scholarly journals Correlation of ERK/MAPK signaling pathway with proliferation and apoptosis of colon cancer cells

2018 ◽  
Author(s):  
Gang Zhou ◽  
Jing Yang ◽  
Peng Song
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Colon Cancer Cells ◽  
Erk Mapk ◽  
Proliferation And Apoptosis

Targeting of super-enhancers and mutant BRAF can suppress growth of BRAF -mutant colon cancer cells via repression of MAPK signaling pathway

2017 ◽  
Vol 402 ◽  
pp. 100-109 ◽  
Author(s):  
Yoshiaki Nakamura ◽  
Naoko Hattori ◽  
Naoko Iida ◽  
Satoshi Yamashita ◽  
Akiko Mori ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Colon Cancer Cells ◽  
Braf Mutant ◽  
Mutant Braf

scholarly journals Calreticulin promotes EGF-induced EMT in pancreatic cancer cells via Integrin/EGFR-ERK/MAPK signaling pathway

2017 ◽  
Vol 8 (10) ◽  
pp. e3147-e3147 ◽  
Author(s):  
Weiwei Sheng ◽  
Chuanping Chen ◽  
Ming Dong ◽  
Guosen Wang ◽  
Jianping Zhou ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Erk Mapk ◽  
Pancreatic Cancer Cells

scholarly journals Pramanicin Analog Induces Apoptosis in Human Colon Cancer Cells: Critical Roles for Bcl-2, Bim, and p38 MAPK Signaling

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e56369 ◽  
Author(s):  
Cagri Bodur ◽  
Ozgur Kutuk ◽  
Gizem Karsli-Uzunbas ◽  
Tayirjan T. Isimjan ◽  
Paul Harrison ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
P38 Mapk ◽  
Human Colon ◽  
Mapk Signaling ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Human Colon Cancer Cells

scholarly journals ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells

2021 ◽  
Vol 12 (4) ◽  
Author(s):  
Yong Ji ◽  
Yiqian Liu ◽  
Changchun Sun ◽  
Lijiang Yu ◽  
Zhao Wang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Colony Formation ◽  
Activation Mechanism ◽  
Colon Cancer Cells ◽  
Mechanistic Studies ◽  
T Cell Factor ◽  
And Migration

AbstractAs a result of mutations in the upstream components of the Wnt/β-catenin signaling pathway, this cascade is abnormally activated in colon cancer. Hence, identifying the activation mechanism of this pathway is an urgent need for the treatment of colon cancer. Here, we found an increase in ADCK1 (AarF domain-containing kinase 1) expression in clinical specimens of colon cancer and animal models. Upregulation of ADCK1 expression promoted the colony formation and infiltration of cancer cells. Downregulation of ADCK1 expression inhibited the colony formation and infiltration of cancer cells, in vivo tumorigenesis, migration, and organoid formation. Molecular mechanistic studies demonstrated that ADCK1 interacted with TCF4 (T-cell factor 4) to activate the β-catenin/TCF signaling pathway. In conclusion, our research revealed the functions of ADCK1 in the development of colon cancer and provided potential therapeutic targets.

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