scholarly journals Analysis of the amount of tissue sample necessary for mitotic count and Ki-67 index in gastrointestinal stromal tumor sampling

2014 ◽  
Vol 33 (1) ◽  
pp. 215-222 ◽  
Author(s):  
HIDEKI KOBARA ◽  
HIROHITO MORI ◽  
KAZI RAFIQ ◽  
SHINTARO FUJIHARA ◽  
NORIKO NISHIYAMA ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Tissue Sample ◽  
Mitotic Count ◽  
Stromal Tumor ◽  
Ki 67 ◽  
Tumor Sampling

scholarly journals Prognostic Significance of Ki-67 Expression in Patients Undergoing Surgical Resection for Gastrointestinal Stromal Tumor

2014 ◽  
Vol 64 (2) ◽  
pp. 87 ◽  
Author(s):  
Seong Yeon Jeong ◽  
Won Wo Park ◽  
You Sun Kim ◽  
Young Il Park ◽  
Seung Hyup Kim ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Surgical Resection ◽  
Prognostic Significance ◽  
Stromal Tumor ◽  
Ki 67

scholarly journals Image analysis is an excellent tool for quantifying Ki-67 to predict the prognosis of gastrointestinal stromal tumor patients

2017 ◽  
Vol 68 (1) ◽  
pp. 7-11 ◽  
Author(s):  
Shintaro Sugita ◽  
Hiroshi Hirano ◽  
Yutaka Hatanaka ◽  
Hiromi Fujita ◽  
Terufumi Kubo ◽  
...  
Keyword(s):  
Image Analysis ◽  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Tumor Patients ◽  
Ki 67 ◽  
Excellent Tool

scholarly journals Gastrointestinal Stromal Tumor and Ki-67 as a Prognostic Indicator

Cureus ◽  
2022 ◽  
Author(s):  
Kevin J Kadado ◽  
Oaklee L Abernathy ◽  
William J Salyers ◽  
K. James Kallail
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Prognostic Indicator ◽  
Stromal Tumor ◽  
Ki 67

Clinicopathological characteristics of patients with gastrointestinal stromal tumor according to progranulin expression.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 57-57
Author(s):  
Dong-Hoe Koo ◽  
In-Gu Do ◽  
Sukjoong Oh ◽  
Yun-Gyoo Lee ◽  
Kyungeun Kim ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Surgical Resection ◽  
Primary Site ◽  
Mitotic Count ◽  
Stromal Tumor ◽  
Age At Surgery ◽  
Significant Difference ◽  
Mixed Histology ◽  
Exon 11 ◽  
Cd34 Expression

57 Background: As an autocrine growth factor, progranulin (PGRN) has been known to stimulate tumorigenesis and proliferation of several types of cancer cells. However, little is known about the clinicopathological features of patients with gastrointestinal stromal tumor (GIST) according to the PGRN expression. Methods: A retrospective analysis was performed for patients with GIST who underwent curative surgical resection between March 2007 and March 2018. PGRN expression in tumor cells was evaluated by immunohistochemical (IHC) analysis and semi-quantitatively categorized (no expression, 0; weak, 1+; moderate, 2+; strong, 3+). High expression was considered for tumors graded 2+ or 3+ staining intensity. Results: A total of 54 patients were analyzed, and 31 patients (57%) were male. Median age at surgery was 60 years (range, 33-79), and the most common primary site was stomach (36 patients, 67%). Spindle histology was observed in 35 patients (65%). Median tumor size was 8 cm (range, 2-47), and low mitotic count (≤ 5/50 HPF) was observed in 18 patients (33%). According to the modified NIH classification, 42 patients (78%) were grouped into high risk. With IHC evaluation, KIT and CD34 expression were observed in 51 patients (94%) and 40 patients (80%), respectively, and 27 patients (50%) had high PGRN-expressing tumors. Among the 34 patients whose tumors were genotyped, 25 patients (74%) had an exon 11 mutation, and D842V was observed in 3 patients (9%). According to the PGRN expression, high PGRN-expressing tumors had more epithelioid/mixed histology (68% vs. 32%; p = 0.046), and KIT exon 11 mutation (76% vs. 24%; p = 0.037). Regarding other clinicopathological characters, such as sex, age at surgery, primary site, size, mitotic count, risk classification, and KIT/CD34 expression, there was no significant difference between high PGRN-expressing tumors and low PGRN-expressing tumors. Conclusions: High PGRN-expressing GISTs had more epithelioid/mixed histology and more KIT exon 11 mutation in GIST patients who underwent curative surgical resection.

Intramural gastric hematoma imitating a gastrointestinal stromal tumor – case report and literature review

2017 ◽  
Vol 89 (2) ◽  
pp. 62-65 ◽  
Author(s):  
Arkadiusz Spychała ◽  
Piotr Nowaczyk ◽  
Aleksandra Budnicka ◽  
Ewa Antoniewicz ◽  
Dawid Murawa
Keyword(s):  
Case Report ◽  
Gastrointestinal Stromal Tumor ◽  
Ct Scan ◽  
Histopathological Examination ◽  
Posterior Wall ◽  
Stromal Tumor ◽  
Abdominal Ct ◽  
Ki 67 ◽  
Abdominal Ct Scan

The article presents a case report of a patient with an intramural gastric hematoma. Diagnostic examinations were suggestive of a suspected gastrointestinal stromal tumor Normal image was observed in gastroscopic examination while abdominal CT scan revealed a nodular lesion along the greater curvature of the stomach extending from the posterior wall and adjoining the pancreas and the spleen. The patient was qualified for surgical treatment. Laparotomy was performed followed by total gastric resection and Roux-en-Y reconstruction of the gastrointestinal tract. Post-operative histopathological examination revealed the presence of an extensive hematoma penetrating the perigastric fat tissue along with numerous hemosiderinophages and segmental indicators of formation of inflammatory granulation tissue suggestive of a chronic nature of the lesion. Immunohistochemical GIST assays (CD117, DOG-1, CD34, CD31, SMA, S-100, CKAE1/AE3, Ki-67) were negative. No complications were observed in the post-operative course. Patient is subject to continued follow-up and observation. Follow-up gastroscopy and abdominal CT scan performed 6 months after the surgery revealed an unremarkable image.

scholarly journals CD133 and Ki-67 expression is associated with gastrointestinal stromal tumor prognosis

2013 ◽  
Vol 6 (5) ◽  
pp. 1289-1294 ◽  
Author(s):  
CANRONG LU ◽  
LICHENG LIU ◽  
XIN WU ◽  
WENTONG XU
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Stromal Tumor ◽  
Ki 67 ◽  
Tumor Prognosis

scholarly journals Mutations in ALK and TSC1 in a gastrointestinal stromal tumor: a case report

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qingzhi Song ◽  
Guan Li ◽  
Zhuofei Li ◽  
Sheng Ao ◽  
Jianing Hou ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Gastrointestinal Stromal Tumors ◽  
Gene Mutations ◽  
Genetic Mutation ◽  
Stromal Tumor ◽  
Biological Behavior ◽  
Preoperative Imaging ◽  
Missense Mutations ◽  
Ki 67 ◽  
Stromal Tumors

Abstract Background Gastrointestinal stromal tumors rarely occur in children, but when they do, their biological behavior and histopathological patterns differ from those of adults. Case presentation A 13-year-old boy with a gastrointestinal stromal tumor was characterized by a rare genetic mutation. The patient complained of “fatigue with intermittent abdominal pain for 1 month”. According to the preoperative imaging examination, gastroscopy, and gastroscopic biopsy, the patient was diagnosed with a gastric stromal tumor. Postoperative pathology showed that the tumor cells were fusiform and ovoid, and mitotic figures were easily seen. Immunohistochemistry revealed that the tumor was S-100(+), SOX10(−), CD34(+), SMA(partially+), DOG-1(+), CD117(+), KI-67 (positive for 20% + of the subjects and 40% + of the hotspots), and SDHB(−). Genetic tests showed missense mutations in ALK and TSC1. With surgical treatment, the tumor was completely removed. The patient recovered well and was discharged on the ninth day after the operation. He is currently under follow-up. Conclusions In this case involving a patient with a gastrointestinal stromal tumor, immunohistochemistry indicated that the tumor was an "SDH-deficient type", and gene detection showed no KIT or PDGFRA mutation but rare ALK and TSC1 mutations, which adds to the knowledge of the types of gene mutations in children with gastrointestinal stromal tumors.

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