AMP‐kinase inhibitor dorsomorphin reduces the proliferation and migration behavior of colorectal cancer cells by targeting the AKT/mTOR pathway

IUBMB Life ◽  
2019 ◽  
Vol 71 (12) ◽  
pp. 1929-1936
Author(s):  
Sadaf Ghanaatgar‐Kasbi ◽  
Forouzan Amerizadeh ◽  
Farzad Rahmani ◽  
Seyed Mahdi Hassanian ◽  
Majid Khazaei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Kinase Inhibitor ◽  
Mtor Pathway ◽  
Migration Behavior ◽  
Amp Kinase ◽  
Colorectal Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

Berberine inhibits proliferation and migration of colorectal cancer cells by downregulation of GRP78

2020 ◽  
Vol 31 (2) ◽  
pp. 141-149 ◽  
Author(s):  
Chenxue Gong ◽  
Xiao Hu ◽  
Yingling Xu ◽  
Jinhuan Yang ◽  
Lei Zong ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

FH535 inhibits proliferation and migration of colorectal cancer cells by regulating CyclinA2 and Claudin1 gene expression

Gene ◽  
2019 ◽  
Vol 690 ◽  
pp. 48-56 ◽  
Author(s):  
Xuezi Tu ◽  
Dan Hong ◽  
Yiyan Jiang ◽  
Zhefeng Lou ◽  
Keke Wang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colorectal Cancer ◽  
Cancer Cells ◽  
Colorectal Cancer Cells ◽  
And Migration ◽  
Proliferation And Migration

scholarly journals The Influence of Curcumin on the Downregulation of MYC, Insulin and IGF-1 Receptors: A possible Mechanism Underlying the Anti-Growth and Anti-Migration in Chemoresistant Colorectal Cancer Cells

Medicina ◽  
2019 ◽  
Vol 55 (4) ◽  
pp. 90 ◽  
Author(s):  
Seyed Ahmad Hosseini ◽  
Hamid Zand ◽  
Makan Cheraghpour
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Cancer Cells ◽  
Insulin Like Growth Factor ◽  
Anticancer Properties ◽  
Colorectal Cancer Cells ◽  
Cellular Homolog ◽  
And Migration ◽  
Migration Capacity ◽  
Proliferation And Migration

Background and objectives: Mounting evidence shows that curcumin, a bioactive substance originating from turmeric root, has anticancer properties. Additionally, curcumin prevents the migration and metastasis of tumor cells. However, the molecular mechanism involved in the anti-metastatic action of curcumin is not clear. Most studies have suggested that migration inhibition is related to curcumin’s anti-inflammatory properties. Curcumin possesses a regulatory effect on insulin and insulin-like growth factor-1 (IGF-1) receptors and signaling. Insulin signaling is one of the important pathways involved in tumor initiation and progression; therefore, we proposed that the anti-metastatic effect of curcumin may mediate the downregulation of insulin and insulin-like growth factor-1 receptors. Materials and Methods: Viable resistant cells resulting from treating SW480 cells with 5-fluorouracil (5-FU) were subjected to curcumin treatment to analyze the proliferation and migration capacity in comparison to the untreated counterparts. To test the proliferation and migration potential, MTT, colony formation, and wound healing assays were performed. Real-time polymerase chain reaction (RT-PCR) was performed to measure the mRNA expression of insulin-like growth factor-1R (IGF-1R), insulin receptor (IR), and avian myelocytomatosis virus oncogene cellular homolog (MYC). Results: Our findings showed that curcumin significantly decreased insulin and IGF-1 receptors in addition to MYC expression. Additionally, the downregulation of the insulin and insulin-like growth factor-1 receptors was correlated to a greater decrease in the proliferation and migration of chemoresistant colorectal cancer cells. Conclusions: These results suggest the possible therapeutic effectiveness of curcumin in adjuvant therapy in metastatic colorectal cancer.

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