotherapy and symptomatic treatment. Conclusion This rare soft tissue tumor has not received much attention, and clinicians often miss the diagnosis. We stress that further study should be carried out on these soft tissue tumors, and adequate diagnostic and therapy recommendations should be developed.

Detection of specific genetic abnormalities by fluorescence in situ hybridization in soft tissue tumors

2011 ◽  
Vol 62 (1) ◽  
pp. 16-27 ◽  
Author(s):  
Yasuhiro Miura ◽  
Yoshiko Keira ◽  
Jiro Ogino ◽  
Katsuya Nakanishi ◽  
Hiroko Noguchi ◽  
...  
Keyword(s):  
In Situ Hybridization ◽  
Soft Tissue ◽  
Fluorescence In Situ Hybridization ◽  
Soft Tissue Tumors ◽  
Genetic Abnormalities

Localization of Gallium-67 in Peritoneal Cells by Electron Microscopic Autoradiography

1973 ◽  
Vol 31 ◽  
pp. 404-405
Author(s):  
D. C. Swartzendruber ◽  
Norma L. Idoyaga-Vargas
Keyword(s):  
Clinical Trials ◽  
Soft Tissue ◽  
Tumor Tissue ◽  
Soft Tissue Tumors ◽  
Clinical Usefulness ◽  
Electron Microscopic ◽  
Normal Cells ◽  
Electron Microscopic Autoradiography ◽  
Peritoneal Cells ◽  
Gallium 67

The radionuclide gallium-67 (67Ga) localizes preferentially but not specifically in many human and experimental soft-tissue tumors. Because of this localization, 67Ga is used in clinical trials to detect humar. cancers by external scintiscanning methods. However, the fact that 67Ga does not localize specifically in tumors requires for its eventual clinical usefulness a fuller understanding of the mechanisms that control its deposition in both malignant and normal cells. We have previously reported that 67Ga localizes in lysosomal-like bodies, notably, although not exclusively, in macrophages of the spocytaneous AKR thymoma. Further studies on the uptake of 67Ga by macrophages are needed to determine whether there are factors related to malignancy that might alter the localization of 67Ga in these cells and thus provide clues to discovering the mechanism of 67Ga localization in tumor tissue.

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