scholarly journals Global expression profile in low grade meningiomas and schwannomas shows upregulation of PDGFD, CDH1 and SLIT2 compared to their healthy tissue

2014 ◽  
Vol 32 (6) ◽  
pp. 2327-2334 ◽  
Author(s):  
MIGUEL TORRES-MARTIN ◽  
LUIS LASSALETTA ◽  
ALBERTO ISLA ◽  
JOSE M. DE CAMPOS ◽  
GIOVANNY R. PINTO ◽  
...  
Keyword(s):  
Expression Profile ◽  
Healthy Tissue ◽  
Low Grade ◽  
Global Expression Profile

scholarly journals Gene expression profile in functioning and non-functioning nodules of autonomous multinodular goiter from an area of iodine deficiency: unexpected common characteristics between the two entities

2021 ◽  
Author(s):  
P. Agretti ◽  
G. De Marco ◽  
E. Ferrarini ◽  
C. Di Cosmo ◽  
L. Montanelli ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Multinodular Goiter ◽  
Kinase Inhibitor ◽  
Wnt Signaling Pathway ◽  
Iodine Intake ◽  
Healthy Tissue ◽  
Specific Gene ◽  
Complement Components

Abstract Purpose Toxic multinodular goiter is a heterogeneous disease associated with hyperthyroidism frequently detected in areas with deficient iodine intake, and functioning and non-functioning nodules, characterized by increased proliferation but opposite functional activity, may coexist in the same gland. To understand the distinct molecular pathology of each entity present in the same gland, the gene expression profile was evaluated by using the Affymetrix technology. Methods Total RNA was extracted from nodular and healthy tissues of two patients and double-strand cDNA was synthesized. Biotinylated cRNA was obtained and, after chemical fragmentation, was hybridized on U133A and B arrays. Each array was stained and the acquired images were analyzed to obtain the expression levels of the transcripts. Both functioning and non-functioning nodules were compared versus healthy tissue of the corresponding patient. Results About 16% of genes were modulated in functioning nodules, while in non-functioning nodules only 9% of genes were modulated with respect to the healthy tissue. In functioning nodules of both patients and up-regulation of cyclin D1 and cyclin-dependent kinase inhibitor 1 was observed, suggesting the presence of a possible feedback control of proliferation. Complement components C1s, C7 and C3 were down-regulated in both types of nodules, suggesting a silencing of the innate immune response. Cellular fibronectin precursor was up-regulated in both functioning nodules suggesting a possible increase of endothelial cells. Finally, Frizzled-1 was down-regulated only in functioning nodules, suggesting a role of Wnt signaling pathway in the proliferation and differentiation of these tumors. None of the thyroid-specific gene was deregulated in microarray analysis. Conclusion In conclusion, the main finding from our data is a similar modulation for both kinds of nodules in genes possibly implicated in thyroid growth.

Hormone receptor expression profile of low-grade serous ovarian cancers

2017 ◽  
Vol 145 (2) ◽  
pp. 352-360 ◽  
Author(s):  
Marianna Buttarelli ◽  
Floriana Mascilini ◽  
Gian Franco Zannoni ◽  
Alessandra Ciucci ◽  
Enrica Martinelli ◽  
...  
Keyword(s):  
Expression Profile ◽  
Hormone Receptor ◽  
Receptor Expression ◽  
Low Grade ◽  
Ovarian Cancers ◽  
Hormone Receptor Expression

scholarly journals Impact of Nonsense-mediated mRNA Decay on the Global Expression Profile of Budding Yeast

PLoS Genetics ◽  
2005 ◽  
Vol preprint (2006) ◽  
pp. e203
Author(s):  
Qiaoning Guan ◽  
Wei Zheng ◽  
Shijie Tang ◽  
Xiaosong Liu ◽  
Robert A. Zinkel ◽  
...  
Keyword(s):  
Expression Profile ◽  
Mrna Decay ◽  
Budding Yeast ◽  
Global Expression Profile ◽  
Nonsense Mediated Mrna Decay

scholarly journals Global expression profile and global genome methylation signatures in male patients with androgenetic alopecia

2020 ◽  
Vol 34 (5) ◽  
Author(s):  
L.A. Martinez‐Jacobo ◽  
C.I. Ancer‐Arellano ◽  
C.D. Villarreal‐ Villarreal ◽  
R. Ortiz‐Lopez ◽  
M. Montufar‐Martinez ◽  
...  
Keyword(s):  
Expression Profile ◽  
Androgenetic Alopecia ◽  
Genome Methylation ◽  
Global Expression Profile ◽  
Male Patients

Use of global expression profile from non-small cell lung carcinoma (NSCLC) surgical samples to predict response to pemetrexed (P)

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 2542-2542
Author(s):  
J. De Castro ◽  
C. Belda-Iniesta ◽  
R. Machado-Pinilla ◽  
P. Cejas ◽  
V. Rodriguez-Fanjul ◽  
...  
Keyword(s):  
Expression Profile ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Global Expression Profile

scholarly journals Global expression profile of tumor stem-like cells isolated from MMQ rat prolactinoma cell

2017 ◽  
Vol 17 (1) ◽  
Author(s):  
Zhipeng Su ◽  
Lin Cai ◽  
Jianglong Lu ◽  
Chuzhong Li ◽  
Songbai Gui ◽  
...  
Keyword(s):  
Expression Profile ◽  
Global Expression Profile

scholarly journals Expression profile analysis of two antisense lncRNAs to improve prognosis prediction of colorectal adenocarcinoma

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Milad Shademan ◽  
Azam Naseri Salanghuch ◽  
Khadijeh Zare ◽  
Morteza Zahedi ◽  
Mohammad Ali Foroughi ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Expression Profile ◽  
Antisense Rna ◽  
Advanced Adenoma ◽  
Low Grade ◽  
Antisense Transcripts ◽  
Expression Levels ◽  
Prognosis Prediction ◽  
Wide Range ◽  
Antisense Lncrnas

Abstract Background Long noncoding RNAs (lncRNAs) are involved in different pathogenesis pathways including cancer pathogenesis. The adenoma-carcinoma pathway in colorectal cancer may involve the aberrant and variable gene expression of regulatory RNAs. This study was conducted to analyse the expression and prognosis prediction ability of two natural antisense transcripts, protein kinase C theta antisense RNA 1 (PRKCQ-AS1), and special AT-rich sequence binding protein 1 antisense RNA 1 (SATB1-AS1) in colorectal low-grade adenoma, advanced adenoma, and adenocarcinomas. Methods In this study, from two RNA-seq analyses of CCAT1-ko cells and colorectal carcinoma biopsies having diminished and increased levels of CCAT1 transcription, respectively, we nominated two antisense lncRNAs of PRKCQ-AS1 and SATB1-AS1. Samples from colorectal low-grade adenomas, advanced adenomas, adenocarcinomas, and adjacent tissue were subjected to RT-qPCR to determine the expression of PRKCQ-AS1, SATB1-AS1 along with colon cancer-associated transcript 1 (CCAT1) and cMYC. In addition, we used different bioinformatics analyses and webservers (including GEPIA 2, TCGA, and CancerMine) to elucidate the prognosis prediction value, the expression correlation of sense–antisense pair of genes, and the expression profile of these antisense transcripts at the presence or absence of mutations in the driver genes, or the corresponding sense genes. Results PRKCQ-AS1 showed a wide range of expression levels in colorectal adenoma, advanced adenoma, and adenocarcinoma. Upregulation of PRKCQ-AS1 was related to a significant decrease in survival of colorectal cancer (CRC) patients. The expression levels of PRKCQ-AS1 and PRKCQ were strong and significantly concordant in normal and cancerous colorectal tissues. While SATB1-AS1 showed a wide range of expression in colorectal adenoma, advanced adenoma, and adenocarcinoma as well, its expression was not related to a decrease in survival of CRC patients. The expression levels of SATB1-AS1 and SATB1 (the sense gene) were not strong in normal colorectal tissues. In addition, where SATB1 gene was mutated, the expression of SATB1-AS1 was significantly downregulated. Conclusions We found the expression of PRKCQ-AS1 and SATB1-AS1 at a given stage of CRC very variable, and not all biopsy samples showed the increased expression of these antisense transcripts. PRKCQ-AS1 in contrast to SATB1-AS1 showed a significant prognostic value. Since a significantly concordant expression was observed for SATB1-AS1 and SATB1 in only cancerous, and for PRKCQ-AS1 and PRKCQ in both normal and cancerous colorectal tissues, it can be concluded that common mechanisms may regulate the expression of these sense and antisense genes.

Global Expression Profile of Aspergillus fumigatus Conidia During Interaction With Murine Macrophage

2008 ◽  
Vol 121 (2) ◽  
pp. S134-S134 ◽  
Author(s):  
J SHANKAR ◽  
S UPADHYAY ◽  
S GUPTA ◽  
S BASIR ◽  
P SARMA ◽  
...  
Keyword(s):  
Aspergillus Fumigatus ◽  
Expression Profile ◽  
Murine Macrophage ◽  
Global Expression Profile
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