scholarly journals Influence of l-type slow calcium channels blockers on cardiac, respiratory and motor activity at the intact and poisoned by physostigmine (eserine) of rats during the early ontogeny

2019 ◽  
Vol 17 (3) ◽  
pp. 39-49
Author(s):  
Sergey V. Kuznetsov ◽  
Nataliya N. Kuznetsova ◽  
Polina A. Gaydukova
Keyword(s):  
Calcium Channels ◽  
Motor Activity ◽  
Respiration Rate ◽  
Heart Rhythm ◽  
Early Ontogeny ◽  
Ache Inhibitor ◽  
Channel Blockers ◽  
Infant Rats ◽  
Old Rats ◽  
Calcium Channels Blockers

The effects of calcium-channel blockers (CCBs) (verapamil, nifedipine) on heart rate, respiration rate and motor activity were studied in 3-30-day-old rats. The role of calcium channels in development of disturbances of a heart and respiratory rhythms after introduction to newborn rats of acetylcholinesterase (AChE) inhibitor of physostigmine was revealed. Parameters of functional activity of heart, respiratory and somatomotor systems in case of blockade of calcium channels were studied also under conditions of the activation of cholinoceptive structures caused by an injection to infant rats of AChE inhibitor after premedication by CCBs. It is shown that use of calcium channels blockers leads to development of bradycardia, and verapamil causes more expressed disturbance of a heart rhythm in rats of younger age, while blockade of dihydropyridinic receptors by nifedipine has no ontogenetic specifics. Similar ontogenetic dynamics concerns also reaction of respiratory system. Verapamil have a detrimental effect on respiration, up to a stop, in 3-7-day-old and to a lesser extent in 16-30-day-old infant rats. Nifedipine slightly reduces a respiration rate at younger infant rats, but raises it at the mature rats. The nifedipine injection more in comparison with verapamil changes the level and a pattern of motor activity. Preliminary blockade of calcium channels does not render significant change of reaction at the subsequent introduction of physostigmin.

scholarly journals Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal

2019 ◽  
Vol 216 (5) ◽  
pp. 250-253 ◽  
Author(s):  
Paul J. Harrison ◽  
Elizabeth M. Tunbridge ◽  
Annette C. Dolphin ◽  
Jeremy Hall
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Psychiatric Disorders ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Risk Genes ◽  
Voltage Gated ◽  
Voltage Gated Calcium Channels ◽  
Voltage Gated Calcium Channel ◽  
Second Use

SummaryWe reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.

scholarly journals CARDIO NEUROLOGICAL SYMPTOMS CAUSED BY AN ACUTE POISONING WITH SLOW CALCIUM CHANNEL BLOCKING AGENT (VERAPAMIL)

2020 ◽  
Vol 26 (4) ◽  
pp. 34-39
Author(s):  
Boris Borisovich Yatsinyuk ◽  
◽  
Pavel Pavlovich Gavrikov ◽  
Yulia Vasilyevna Lobur
Keyword(s):  
Calcium Channels ◽  
Calcium Channel ◽  
Blocking Agent ◽  
Acute Poisoning ◽  
Frequency Of Occurrence ◽  
Hemodynamic Parameters ◽  
Hemodynamic Effects ◽  
Channel Blocking ◽  
Consciousness Disorder ◽  
Calcium Channels Blockers

The research of an analysis of the cardiac hemodynamic effects of an acute chemical trauma with slow calcium channels blockers (verapamil) shows that the depth of disorder of cardiac hemodynamic parameters and the level and frequency of occurrence of consciousness disorder were determined in 46 patients within the period of 2007–2017 in this nosological form of acute poisoning.

Two calcium channels in basolateral membranes of rabbit ileal epithelial cells

1989 ◽  
Vol 257 (1) ◽  
pp. G86-G93
Author(s):  
F. R. Homaidan ◽  
M. Donowitz ◽  
G. A. Weiland ◽  
G. W. Sharp
Keyword(s):  
Epithelial Cells ◽  
Calcium Channels ◽  
Calcium Channel ◽  
Short Circuit ◽  
Short Circuit Current ◽  
The Other ◽  
Channel Blockers ◽  
Binding Studies ◽  
Rabbit Ileum ◽  
Basolateral Membranes

The actions of three different types of calcium channel blockers on short-circuit current (Isc) in rabbit ileum were studied. These included the phenylalkylamines, verapamil and (l)-desmethoxyverapamil (D888); the dihydropyridines, nifedipine and nitrendipine; and the benzothiazepine, diltiazem. All of the drugs decreased Isc, a change associated with increased Na and Cl absorption. Verapamil and D888 had the largest effects. The dihydropyridine, BAY K 8644, a calcium channel activator, increased Isc and decreased Na and Cl absorption, effects not inhibited by tetrodotoxin. The phenylalkylamines had an additional effect on Isc in the presence of a maximally inhibitory concentration of the dihydropyridines, suggesting the possibility of two distinct calcium channels, one of which is the L-type voltage-activated, dihydropyridine- and phenylalkylamine-sensitive channel, and the other is a channel only sensitive to phenylalkylamines but not to dihydropyridines. [3H]nitrendipine and [3H]D888 binding to an enriched preparation of basolateral membranes from ileal epithelial cells was characterized. Each ligand bound specifically and saturably to an apparently single population of high-affinity sites with [3H]D888 having three times as many binding sites as [3H]nitrendipine. [3H]nitrendipine binding was partially inhibited by verapamil and D888 and was increased by diltiazem; whereas [3H]D888 binding was inhibited completely by verapamil but only partially by nitrendipine and diltiazem. These transport and binding studies suggest the presence of two types of Ca2+ channels in ileal epithelial cells, one of which interacts with the dihydropyridines, the phenylalkylamines, and the benzothiazepines at three different sites and the other channel that only binds the phenylalkylamines.

Branching points of renal resistance arteries are enriched in L-type calcium channels and initiate vasoconstriction

1995 ◽  
Vol 268 (2) ◽  
pp. F251-F257 ◽  
Author(s):  
M. S. Goligorsky ◽  
D. Colflesh ◽  
D. Gordienko ◽  
L. C. Moore
Keyword(s):  
Calcium Channels ◽  
Digital Image Analysis ◽  
Vascular Wall ◽  
Channel Blockers ◽  
Resistance Arteries ◽  
Pacemaker Cells ◽  
Calcium Indicator ◽  
Branching Points ◽  
Enhanced Expression ◽  
Vascular Beds

The morphologic structures responsible for the drop in blood pressure along the preglomerular vasculature are not completely defined. Theoretical and videomicroscopic analyses of nonrenal vascular beds implicate bifurcations of resistance arteries as important sites of hemodynamic regulation. These structures contain pacemaker cells sensitive to calcium channel blockers and appear to initiate vasomotion. In the present study, we examined the possibility of functional diversity of smooth muscle cells along resistance arteries with regard to the density of voltage-gated L-type calcium channels. Staining of microdissected renal resistance arteries with Bodipy-labeled dihydropyridine and analysis by confocal microscopy showed enhanced binding at branching points compared with the distal sites in daughter vessels. Antibodies directed against the alpha 1-subunit of the dihydropyridine-sensitive calcium channels confirmed the enhanced expression of L-type channels predominantly at the sites of bifurcations of renal resistance arteries. Fluorescence digital-image analysis of freshly microdissected branches of cortical radial (interlobular) and arcuate arteries intravitally labeled with a calcium indicator, fluo 3, identified branching points as initiator sites of depolarization-induced intracellular Ca2+ concentration ([Ca2+]i) transients, which propagated along the vascular wall at the rate of 2.0 +/- 0.7 micron/s. Videomicroscopy of blood-perfused rat juxtamedullary resistance arteries showed that branching points exhibit more pronounced contractile responses to KCl-induced depolarization than distal sites along the daughter vessels. Collectively, these results demonstrate that branching points are enriched in L-type calcium channels, a finding that suggests these structures may serve as important regulators of renal hemodynamics.

Spontaneous muscle action potentials are blocked by N-type and P/Q-calcium channels blockers in the rat spinal cord–muscle co-culture system

2005 ◽  
Vol 1034 (1-2) ◽  
pp. 62-70 ◽  
Author(s):  
Kyoji Taguchi ◽  
Masatoshi Shiina ◽  
Keiko Shibata ◽  
Iku Utsunomiya ◽  
Tadashi Miyatake
Keyword(s):  
Spinal Cord ◽  
Calcium Channels ◽  
Action Potentials ◽  
Culture System ◽  
Muscle Action ◽  
Rat Spinal Cord ◽  
Calcium Channels Blockers

Development of L-type calcium channels and a nifedipine-sensitive motor activity in the postnatal mouse spinal cord

1999 ◽  
Vol 11 (10) ◽  
pp. 3481-3487 ◽  
Author(s):  
Z. Jiang ◽  
J. Rempel ◽  
J. Li ◽  
M. A. Sawchuk ◽  
K. P. Carlin ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Calcium Channels ◽  
Motor Activity ◽  
Mouse Spinal Cord
Sign in / Sign up

Export Citation Format

Share Document