scholarly journals microRNA-206 attenuates tumor proliferation and migration involving the downregulation of NOTCH3 in colorectal cancer

2015 ◽  
Vol 33 (3) ◽  
pp. 1402-1410 ◽  
Author(s):  
XIAO-WEI WANG ◽  
XUE-QIN XI ◽  
JIAN WU ◽  
YI-YUAN WAN ◽  
HONG-XIA HUI ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Tumor Proliferation ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals Research status of relationship between schistosomiasis and colorectal cancer

2020 ◽  
Vol 3 (1) ◽  
pp. 11
Author(s):  
Xingguang Yang ◽  
Jiwu Yang ◽  
Xiangnong Cun ◽  
Pengju Zhao ◽  
Wei Cheng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Clinical Practice ◽  
Cancer Cells ◽  
Intestinal Tract ◽  
Mucosal Inflammation ◽  
Tumor Proliferation ◽  
Serious Infection ◽  
And Migration ◽  
The Relationship ◽  
Proliferation And Migration

<p>In clinical practice, intestinal mucosal inflammation caused by schistosomiasis has great risks to lead to tumor proliferation and migration of cancer cells. Without timely and effective intervention, chronic schistosomiasis infection induced will further deteriorate into colorectal cancer. On the whole, schistosomiasis once caused serious infection to China. Patients suffering from colorectal cancer who have been infected with schistosomiasis can be diagnosed as schistosomiasis-related colorectal cancer if their preoperative intestinal tract has infection manifestations and postoperative pathology indicates that eggs are deposited near the focus. This paper explores the relationship between schistosomiasis and colorectal cancer by combining relevant data and literature at home and abroad.</p>

scholarly journals USP13 Regulates the Breast Tumor Proliferation and Migration through the Stabilization of PDCD4 Protein

2021 ◽  
Author(s):  
Jun Tian ◽  
Bei Li ◽  
Jing Qiao ◽  
Xinfeng Pang ◽  
Xiaojing Yue
Keyword(s):  
Breast Cancer ◽  
Cell Proliferation ◽  
Cell Lines ◽  
Breast Tumor ◽  
Soft Agar ◽  
Tumor Proliferation ◽  
Soft Agar Assay ◽  
And Migration ◽  
Cancer Tissues ◽  
Proliferation And Migration

Abstract Background: Programmed cell death protein 4 (PDCD4), which serves as a tumor suppressor protein, plays a important role in cell proliferation,apoptosis, cell migration and DNA-damage response.However, the exact mechanism for the deubiquitination of PDCD4 remain unclear.Methods: Western blotting was used to detect the expression of PDCD4 in the breast cancer tissues and BC cell lines. We identified the potential PDCD4 associated deubiquitinase by RNAi screening. GST-Pull down and domain-mapping analysis were used to reveal that USP13 and PDCD4 directly interact with each other.Flow cytometry was used to detect the changes of G1 to S phase. Soft agar assay was used to measure the changes of the cell proliferation efficiency.Results: The expression of PDCD4 was decreased in the breast cancer tissues and BC cell lines. USP13 as a potential PDCD4 associated deubiquitinase. USP13 physically interacted with PDCD4 and greatly increased the steady state of PDCD4 through the ubiquitin-proteasome pathway.Importantly, silencing of the USP13 facilitated cell cycle from G1 to Sphase, promoted breast tumor cells proliferation and migration through downregulation of PDCD4. Conclusions: Together, these results suggest that USP13 plays an important role in the breast tumor proliferation and migration through modulating PDCD4 stability.

AMP‐kinase inhibitor dorsomorphin reduces the proliferation and migration behavior of colorectal cancer cells by targeting the AKT/mTOR pathway

IUBMB Life ◽  
2019 ◽  
Vol 71 (12) ◽  
pp. 1929-1936
Author(s):  
Sadaf Ghanaatgar‐Kasbi ◽  
Forouzan Amerizadeh ◽  
Farzad Rahmani ◽  
Seyed Mahdi Hassanian ◽  
Majid Khazaei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Mtor Pathway ◽  
Migration Behavior ◽  
Amp Kinase ◽  
Colorectal Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals LINC00667/miR-449b-5p/YY1 axis promotes cell proliferation and migration in colorectal cancer

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Juan Yu ◽  
Furang Wang ◽  
Jun Zhang ◽  
Jing Li ◽  
Xiaoguang Chen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration
Sign in / Sign up

Export Citation Format

Share Document