scholarly journals mir‑106a regulates cell proliferation and apoptosis of colon cancer cells through targeting the PTEN/PI3K/AKT signaling pathway

2017 ◽  
Author(s):  
Yan Qin ◽  
Zhibin Huo ◽  
Xiang Song ◽  
Xiao Chen ◽  
Xiaopeng Tian ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Colon Cancer Cells ◽  
Akt Signaling Pathway ◽  
Proliferation And Apoptosis

scholarly journals Angiomotin promotes the malignant potential of colon cancer cells by activating the YAP-ERK/PI3K-AKT signaling pathway

2016 ◽  
Vol 36 (6) ◽  
pp. 3619-3626 ◽  
Author(s):  
Yan Zhang ◽  
Jun Yuan ◽  
Xinli Zhang ◽  
Futang Yan ◽  
Minggang Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Malignant Potential ◽  
Colon Cancer Cells ◽  
Akt Signaling Pathway

scholarly journals siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway

2019 ◽  
Vol Volume 11 ◽  
pp. 5799-5811 ◽  
Author(s):  
Yini Ma ◽  
Liying Guan ◽  
Yanxin Han ◽  
Yi Zhou ◽  
Xiaoming Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Colon Cancer Cells ◽  
Akt Signaling Pathway ◽  
Proliferation And Metastasis

scholarly journals Knockdown of PRDX2 sensitizes colon cancer cells to 5-FU by suppressing the PI3K/AKT signaling pathway

2017 ◽  
Vol 37 (3) ◽  
Author(s):  
Jun Xu ◽  
Shouru Zhang ◽  
Rong Wang ◽  
Xingye Wu ◽  
Li Zeng ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Protein Expression ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Cancer Resistance ◽  
Colon Cancer Cells ◽  
Akt Signaling Pathway ◽  
Ros Scavenging ◽  
Bax Protein

Although, 5-Fluorouracil (5-FU) remains widely used in adjuvant therapy in patients with colon cancer, resistance to 5-FU-based chemotherapy is an important reason for treatment failure. Recent studies have reported that an enhanced reactive oxygen species (ROS) scavenging system shows drug resistance to 5-FU. Peroxiredoxin-2 (PRDX2), is an important member of the ROS scavenging system, and may be a potential target that promotes chemosensitivity to 5-FU in colon cancer. Here, we depleted PRDX2 by PRDX2-shRNA-LV transduction in two colon cancer cell lines and found that in vitro PRDX2 knockdown facilitates cell death, and apoptosis in 5-FU-treated colon cancer cells. In addition, we found that PRDX2 depletion in mice treated with 5-FU resulted in, inhibition of tumor growth, compared with mice treated with 5-FU alone. Our data also suggested that the PI3K/AKT signaling pathway links PRDX2 with 5-FU-induced apoptosis in colon cancer. Furthermore, when PRDX2 was overexpressed in colon cancer cells, we found increased p-AKT protein expression and reduced Bcl-2/Bax protein expression. PRDX2 and p-AKT protein expression were analyzed by immunohistochemistry technology in human colon carcinoma tissues. Pearson correlation coefficient is 0.873 and P<0.05. PRDX2 depletion led to reduced p-AKT expression and PI3K/AKT pathway inhibition promoted cell apoptosis in HT29 cell line. Taken together, our study suggests that decreasing the expression of PRDX2 could be a promising strategy for increasing the sensitivity of colon cancer cells to 5-FU.

scholarly journals MACC1 facilitates chemoresistance and cancer stem cell-like properties of colon cancer cells through the PI3K/AKT signaling pathway

2017 ◽  
Vol 16 (6) ◽  
pp. 8747-8754 ◽  
Author(s):  
Jiankai Wang ◽  
Wenjuan Wang ◽  
Hongyi Cai ◽  
Binbin Du ◽  
Lijuan Zhang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Stem Cell ◽  
Cancer Stem Cell ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Colon Cancer Cells ◽  
Akt Signaling Pathway
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