scholarly journals Pulmonary large cell neuroendocrine carcinoma with adenocarcinoma-like features: napsin A expression and genomic alterations

2017 ◽  
Vol 31 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Natasha Rekhtman ◽  
Catherine M Pietanza ◽  
Joshua Sabari ◽  
Joseph Montecalvo ◽  
Hangjun Wang ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Genomic Alterations ◽  
Napsin A

scholarly journals A Semiquantitative Scoring System May Allow Biopsy Diagnosis of Pulmonary Large Cell Neuroendocrine Carcinoma

2019 ◽  
Vol 153 (2) ◽  
pp. 165-174 ◽  
Author(s):  
Marina K Baine ◽  
John H Sinard ◽  
Guoping Cai ◽  
Robert J Homer
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Large Cell ◽  
Tissue Microarrays ◽  
Large Cell Neuroendocrine Carcinoma ◽  
Cutoff Score ◽  
Ki 67 ◽  
Cell Lung Carcinoma ◽  
Biopsy Diagnosis ◽  
Napsin A

Abstract Objectives The aim of this study was to devise reproducible biopsy criteria for distinguishing pulmonary large cell neuroendocrine carcinoma (LCNEC) from non-small cell lung carcinoma (NSCLC). Methods Tissue microarrays of LCNEC and NSCLC were generated from resection specimens and used as biopsy surrogates. They were stained for neuroendocrine markers, Ki-67, napsin-A, and p40, and independently analyzed by standardized morphologic criteria by four pathologists. Tumors were scored based on morphology, neuroendocrine marker expression, and Ki-67 proliferative index. Results The average total score for LCNEC was significantly higher than for NSCLC (5.65 vs 0.51, P < .0001). Utilizing a cutoff score of 4 or higher showed 100% sensitivity and 99% specificity for LCNEC diagnosis, with an excellent agreement among four pathologists (98%). Conclusions The proposed semiquantitative approach based on a combination of specific morphologic and immunophenotypic features may be a useful tool for biopsy diagnosis of LCNEC.

Large-cell neuroendocrine carcinoma without immunohistological positivity or serum elevation of CEA until relapse

2008 ◽  
Vol 56 (11) ◽  
pp. 547-550
Author(s):  
Yasutaka Watanabe ◽  
Shunsuke Endo ◽  
Hiroyoshi Tsubochi ◽  
Mitsuhiro Nokubi ◽  
Shinichiro Koyama ◽  
...  
Keyword(s):  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Large Cell Neuroendocrine Carcinoma
Sign in / Sign up

Export Citation Format

Share Document