scholarly journals Anaplastic lymphoma kinase protein expression predicts micrometastases and prognosis for patients with hepatocellular carcinoma

2015 ◽  
Vol 11 (1) ◽  
pp. 213-223 ◽  
Author(s):  
JIANHUA LIU ◽  
HAOSHENG JIN ◽  
HONGXIA TIAN ◽  
GUODA LIAN ◽  
SHAOJIE CHEN ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Protein Expression ◽  
Anaplastic Lymphoma Kinase ◽  
Anaplastic Lymphoma

Anaplastic Lymphoma Kinase Aberrations in Rhabdomyosarcoma: Clinical and Prognostic Implications

2012 ◽  
Vol 30 (3) ◽  
pp. 308-315 ◽  
Author(s):  
J. Carlijn van Gaal ◽  
Uta E. Flucke ◽  
Melissa H.S. Roeffen ◽  
Eveline S.J.M. de Bont ◽  
Stefan Sleijfer ◽  
...  
Keyword(s):  
Protein Expression ◽  
Metastatic Disease ◽  
Anaplastic Lymphoma Kinase ◽  
Copy Number ◽  
Gene Copy ◽  
Disease Specific Survival ◽  
Anaplastic Lymphoma ◽  
Prognostic Implications ◽  
Alk Protein ◽  
Disease Specific

Purpose The aim of this study is to investigate anaplastic lymphoma kinase (ALK) protein expression and underlying genetic aberrations in rhabdomyosarcoma (RMS), with special attention to clinical and prognostic implications. Patients and Methods A total of 189 paraffin-embedded RMS tumor specimens from 145 patients were collected on tissue microarray. ALK protein expression was evaluated by immunohistochemistry. ALK gene (2p23) copy number and translocations were determined by in situ hybridization. cDNA sequencing of the receptor tyrosine kinase domain of the ALK gene was assessed in 43 samples. Results Strong cytoplasmic ALK protein expression was more frequently observed in alveolar RMS (ARMS) than in embryonal RMS (ERMS) (81% v 32%, respectively; P < .001). ALK gene copy number gain was detected in the vast majority of ARMS (88%), compared with 52% of ERMS (P < .001). ALK copy number correlated with protein expression in primary tumors (n = 107). We identified one point mutation (2%) and seven tumors harboring whole exon deletions (16%). In ERMS, specific ALK gain in the primary tumor correlated with metastatic disease (100% in metastatic disease v 29% in nonmetastatic disease; P = .004) and poor disease-specific survival (5-year disease-specific survival: 62% v 82% for nonspecific or no gain; P = .046). Conclusion Because ALK aberrations on genomic and protein levels are frequently found in RMSs, in particular ARMS, and are associated with disease progression and outcome in ERMS, ALK may play a role in tumor biology and may provide a potential therapeutic target for these tumors. Future research should aim at the oncogenic role of ALK and the potential effect of ALK inhibitors in RMS.

scholarly journals Anaplastic lymphoma kinase protein expression, genetic abnormalities, and phosphorylation in soft tissue tumors: Phosphorylation is associated with recurrent metastasis

2015 ◽  
Vol 33 (4) ◽  
pp. 1667-1674 ◽  
Author(s):  
YUKINAO ISHIBASHI ◽  
HIROAKI MIYOSHI ◽  
KOJI HIRAOKA ◽  
FUMIKO ARAKAWA ◽  
TOSHIAKI HARAGUCHI ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Protein Expression ◽  
Anaplastic Lymphoma Kinase ◽  
Soft Tissue Tumors ◽  
Anaplastic Lymphoma ◽  
Genetic Abnormalities

Anaplastic Lymphoma Kinase in Human Cancer

2012 ◽  
Vol 17 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Christina Schonherr ◽  
Bengt Hallberg ◽  
Ruth Palmer
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Human Cancer ◽  
Anaplastic Lymphoma
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