scholarly journals Determination of the optimal time for radioiodine therapy in anaplastic thyroid carcinoma using the adenovirus-mediated transfer of sodium iodide symporter gene

2013 ◽  
Vol 29 (4) ◽  
pp. 1666-1670 ◽  
Author(s):  
YOUNG SO ◽  
YONG JIN LEE ◽  
WON WOO LEE ◽  
JUNE-KEY CHUNG
Keyword(s):  
Thyroid Carcinoma ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Anaplastic Thyroid Carcinoma ◽  
Optimal Time ◽  
Sodium Iodide Symporter

Reintroducing the Sodium–Iodide Symporter to Anaplastic Thyroid Carcinoma

Thyroid ◽  
2017 ◽  
Vol 27 (12) ◽  
pp. 1534-1543 ◽  
Author(s):  
Kathrin A. Schmohl ◽  
Patrick Dolp ◽  
Christina Schug ◽  
Kerstin Knoop ◽  
Kathrin Klutz ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Sodium Iodide ◽  
Anaplastic Thyroid Carcinoma ◽  
Sodium Iodide Symporter

scholarly journals Network analysis reveals essential proteins that regulate sodium-iodide symporter expression in anaplastic thyroid carcinoma

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Hassan Rakhsh-Khorshid ◽  
Hilda Samimi ◽  
Shukoofeh Torabi ◽  
Sayed Mahmoud Sajjadi-Jazi ◽  
Hamed Samadi ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Information Flow ◽  
Protein Interaction ◽  
Biological Networks ◽  
Protein Interaction Network ◽  
Sodium Iodide ◽  
Interaction Network ◽  
Anaplastic Thyroid Carcinoma ◽  
Sodium Iodide Symporter ◽  
Essential Proteins

AbstractAnaplastic thyroid carcinoma (ATC) is the most rare and lethal form of thyroid cancer and requires effective treatment. Efforts have been made to restore sodium-iodide symporter (NIS) expression in ATC cells where it has been downregulated, yet without complete success. Systems biology approaches have been used to simplify complex biological networks. Here, we attempt to find more suitable targets in order to restore NIS expression in ATC cells. We have built a simplified protein interaction network including transcription factors and proteins involved in MAPK, TGFβ/SMAD, PI3K/AKT, and TSHR signaling pathways which regulate NIS expression, alongside proteins interacting with them. The network was analyzed, and proteins were ranked based on several centrality indices. Our results suggest that the protein interaction network of NIS expression regulation is modular, and distance-based and information-flow-based centrality indices may be better predictors of important proteins in such networks. We propose that the high-ranked proteins found in our analysis are expected to be more promising targets in attempts to restore NIS expression in ATC cells.

Novel therapy for anaplastic thyroid carcinoma cells using an oncolytic vaccinia virus carrying the human sodium iodide symporter

Surgery ◽  
2011 ◽  
Vol 150 (6) ◽  
pp. 1040-1047 ◽  
Author(s):  
Sepideh Gholami ◽  
Dana Haddad ◽  
Chun-Hao Chen ◽  
Nanhai G. Chen ◽  
Qian Zhang ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Vaccinia Virus ◽  
Sodium Iodide ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cells ◽  
Sodium Iodide Symporter ◽  
Novel Therapy

In Vitro and In Vivo Properties of a Human Anaplastic Thyroid Carcinoma Cell Line Transfected with the Sodium Iodide Symporter Gene

Thyroid ◽  
2004 ◽  
Vol 14 (11) ◽  
pp. 889-895 ◽  
Author(s):  
Yong Jin Lee ◽  
June-Key Chung ◽  
Jae Hoon Shin ◽  
Joo Hyun Kang ◽  
Jae Min Jeong ◽  
...  
Keyword(s):  
Thyroid Carcinoma ◽  
Cell Line ◽  
Sodium Iodide ◽  
Carcinoma Cell ◽  
Anaplastic Thyroid Carcinoma ◽  
Carcinoma Cell Line ◽  
Sodium Iodide Symporter ◽  
Thyroid Carcinoma Cell

scholarly journals Autophagy activity is associated with membranous sodium iodide symporter expression and clinical response to radioiodine therapy in non-medullary thyroid cancer

Autophagy ◽  
2016 ◽  
Vol 12 (7) ◽  
pp. 1195-1205 ◽  
Author(s):  
Theo S. Plantinga ◽  
Marika H. Tesselaar ◽  
Hans Morreau ◽  
Eleonora P. M. Corssmit ◽  
Brigith K. Willemsen ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Clinical Response ◽  
Sodium Iodide ◽  
Medullary Thyroid Cancer ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter ◽  
Medullary Thyroid ◽  
Autophagy Activity

scholarly journals In vivo long-term imaging and radioiodine therapy by sodium-iodide symporter gene expression using a lentiviral system containing ubiquitin C promoter

2007 ◽  
Vol 6 (7) ◽  
pp. 1130-1135 ◽  
Author(s):  
Hyun Joo Kim ◽  
Yong Hyun Jeon ◽  
Joo Hyun Kang ◽  
Yong Jin Lee ◽  
Kwang Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter

scholarly journals Thyroid Carcinoma with Pituitary Metastases: 2 Case Reports and Literature Review

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Weiying Lim ◽  
Dawn Shaoting Lim ◽  
Chiaw Ling Chng ◽  
Adoree Yiying Lim
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Carcinoma ◽  
Radioiodine Therapy ◽  
Follicular Thyroid Carcinoma ◽  
Case Reports ◽  
Anaplastic Thyroid Cancer ◽  
Anaplastic Thyroid Carcinoma ◽  
Pituitary Metastases ◽  
History Of ◽  
Loss Of Appetite

We present 2 patients with pituitary metastases from thyroid carcinoma—the first from anaplastic thyroid carcinoma and the second from follicular thyroid carcinoma. The first patient, a 50-year-old lady, presented with 2-week history of hoarseness of voice, dysphagia, dyspnoea, and neck swelling. Imaging revealed metastatic thyroid cancer to lymph nodes and bone. Histology from surgery confirmed anaplastic thyroid cancer. She was found to have pituitary metastases postoperatively when she presented with nonvertiginous dizziness. She subsequently underwent radiotherapy and radioiodine treatment but passed away from complications. The second patient, a 65-year-old lady, presented with loss of appetite and weight with increased goitre size and dyspnoea. Surgery was performed in view of compressive symptoms and histology confirmed follicular thyroid carcinoma. Imaging revealed metastases to bone, lung, and pituitary. She also had panhypopituitarism with hyperprolactinemia and diabetes insipidus. She received radioiodine therapy but eventually passed away from complications.

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