MORPHOLOGIC CHANGES OF DOXORUBICIN-SENSITIVE AND RESISTANT LOVO CELLS TREATED IN-VITRO BY CALCIUM CHANNELS BLOCKERS

1995 ◽  
Author(s):  
S DANCONA ◽  
M MAZZO
Keyword(s):  
Calcium Channels ◽  
Lovo Cells ◽  
Morphologic Changes ◽  
Calcium Channels Blockers

scholarly journals Modulation of human T-type calcium channels by synthetic cannabinoid receptor agonists in vitro

2021 ◽  
Vol 187 ◽  
pp. 108478
Author(s):  
Chris Bladen ◽  
Somayeh Mirlohi ◽  
Marina Santiago ◽  
Mitchell Longworth ◽  
Michael Kassiou ◽  
...  
Keyword(s):  
Calcium Channels ◽  
Cannabinoid Receptor ◽  
Synthetic Cannabinoid ◽  
Receptor Agonists ◽  
Synthetic Cannabinoid Receptor Agonists

Immunologic Monitoring of Transplant Rejection: Correlation of in vitro Assays with Morphologic Changes on Transplant Biopsy

Nephron ◽  
1978 ◽  
Vol 22 (1-3) ◽  
pp. 208-211 ◽  
Author(s):  
M.R. Garovoy ◽  
P. Gailiunas ◽  
C.B. Carpenter ◽  
G.J. Busch
Keyword(s):  
Transplant Rejection ◽  
Immunologic Monitoring ◽  
Transplant Biopsy ◽  
Morphologic Changes

scholarly journals Influence of l-type slow calcium channels blockers on cardiac, respiratory and motor activity at the intact and poisoned by physostigmine (eserine) of rats during the early ontogeny

2019 ◽  
Vol 17 (3) ◽  
pp. 39-49
Author(s):  
Sergey V. Kuznetsov ◽  
Nataliya N. Kuznetsova ◽  
Polina A. Gaydukova
Keyword(s):  
Calcium Channels ◽  
Motor Activity ◽  
Respiration Rate ◽  
Heart Rhythm ◽  
Early Ontogeny ◽  
Ache Inhibitor ◽  
Channel Blockers ◽  
Infant Rats ◽  
Old Rats ◽  
Calcium Channels Blockers

The effects of calcium-channel blockers (CCBs) (verapamil, nifedipine) on heart rate, respiration rate and motor activity were studied in 3-30-day-old rats. The role of calcium channels in development of disturbances of a heart and respiratory rhythms after introduction to newborn rats of acetylcholinesterase (AChE) inhibitor of physostigmine was revealed. Parameters of functional activity of heart, respiratory and somatomotor systems in case of blockade of calcium channels were studied also under conditions of the activation of cholinoceptive structures caused by an injection to infant rats of AChE inhibitor after premedication by CCBs. It is shown that use of calcium channels blockers leads to development of bradycardia, and verapamil causes more expressed disturbance of a heart rhythm in rats of younger age, while blockade of dihydropyridinic receptors by nifedipine has no ontogenetic specifics. Similar ontogenetic dynamics concerns also reaction of respiratory system. Verapamil have a detrimental effect on respiration, up to a stop, in 3-7-day-old and to a lesser extent in 16-30-day-old infant rats. Nifedipine slightly reduces a respiration rate at younger infant rats, but raises it at the mature rats. The nifedipine injection more in comparison with verapamil changes the level and a pattern of motor activity. Preliminary blockade of calcium channels does not render significant change of reaction at the subsequent introduction of physostigmin.

scholarly journals CARDIO NEUROLOGICAL SYMPTOMS CAUSED BY AN ACUTE POISONING WITH SLOW CALCIUM CHANNEL BLOCKING AGENT (VERAPAMIL)

2020 ◽  
Vol 26 (4) ◽  
pp. 34-39
Author(s):  
Boris Borisovich Yatsinyuk ◽  
◽  
Pavel Pavlovich Gavrikov ◽  
Yulia Vasilyevna Lobur
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Blocking Agent ◽  
Acute Poisoning ◽  
Frequency Of Occurrence ◽  
Hemodynamic Parameters ◽  
Hemodynamic Effects ◽  
Channel Blocking ◽  
Consciousness Disorder ◽  
Calcium Channels Blockers

The research of an analysis of the cardiac hemodynamic effects of an acute chemical trauma with slow calcium channels blockers (verapamil) shows that the depth of disorder of cardiac hemodynamic parameters and the level and frequency of occurrence of consciousness disorder were determined in 46 patients within the period of 2007–2017 in this nosological form of acute poisoning.

Bi2 S3 -Tween 20 Nanodots Loading PI3K Inhibitor, LY294002, for Mild Photothermal Therapy of LoVo Cells In Vitro and In Vivo

2018 ◽  
Vol 7 (22) ◽  
pp. 1800830 ◽  
Author(s):  
Li Song ◽  
Xinghua Dong ◽  
Shuang Zhu ◽  
Chunfang Zhang ◽  
Wenyan Yin ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Pi3k Inhibitor ◽  
Tween 20 ◽  
Pi3k Inhibitor Ly294002 ◽  
Lovo Cells

Voltage-dependent calcium channels in ventricular cells of rainbow trout: effect of temperature changes in vitro

2000 ◽  
Vol 278 (6) ◽  
pp. R1524-R1534 ◽  
Author(s):  
Catherine S. Kim ◽  
Mary D. Coyne ◽  
Judith K. Gwathmey
Keyword(s):  
Rainbow Trout ◽  
Calcium Channels ◽  
Temperature Sensitivity ◽  
Calcium Currents ◽  
Temperature Dependency ◽  
Patch Clamp Technique ◽  
Ventricular Cells ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels

Voltage-dependent calcium channels (VDCC) in ventricular myocytes from rainbow trout ( Oncorhynchus mykiss) were investigated in vitro using the perforated patch-clamp technique, which maintains the integrity of the intracellular milieu. First, we characterized the current using barium as the charge carrier and established the doses of various pharmacological agents to use these agents in additional studies. Second, we examined the current at several physiological temperatures to determine temperature dependency. The calcium currents at 10°C (acclimation temperature) were identified as l-type calcium currents based on their kinetic behavior and response to various calcium channel agonists and antagonists. Myocytes were chilled (4°C) and warmed (18 and 22°C), and the response of VDCC to varying temperatures was observed. There was no significant dependency of the current amplitude and kinetics on temperature. Amplitude decreased 25–36% at 4°C (Q10 ∼1.89) and increased 18% at 18°C (Q10 ∼1.23) in control, Bay K8644 (Bay K)-, and forskolin-enhanced currents. The inactivation rates (τi) did not demonstrate a temperature sensitivity for the VDCC (Q10 1.23–1.92); Bay K treatment, however, increased temperature sensitivity of τi between 10 and 18°C (Q10 3.98). The low Q10 values for VDCC are consistent with a minimal temperature sensitivity of trout myocytes between 4 and 22°C. This low-temperature dependency may provide an important role for sarcolemmal calcium channels in adaptation to varying environmental temperatures in trout.

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