scholarly journals Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage

2018 ◽  
Author(s):  
Yifeng He ◽  
Yu Zhou ◽  
Ji Zhang ◽  
Fei Yuan ◽  
Jun Wang ◽  
...  
2017 ◽  
Vol 13 (6) ◽  
pp. 4459-4462 ◽  
Author(s):  
Chao Wang ◽  
Rui-Rui Song ◽  
Ping-Ding Kuang ◽  
Liu-Hong Wang ◽  
Min-Ming Zhang

1987 ◽  
Vol 16 (8) ◽  
pp. 635-643 ◽  
Author(s):  
Steven D. Herman ◽  
Mamed Mesgarzadeh ◽  
Akbar Bonakdarpour ◽  
Murray K. Dalinka

2011 ◽  
Vol 101 (2) ◽  
pp. 187-189 ◽  
Author(s):  
Jeff Findling ◽  
Natalie K. LaScola ◽  
Thomas W. Groner

Giant cell tumor of tendon sheath is infrequently documented in the foot and even less near the ankle. This case report involves such a tumor of the flexor hallucis longus tendon presenting at the posterior ankle. Diagnosis was aided by magnetic resonance imaging, and treatment consisted of complete surgical excision. Pathologic examination verified the diagnosis of giant cell tumor of tendon sheath, and follow-up magnetic resonance imaging revealed no remnants or recurrence of tumor 1 year after surgery. (J Am Podiatr Med Assoc 101(2): 187–189, 2011)


2017 ◽  
Vol 107 (4) ◽  
pp. 333-336 ◽  
Author(s):  
Michael Levi ◽  
Jordan Crafton

Giant-cell tumor of the tendon sheath (GCT-TS) is an uncommon occurrence for a foot and ankle surgeon. However, there is a need to recognize the symptoms of typical and atypical presentations of this pathology. These benign neoplasms are recognized clinically as a soft-tissue mass that is usually painless and palpable. The foot and ankle account for only 3% to 5% of all GCT-TS in the body, with most being located in the hand. Giant cell tumor in the tendon sheath occurring in the foot and ankle is usually encountered on the lateral ankle and dorsum of the foot, occupying the extensor tendons. Additionally, it is commonly misdiagnosed clinically. This case study illustrates how early use of magnetic resonance imaging decreased patient morbidity with early recognition and excision of GCT-TS.


2019 ◽  
Author(s):  
Lina Zhang ◽  
Jianyun Kang ◽  
Kai Zhang ◽  
Ailian Liu ◽  
Huali Wang ◽  
...  

Abstract Background Primary soft tissue giant cell tumor (GCT-ST) is a rare tumor with low malignant potential. Here we reported two cases of patients with soft tissue giant cell tumor in the limb, including their clinical and imaging findings (conventional Magnetic resonance imaging (MRI) and Diffusion weighted imaging (DWI)).Methods This retrospective study included two pathology-confirmed GCT-ST patients. Plain MRI, dynamic contrast enhancement MRI (DCE-MRI), and DWI were performed with a 3.0T whole-body MR scanner before surgery. The following characteristics of lesion were recorded: signal intensity on T 1 FSPGR and T 2 WI, morphology, maximum lesion size, time intensity curve (TIC) on DCE-MRI, and apparent diffusion coefficient (ADC) value from DWI.Results The maximum lesion size ranged from 4.0 cm to 6.0 cm. Signal intensities of all lesions were heterogeneous on T 1 FSPGR and T 2 WI. Nodular enhancements were observed for all lesions with either oval or irregular shapes on MRI. All lesion margins were blurred, and internal enhancements were heterogeneous on DCE-MRI. TIC appeared with a slow increase type. Lesions on DWI (b=500s/mm 2 ) were hyperintense with an higher mean ADC value of 2.19×10 −3 mm 2 /s compared to surrounding normal soft tissue (1.03×10 −3 mm 2 /s).Conclusions DWI may be a useful tool for differentiating benign soft tissue mass from giant cell-rich soft tissue neoplasms or malignant tumors.


2020 ◽  
pp. 028418512097691
Author(s):  
Makoto Emori ◽  
Hiroyuki Takashima ◽  
Kousuke Iba ◽  
Tomoko Sonoda ◽  
Takashi Oda ◽  
...  

Background The differential diagnosis of fibroma of tendon sheath (FTS) and giant cell tumor of tendon sheath (GCTTS) on the basis of clinical and radiographic characteristics remains difficult. Purpose To evaluate the quantitative measurement of signal intensity (SI) obtained by magnetic resonance imaging (MRI) for the differential diagnosis of FTS and GCTTS in just the finger. Material and Methods We retrospectively identified patients with FTS (n = 6) and GCTTS (n = 22) of the finger who were treated at our hospitals between April 2011 and August 2019. Two researchers independently reviewed the MRIs and measured the regions of interest (ROIs) in the tumor and flexor tendon from the same image. The SI ratio obtained for the tumor and tendon ROIs was measured and compared using receiver-operating characteristic curve analyses. Sensitivity and specificity analyses were performed. Results The SI ratios (mean ± SD) of FTS and GCTTS were 1.83 ± 0.64 and 6.34 ± 3.16 for researcher 1 and 1.82 ± 0.60 and 6.10 ± 3.22 for researcher 2, respectively. The areas under the curve were 0.970 and 0.970 for researchers 1 and 2, respectively. The cut-off values of the SI ratio as determined by researchers 1 and 2 for differentiating FTS from GCTTS were 3.00 and 3.00, respectively (sensitivity = 95.5%, specificity = 100%). Conclusions The SI ratio is useful for differentiating FTS from GCTTS independent of a combination of tumor signal and shape.


2017 ◽  
Vol 46 (2) ◽  
pp. 710-722
Author(s):  
Yifeng He ◽  
Jun Wang ◽  
Ji Zhang ◽  
Lianjun Du ◽  
Yong Lu ◽  
...  

Objective To identify the prognostic factors for local recurrence of giant cell tumor of bone (GCTB) through assessment of the preoperative imaging features of the tumor border. Methods Patients with GCTBs treated with intralesional procedures in the proximal tibia and distal femur were prospectively enrolled and then followed up for at least 2 years. The GCTBs were grouped according to their preoperative imaging features. GCTBs treated with en bloc resection were enrolled for investigation of the pathologic basis of specific imaging features. Differences between rates were evaluated by the chi-square test or Fisher’s exact test; independent factors were identified by multivariate logistic regression analysis. Results Fifty-three patients were enrolled and successfully followed up. Relapse occurred in 22 patients. Patients with a “paintbrush borders” sign (n = 21) had a significantly higher rate of local recurrence (71.43%) than patients without this sign (21.88%). The “paintbrush borders” sign was identified as an independent prognostic factor for local recurrence. Other imaging features were not significantly associated with recurrence. The “paintbrush borders” sign showed a correlation with local invasion of bone. Conclusion The “paintbrush borders” sign on preoperative magnetic resonance imaging is an independent prognostic factor for local recurrence of GCTB.


2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Michele Gaeta ◽  
Giuseppe Cicero ◽  
Luca Fiorillo ◽  
Sergio Vinci ◽  
Alfredo Blandino ◽  
...  

Giant cell tumor of the tendon sheath is a tumor, which affects mainly the hands of people aged 30 to 50 years with a female prevalence. Magnetic resonance imaging (MRI) is essential for diagnosis and treatment planning. The aim of this study is to evaluate the efficacy of multiecho gradient-echoes (MeGE) sequence in detecting hemosiderin which is the hallmark of this tumor. MRIs were performed in a sample of 11 patients with a mean age of 45. With the proposed protocol, all readers were able to detect the susceptibility artifacts due to the presence of hemosiderin. MeGE sequence allows to highlight the presence of hemosiderin, and the use of 3 echo times (ET) (8, 16, and 24 ms) is suggested.


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