scholarly journals Downregulation of Hsp70 inhibits apoptosis induced by sialic acid-binding lectin (leczyme)

2013 ◽  
Vol 31 (1) ◽  
pp. 13-18 ◽  
Author(s):  
TAKEO TATSUTA ◽  
MASAHIRO HOSONO ◽  
YUKIKO OGAWA ◽  
KYOKO INAGE ◽  
SHIGEKI SUGAWARA ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Sialic Acid Binding ◽  
Binding Lectin

scholarly journals Porcine Arterivirus Infection of Alveolar Macrophages Is Mediated by Sialic Acid on the Virus

2004 ◽  
Vol 78 (15) ◽  
pp. 8094-8101 ◽  
Author(s):  
Peter L. Delputte ◽  
Hans J. Nauwynck
Keyword(s):  
Sialic Acid ◽  
Alveolar Macrophages ◽  
Sialic Acids ◽  
Respiratory Syndrome Virus ◽  
Specific Monoclonal Antibody ◽  
Neuraminidase Treatment ◽  
Acid Binding Protein ◽  
Sialic Acid Binding ◽  
High Mannose ◽  
Binding Lectin

ABSTRACT Recently, we showed that porcine sialoadhesin (pSn) mediates internalization of the arterivirus porcine reproductive and respiratory syndrome virus (PRRSV) in alveolar macrophages (Vanderheijden et al., J. Virol. 77:8207-8215, 2003). In rodents and humans, sialoadhesin, or Siglec-1, has been described as a macrophage-restricted molecule and to specifically bind sialic acid moieties. In the current study, we investigated whether pSn is a sialic acid binding protein and, whether so, whether this property is important for its function as a PRRSV receptor. Using untreated and neuraminidase-treated sheep erythrocytes, we showed that pSn binds sialic acid. Furthermore, pSn-specific monoclonal antibody 41D3, which blocks PRRSV infection, inhibited this interaction. PRRSV attachment to and infection of porcine alveolar macrophages (PAM) were both shown to be dependent on the presence of sialic acid on the virus: neuraminidase treatment of virus but not of PAM blocked infection and reduced attachment. Enzymatic removal of all N-linked glycans on the virus with N-glycosidase F reduced PRRSV infection, while exclusive removal of nonsialylated N-linked glycans of the high-mannose type with endoglycosidase H had no significant effect. Free sialyllactose and sialic acid containing (neo)glycoproteins reduced infection, while lactose and (neo)glycoproteins devoid of sialic acids had no significant effect. Studies with linkage-specific neuraminidases and lectins indicated that α2-3- and α2-6-linked sialic acids on the virion are important for PRRSV infection of PAM. From these results, we conclude that pSn is a sialic acid binding lectin and that interactions between sialic acid on the PRRS virion and pSn are essential for PRRSV infection of PAM.

scholarly journals Involvement of ER stress in apoptosis induced by sialic acid-binding lectin (leczyme) from bullfrog eggs

2013 ◽  
Vol 43 (6) ◽  
pp. 1799-1808 ◽  
Author(s):  
TAKEO TATSUTA ◽  
MASAHIRO HOSONO ◽  
YUKI MIURA ◽  
SHIGEKI SUGAWARA ◽  
YUKIKO KARIYA ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Er Stress ◽  
Sialic Acid Binding ◽  
Binding Lectin

A sialic acid-binding lectin from the legume Maackia fauriei: comparison with lectins from M. amurensis

Plant Science ◽  
2004 ◽  
Vol 167 (6) ◽  
pp. 1315-1321 ◽  
Author(s):  
Bum Soo Kim ◽  
Kyung Taik Oh ◽  
Due Hyeon Cho ◽  
Yun Jung Kim ◽  
Wan Mo Koo ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Sialic Acid Binding ◽  
Binding Lectin

scholarly journals Sialic acid-binding lectin from bullfrog eggs inhibits human malignant mesothelioma cell growth in vitro and in vivo

PLoS ONE ◽  
2018 ◽  
Vol 13 (1) ◽  
pp. e0190653 ◽  
Author(s):  
Takeo Tatsuta ◽  
Toshiyuki Satoh ◽  
Shigeki Sugawara ◽  
Akiyoshi Hara ◽  
Masahiro Hosono
Keyword(s):  
Sialic Acid ◽  
Cell Growth ◽  
Malignant Mesothelioma ◽  
Sialic Acid Binding ◽  
Mesothelioma Cell ◽  
Binding Lectin

Chemical Synthesis of a Synthetic Analogue of the Sialic Acid-Binding Lectin Siglec-7

ChemBioChem ◽  
2014 ◽  
Vol 15 (17) ◽  
pp. 2503-2507 ◽  
Author(s):  
Masayuki Izumi ◽  
Akihisa Otsuki ◽  
Mika Nishihara ◽  
Ryo Okamoto ◽  
Yasuhiro Kajihara
Keyword(s):  
Sialic Acid ◽  
Chemical Synthesis ◽  
Synthetic Analogue ◽  
Sialic Acid Binding ◽  
Binding Lectin

scholarly journals Synergistic anti-tumor effect of bullfrog sialic acid-binding lectin and pemetrexed in malignant mesothelioma

Oncotarget ◽  
2017 ◽  
Vol 8 (26) ◽  
pp. 42466-42477 ◽  
Author(s):  
Toshiyuki Satoh ◽  
Takeo Tatsuta ◽  
Shigeki Sugawara ◽  
Akiyoshi Hara ◽  
Masahiro Hosono
Keyword(s):  
Sialic Acid ◽  
Malignant Mesothelioma ◽  
Sialic Acid Binding ◽  
Binding Lectin
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