scholarly journals Secretagogin, a marker for neuroendocrine cells, is more sensitive and specific in large cell neuroendocrine carcinoma compared with the markers CD56, CgA, Syn and Napsin A

2020 ◽  
Author(s):  
Yunlong Dong ◽  
Yongwen Li ◽  
Renwang Liu ◽  
Ying Li ◽  
Hongbing Zhang ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Neuroendocrine Cells ◽  
Napsin A

scholarly journals Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations

2017 ◽  
Vol 31 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Natasha Rekhtman ◽  
Catherine M Pietanza ◽  
Joshua Sabari ◽  
Joseph Montecalvo ◽  
Hangjun Wang ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Genomic Alterations ◽  
Napsin A

scholarly journals A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Neema Hooker ◽  
Sveta Mohanan ◽  
R. Tucker Burks
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Uterine Cervix ◽  
Female Genital Tract ◽  
Stage Iv ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Neuroendocrine Cells ◽  
Caucasian Woman ◽  
Body Tissues ◽  
The Right

Neuroendocrine tumors (NETs) are aggressive diseases developing from neuroendocrine cells that most frequently involve the gastro-entero-pancreatic tract and the lung, but more rarely are found in almost all body tissues. Limited biological and clinical data are currently available for NETs in uncommon sites, such as female genital tract. NETs represent 0.9% to 1.5% of the tumors of the uterine cervix. This case is reported on a 75-year-old Caucasian woman, presenting with dental and generalized pain for two weeks. Later during her admission, facial droop and diplopia were noticed. Radiological findings ruled out cerebrovascular accident but revealed multiple bone marrow lesions involving the left and the right clivus, right Meckel's cave, and posterior margin of the right cavernous sinus. Findings also included pulmonary nodules and adenopathy supporting diagnosis of likely stage IV metastatic carcinoma. Further imaging revealed homogeneous enhancement of the uterus suggestive of diffusely infiltrative carcinoma; pathology results confirmed large cell neuroendocrine carcinoma of the uterine cervix (LCNEC) giving her a 1.5-month median survival range.

scholarly journals A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma

2019 ◽  
Vol 153 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Marina K Baine ◽  
John H Sinard ◽  
Guoping Cai ◽  
Robert J Homer
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Large Cell ◽  
Tissue Microarrays ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Cutoff Score ◽  
Ki 67 ◽  
Cell Lung Carcinoma ◽  
Biopsy Diagnosis ◽  
Napsin A

Abstract Objectives The aim of this study was to devise reproducible biopsy criteria for distinguishing pulmonary large cell neuroendocrine carcinoma (LCNEC) from non-small cell lung carcinoma (NSCLC). Methods Tissue microarrays of LCNEC and NSCLC were generated from resection specimens and used as biopsy surrogates. They were stained for neuroendocrine markers, Ki-67, napsin-A, and p40, and independently analyzed by standardized morphologic criteria by four pathologists. Tumors were scored based on morphology, neuroendocrine marker expression, and Ki-67 proliferative index. Results The average total score for LCNEC was significantly higher than for NSCLC (5.65 vs 0.51, P < .0001). Utilizing a cutoff score of 4 or higher showed 100% sensitivity and 99% specificity for LCNEC diagnosis, with an excellent agreement among four pathologists (98%). Conclusions The proposed semiquantitative approach based on a combination of specific morphologic and immunophenotypic features may be a useful tool for biopsy diagnosis of LCNEC.

Sign in / Sign up

Export Citation Format

Share Document