scholarly journals Global expression profile and global genome methylation signatures in male patients with androgenetic alopecia

2020 ◽  
Vol 34 (5) ◽  
Author(s):  
L.A. Martinez‐Jacobo ◽  
C.I. Ancer‐Arellano ◽  
C.D. Villarreal‐ Villarreal ◽  
R. Ortiz‐Lopez ◽  
M. Montufar‐Martinez ◽  
...  
Keyword(s):  
Expression Profile ◽  
Androgenetic Alopecia ◽  
Genome Methylation ◽  
Global Expression Profile ◽  
Male Patients

scholarly journals Effect of Pumpkin Seed Oil on Hair Growth in Men with Androgenetic Alopecia: A Randomized, Double-Blind, Placebo-Controlled Trial

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Young Hye Cho ◽  
Sang Yeoup Lee ◽  
Dong Wook Jeong ◽  
Eun Jung Choi ◽  
Yun Jin Kim ◽  
...  
Keyword(s):  
Placebo Group ◽  
Hair Growth ◽  
Seed Oil ◽  
Scalp Hair ◽  
Treated Group ◽  
Androgenetic Alopecia ◽  
Double Blind ◽  
Pumpkin Seed ◽  
Male Patients ◽  
Pumpkin Seed Oil

Pumpkin seed oil (PSO) has been shown to block the action of 5-alpha reductase and to have antiandrogenic effects on rats. This randomized, placebo-controlled, double-blind study was designed to investigate the efficacy and tolerability of PSO for treatment of hair growth in male patients with mild to moderate androgenetic alopecia (AGA). 76 male patients with AGA received 400 mg of PSO per day or a placebo for 24 weeks. Change over time in scalp hair growth was evaluated by four outcomes: assessment of standardized clinical photographs by a blinded investigator; patient self-assessment scores; scalp hair thickness; and scalp hair counts. Reports of adverse events were collected throughout the study. After 24 weeks of treatment, self-rated improvement score and self-rated satisfaction scores in the PSO-treated group were higher than in the placebo group (P = 0.013, 0.003). The PSO-treated group had more hair after treatment than at baseline, compared to the placebo group (P<0.001). Mean hair count increases of 40% were observed in PSO-treated men at 24 weeks, whereas increases of 10% were observed in placebo-treated men (P<0.001). Adverse effects were not different in the two groups.

Topical valproic acid increases the hair count in male patients with androgenetic alopecia: A randomized, comparative, clinical feasibility study using phototrichogram analysis

2014 ◽  
Vol 41 (4) ◽  
pp. 285-291 ◽  
Author(s):  
Seong Jin Jo ◽  
Hyoseung Shin ◽  
Young Woon Park ◽  
Seung Hwan Paik ◽  
Won Seok Park ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Feasibility Study ◽  
Androgenetic Alopecia ◽  
Male Patients

scholarly journals Impact of Nonsense-mediated mRNA Decay on the Global Expression Profile of Budding Yeast

PLoS Genetics ◽  
2005 ◽  
Vol preprint (2006) ◽  
pp. e203
Author(s):  
Qiaoning Guan ◽  
Wei Zheng ◽  
Shijie Tang ◽  
Xiaosong Liu ◽  
Robert A. Zinkel ◽  
...  
Keyword(s):  
Expression Profile ◽  
Mrna Decay ◽  
Budding Yeast ◽  
Global Expression Profile ◽  
Nonsense Mediated Mrna Decay

scholarly journals Histopathological Evidence of Occipital Involvement in Male Androgenetic Alopecia

2021 ◽  
Vol 8 ◽  
Author(s):  
Saranya Khunkhet ◽  
Kumutnart Chanprapaph ◽  
Suthinee Rutnin ◽  
Poonkiat Suchonwanit
Keyword(s):  
Donor Site ◽  
Hair Follicles ◽  
Androgenetic Alopecia ◽  
Occipital Region ◽  
Terminal Hair ◽  
Male Patients ◽  
The Mean ◽  
Scalp Biopsy ◽  
Control Study ◽  
Histopathological Evidence

Background: The occipital region of the scalp is generally accepted as an unaffected area of androgenetic alopecia (AGA) for both genders. However, evidence of AGA involving the occipital scalp has been demonstrated in women; meanwhile, it is unclear whether occipital involvement also occurs in men.Objective: We aimed to determine if there is occipital involvement in men with AGA.Methods: This case-control study compared hair counts of scalp biopsy specimens from the occipital region of 82 men with Hamilton-Norwood III-VII and 82 unaffected men.Results: The mean ages of men with AGA and controls were 40.1 ± 8.9 and 38.6 ± 10.5 years, respectively (P = 0.291). A significant decrease in total hair follicles, terminal hair follicles, follicular units and terminal to vellus (T:V) ratio, along with a significant increase in follicular stelae was indicated in the AGA group compared to controls (all P &lt; 0.05). Subgroup analyses revealed that average counts of total hair follicles, terminal hair follicles and T:V ratios were also significantly lower in males with Hamilton-Norwood VI and VII than in controls (all P &lt; 0.05). There were no correlations between increasing age and hair count parameters, but a significant negative association was found between total follicle numbers and disease duration (r = −0.23, P = 0.02).Conclusions: AGA can involve the occipital area of male patients with advanced disease. Therefore, the occiput of particular cases should not be used to determine reference data for normal scalp hair, and preoperative measurements of miniaturized hairs in the donor site are strongly recommended in all persons undergoing hair transplantation.

Relating Hair Growth Theory and Experimental Evidence to Practical Hair Transplantation

1994 ◽  
Vol 11 (4) ◽  
pp. 305-310 ◽  
Author(s):  
Bobby L. Limmer ◽  
Ronald Razmi ◽  
Thomas Davis ◽  
Charles Stevens
Keyword(s):  
Experimental Evidence ◽  
Hair Growth ◽  
Androgenetic Alopecia ◽  
Growth Theory ◽  
Follicular Growth ◽  
Hair Transplantation ◽  
Terminal Hair ◽  
Male Patients ◽  
Hair Shafts ◽  
Germinal Cells

Hair transplantation methods as generally practiced utilize grafting of full follicles. Recent experimental evidence suggests that germinal cells responsible for follicular growth and differentiation may reside in specific localized areas within the follicle. This study was performed to relate experimental evidence to practical hair transplantation and to discuss results obtained from implantation of ½ follicular grafts. The study was done on four male patients with androgenetic alopecia who underwent transplantation with follicular half autografts. A total of 697 grafts of the upper ½ follicles and 694 grafts of lower ½ follicles were implanted. The results demonstrated that 50 hair shafts were produced from 697 upper ½ grafts, and 152 hair shafts from 694 lower ½ grafts. The conclusion is that the low percentage of terminal hair growth from ½ follicular grafts preclude this technique as an alternative method for cosmetic hair transplantation.

Use of global expression profile from non-small cell lung carcinoma (NSCLC) surgical samples to predict response to pemetrexed (P)

2008 ◽  
Vol 26 (15_suppl) ◽  
pp. 2542-2542
Author(s):  
J. De Castro ◽  
C. Belda-Iniesta ◽  
R. Machado-Pinilla ◽  
P. Cejas ◽  
V. Rodriguez-Fanjul ◽  
...  
Keyword(s):  
Expression Profile ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Small Cell ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma ◽  
Global Expression Profile

Assessment of the Oxidative Stress Status in Androgenetic Alopecia in Egyptian Men

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Heba Mahmoud Diab ◽  
Marwa Yassin Soltan ◽  
Nashwa El-Khazragy ◽  
Aliaa Mohamed Atef Raafat
Keyword(s):  
Hair Follicle ◽  
Positive Family History ◽  
Androgenetic Alopecia ◽  
University Hospitals ◽  
Oxidative Stress Status ◽  
Anagen Phase ◽  
History Of ◽  
Anagen Hair ◽  
Male Patients ◽  
Control Study

Abstract Background Androgenetic alopecia (AGA) is the most common type of hair loss in men. It is commonly known as a male pattern baldness. It is characterized by a stepwise miniaturization of the hair follicle, resulting from alteration in the hair cycle dynamics, leading to vellus transformation of terminal hair follicle. In AGA, the duration of anagen phase gradually decreases and that of telogen phase increases, the maximum length of the new anagen hair becomes shorter than that of its predecessor, leading to miniaturization and eventually a bald appearance. Aim of the Work To assess the expression of NRF2 in the scalp of men with androgenetic alopecia. Patients and Methods This case control study included 28 male patients whose age ranged from 18 to 45 years old. They were diagnosed as having AGA according to Norwood-Hamilton scale. Further, 28 age and sex matched healthy male controls were recruited. All patients and controls were recruited from the dermatology outpatient clinic of Ain-Shams University Hospitals, during the period of September 2018 to April 2019. Results A group of Twenty-eight male patients with AGA were recruited to the study. The of patients ranged from 18 to 45 years (mean = 33.46 years ± 9.9 SD). Twenty-eight age matched male healthy volunteers without AGA were e recruited. The majority of AGA patients had positive family history of AGA in their first degree relatives. None of our patients had a medical history of systemic diseases like diabetes mellitus or hypertension. Conclusion The current study showed that alteration of Nrf2 levels may play an important role in the pathogenesis of AGA.

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