scholarly journals Alteration of hTERT full-length variant expression level showed different gene expression profiles and genomic copy number changes in breast cancer

2006 ◽  
Author(s):  
Sun Rha ◽  
Hei Jeung ◽  
Woo Yang ◽  
Jin Kim ◽  
Tae Oh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Copy Number ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Full Length ◽  
Expression Level ◽  
Genomic Copy Number ◽  
Length Variant ◽  
Copy Number Changes

scholarly journals Identification of Breast Cancer Subtype-Specific Biomarkers by Integrating Copy Number Alterations and Gene Expression Profiles

Medicina ◽  
2021 ◽  
Vol 57 (3) ◽  
pp. 261
Author(s):  
Claudia Cava ◽  
Mirko Pisati ◽  
Marco Frasca ◽  
Isabella Castiglioni
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Copy Number ◽  
Molecular Mechanisms ◽  
Expression Profiles ◽  
Breast Cancer Subtype ◽  
Gene Expression Profiles ◽  
Copy Number Alterations ◽  
Luminal A ◽  
Luminal B

Background and Objectives: Breast cancer is a heterogeneous disease categorized into four subtypes. Previous studies have shown that copy number alterations of several genes are implicated with the development and progression of many cancers. This study evaluates the effects of DNA copy number alterations on gene expression levels in different breast cancer subtypes. Materials and Methods: We performed a computational analysis integrating copy number alterations and gene expression profiles in 1024 breast cancer samples grouped into four molecular subtypes: luminal A, luminal B, HER2, and basal. Results: Our analyses identified several genes correlated in all subtypes such as KIAA1967 and MCPH1. In addition, several subtype-specific genes that showed a significant correlation between copy number and gene expression profiles were detected: SMARCB1, AZIN1, MTDH in luminal A, PPP2R5E, APEX1, GCN5 in luminal B, TNFAIP1, PCYT2, DIABLO in HER2, and FAM175B, SENP5, SCAF1 in basal subtype. Conclusions: This study showed that computational analyses integrating copy number and gene expression can contribute to unveil the molecular mechanisms of cancer and identify new subtype-specific biomarkers.

scholarly journals Gene expression profiles of CMS2-epithelial/canonical colorectal cancers are largely driven by DNA copy number gains

Oncogene ◽  
2019 ◽  
Vol 38 (33) ◽  
pp. 6109-6122 ◽  
Author(s):  
Kaja C. G. Berg ◽  
Anita Sveen ◽  
Maren Høland ◽  
Sharmini Alagaratnam ◽  
Marianne Berg ◽  
...  
Keyword(s):  
Gene Expression ◽  
Copy Number ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Colorectal Cancers ◽  
Dna Copy Number

Gene expression profiles in premenopausal women with HR+ HER2− early breast cancer

2020 ◽  
Vol 138 ◽  
pp. S76
Author(s):  
H. Ni ◽  
A. Kurt ◽  
J. Kumbrink ◽  
A. Seiler ◽  
D. Mayr ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Early Breast Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Premenopausal Women
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