scholarly journals In vivo long-term imaging and radioiodine therapy by sodium-iodide symporter gene expression using a lentiviral system containing ubiquitin C promoter

2007 ◽  
Vol 6 (7) ◽  
pp. 1130-1135 ◽  
Author(s):  
Hyun Joo Kim ◽  
Yong Hyun Jeon ◽  
Joo Hyun Kang ◽  
Yong Jin Lee ◽  
Kwang Kim ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter

scholarly journals Evaluation of Lentiviral-Mediated Expression of Sodium Iodide Symporter in Anaplastic Thyroid Cancer and the Efficacy of In Vivo Imaging and Therapy

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Chien-Chih Ke ◽  
Ya-Ju Hsieh ◽  
Luen Hwu ◽  
Fu-Hui Wang ◽  
Fu-Du Chen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sodium Iodide ◽  
Cell Function ◽  
Tumor Imaging ◽  
Promising Result ◽  
Anaplastic Thyroid Cancer ◽  
Anaplastic Thyroid Carcinoma ◽  
Sodium Iodide Symporter

Anaplastic thyroid carcinoma (ATC) is one of the most deadly cancers. With intensive multimodalities of treatment, the survival remains low. ATC is not sensitive to131I therapy due to loss of sodium iodide symporter (NIS) gene expression. We have previously generated a stable human NIS-expressing ATC cell line, ARO, and the ability of iodide accumulation was restored. To make NIS-mediated gene therapy more applicable, this study aimed to establish a lentiviral system for transferring hNIS gene to cells and to evaluate the efficacy of in vitro and in vivo radioiodide accumulation for imaging and therapy. Lentivirus containing hNIS cDNA were produced to transduce ARO cells which do not concentrate iodide. Gene expression, cell function, radioiodide imaging and treatment were evaluated in vitro and in vivo. Results showed that the transduced cells were restored to express hNIS and accumulated higher amount of radioiodide than parental cells. Therapeutic dose of131I effectively inhibited the tumor growth derived from transduced cells as compared to saline-treated mice. Our results suggest that the lentiviral system efficiently transferred and expressed hNIS gene in ATC cells. The transduced cells showed a promising result of tumor imaging and therapy.

scholarly journals GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo

2003 ◽  
Vol 8 (3) ◽  
pp. 508-518 ◽  
Author(s):  
Kenneth N Barton ◽  
Donald Tyson ◽  
Hans Stricker ◽  
Young S Lew ◽  
Gregory Heisey ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Therapy ◽  
Sodium Iodide ◽  
Noninvasive Imaging ◽  
Sodium Iodide Symporter ◽  
Gene Therapy Vectors

scholarly journals In Vivo Scintigraphic Imaging of Antitumor Effects by Combined Radioiodine Therapy and Human Sodium Iodide Symporter Gene Immunotherapy

2010 ◽  
Vol 9 (3) ◽  
pp. 7290.2010.00010
Author(s):  
Yun Choi ◽  
Yong Hyun Jeon ◽  
Jin Ho Paik ◽  
Jinkyung Ko ◽  
Dae Han Choi ◽  
...  
Keyword(s):  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter ◽  
Antitumor Effects ◽  
Scintigraphic Imaging

scholarly journals In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas

Gene Therapy ◽  
2002 ◽  
Vol 9 (17) ◽  
pp. 1139-1145 ◽  
Author(s):  
J-Y Cho ◽  
D HY Shen ◽  
W Yang ◽  
B Williams ◽  
T LF Buckwalter ◽  
...  
Keyword(s):  
Animal Model ◽  
Gene Transfer ◽  
In Vivo Imaging ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter

scholarly journals Relationship between Apoptosis Imaging and Radioiodine Therapy in Tumor Cells with Different Sodium Iodide Symporter Gene Expression

2015 ◽  
Vol 14 (1) ◽  
pp. 7290.2014.00050 ◽  
Author(s):  
Kyung Oh Jung ◽  
Hyewon Youn ◽  
Young-Hwa Kim ◽  
Seunghoo Kim ◽  
Juri Na ◽  
...  
Keyword(s):  
Gene Expression ◽  
Tumor Cells ◽  
Sodium Iodide ◽  
Radioiodine Therapy ◽  
Sodium Iodide Symporter ◽  
Apoptosis Imaging

scholarly journals In Vivo Myoblasts Tracking Using the Sodium Iodide Symporter Gene Expression in Dogs

2020 ◽  
Vol 17 ◽  
pp. 317-327 ◽  
Author(s):  
Isabel Punzón ◽  
David Mauduit ◽  
Bryan Holvoet ◽  
Jean-Laurent Thibaud ◽  
Pauline de Fornel ◽  
...  
Keyword(s):  
Gene Expression ◽  
Sodium Iodide ◽  
Sodium Iodide Symporter
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