S-phase kinase-associated protein 2 expression in laryngeal squamous cell carcinomas and its prognostic implications

2003 ◽  
Author(s):  
Youyi Dong ◽  
Li Sui ◽  
Yasuo Watanabe ◽  
Katsuyoshi Sugimoto ◽  
Masaaki Tokuda
Keyword(s):  
Squamous Cell ◽  
S Phase ◽  
Squamous Cell Carcinomas ◽  
Prognostic Implications

Cytosolic Levels of Neuron-Specific Enolase in Squamous Cell Carcinomas of the Lung

2003 ◽  
Vol 18 (3) ◽  
pp. 188-194 ◽  
Author(s):  
A. Ruibal ◽  
M.I. Nuñez ◽  
J. Rodríguez ◽  
L. Jiménez ◽  
M.C. Del Rio ◽  
...  
Keyword(s):  
Squamous Cell ◽  
Histological Grade ◽  
Clinical Stage ◽  
Neuron Specific Enolase ◽  
S Phase ◽  
Squamous Cell Carcinomas ◽  
Tissue Type ◽  
Ca 125 ◽  
Pulmonary Tissue ◽  
Cell Lung Carcinoma

To study the behavior and possible correlations of neuron-specific enolase (NSE) with other clinicobiological parameters, we measured the cytosolic levels of this marker by means of an immunoradiometric assay (IRMA) in 95 squamous cell lung carcinoma samples. We also analyzed the levels of pS2, tissue-type plasminogen activator (t-PA), hyaluronic acid (HA), free beta subunit of human chorionic gonadotropin (β-HCG), CYFRA 21.1 and CA 125 in cytosol. On the cell surface we analyzed the concentrations of epidermal growth factor receptor (EGFR), HA, erbB-2 oncoprotein, CD44s, CD44v5 and CD44v6. Other parameters considered were clinical stage, lymph node involvement, histological grade (HG), ploidy and the cellular S-phase fraction measured by flow cytometry on nuclei obtained from fresh tissues. In the 95 squamous cell carcinomas the cytosolic levels of NSE varied from 4.5 to 2235 ng/mg protein (median: 267) and were significantly higher (p<0.001) than those observed in 38 samples of normal pulmonary tissue obtained from the same patients (range: 56–657; median: 141.5). When classifying tumors according to the different parameters analyzed, we observed that the levels of NSE were higher in aneuploid than in diploid cases (p=0.046) and in those that were HG3 than in those that were HG2 (p<0.001). Tumors with high NSE levels (>422 ng/mg protein; 75th percentile) were more likely to have high S-phase values (p=0.012) and were more frequently aneuploid (p=0.038) and HG3 (p<0.001) than those with low levels of NSE (<180 ng/mg protein; 25th percentile). These results lead us to the following conclusions: 1) the cytosolic concentrations of NSE are significantly higher in squamous cell carcinomas than in healthy pulmonary tissue, and 2) the cytosolic concentrations of NSE are not correlated with clinical stage or nodal involvement. However, in our study higher levels of the enzyme were statistically correlated with aneuploidy, histological grade 3 and S-phase. This may explain its association with poorer outcome and progression, but also the more favorable response of tumors with elevated NSE to chemotherapy, as suggested by other groups.

High Rates of Ultraviolet-Signature Mutations in Squamous Cell Carcinomas of the Parotid Gland and Prognostic Implications

2021 ◽  
Author(s):  
Shira Fishbach ◽  
George Steinhardt ◽  
Chao Jie Zhen ◽  
Rutika Puranik ◽  
Jeremy P. Segal ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Prognostic Implications

scholarly journals Prognostic implications of human papillomavirus status for patients with non-oropharyngeal head and neck squamous cell carcinomas

2017 ◽  
Vol 143 (11) ◽  
pp. 2341-2350 ◽  
Author(s):  
Huaising C. Ko ◽  
Paul M. Harari ◽  
Ryan M. Sacotte ◽  
Shuai Chen ◽  
Aaron M. Wieland ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Head And Neck ◽  
Squamous Cell ◽  
Squamous Cell Carcinomas ◽  
Prognostic Implications

Cell Kinetics of Head and Neck Squamous Cell Carcinomas: Prognostic implications

1994 ◽  
Vol 33 (1) ◽  
pp. 23-28 ◽  
Author(s):  
Karin Nylander ◽  
Göran Anneroth ◽  
Hans Gustafsson ◽  
Göran Roos ◽  
Roger Stenling ◽  
...  
Keyword(s):  
Head And Neck ◽  
Squamous Cell ◽  
Cell Kinetics ◽  
Squamous Cell Carcinomas ◽  
Prognostic Implications ◽  
Kinetics Of

Ultrastructural features of prognostic significance in human oral cancer

1992 ◽  
Vol 50 (1) ◽  
pp. 618-619
Author(s):  
Karvita B. Ahluwalia ◽  
Nidhi Sharma
Keyword(s):  
Oral Cancer ◽  
Squamous Cell ◽  
Common Knowledge ◽  
Prognostic Significance ◽  
Growth Control ◽  
Terminal Differentiation ◽  
Squamous Cell Carcinomas ◽  
Effective Therapy ◽  
Invasive Potential ◽  
Biological Behaviour

It is common knowledge that apparently similar tumors often show different responses to therapy. This experience has generated the idea that histologically similar tumors could have biologically distinct behaviour. The development of effective therapy therefore, has the explicit challenge of understanding biological behaviour of a tumor. The question is which parameters in a tumor could relate to its biological behaviour ? It is now recognised that the development of malignancy requires an alteration in the program of terminal differentiation in addition to aberrant growth control. In this study therefore, ultrastructural markers that relate to defective terminal differentiation and possibly invasive potential of cells have been identified in human oral leukoplakias, erythroleukoplakias and squamous cell carcinomas of the tongue.

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