scholarly journals Betulinic acid exerts potent antitumor effects on paclitaxel‑resistant human lung carcinoma cells (H460) via G2/M phase cell cycle arrest and induction of mitochondrial apoptosis

2018 ◽  
Author(s):  
Xiao‑Kai Zhan ◽  
Jun‑Ling Li ◽  
Sen Zhang ◽  
Pu‑Yuan Xing ◽  
Meng‑Fan Xia
Keyword(s):  
Cell Cycle ◽  
Human Lung ◽  
Carcinoma Cells ◽  
Phase Cell ◽  
Mitochondrial Apoptosis ◽  
Antitumor Effects ◽  
Lung Carcinoma Cells ◽  
Cycle Arrest ◽  
M Phase ◽  
Human Lung Carcinoma

Induction of Cell Cycle Arrest and Apoptosis by Ruthenium Complex cis-(Dichloro)tetramineruthenium(III) Chloride in Human Lung Carcinoma Cells A549

2011 ◽  
Vol 147 (1-3) ◽  
pp. 8-15 ◽  
Author(s):  
Aliny Pereira de Lima ◽  
Flávia de Castro Pereira ◽  
Cesar Augusto Sam Tiago Vilanova-Costa ◽  
Jordana Ribeiro Soares ◽  
Lucas Carlos Gomes Pereira ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Lung Carcinoma ◽  
Human Lung ◽  
Ruthenium Complex ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Cycle Arrest ◽  
Human Lung Carcinoma

scholarly journals Serum deprivation enhanced ethanol-induced toxic responses in A549, lung carcinoma cells

2022 ◽  
Vol 43 (1) ◽  
pp. 26-34
Author(s):  
P. Khare ◽  
◽  
V.K. Singh ◽  
L. Bala ◽  
◽  
...  
Keyword(s):  
Cell Cycle ◽  
Lung Carcinoma ◽  
Human Lung ◽  
Ethanol Concentration ◽  
Carcinoma Cells ◽  
Complete Medium ◽  
Lung Carcinoma Cells ◽  
Cycle Arrest ◽  
Human Lung Carcinoma ◽  
A549 Lung

Aim: The current study explores the toxic consequences of ethanol on human lung carcinoma cell, A549 in serum-deprived condition. Methodology: Human lung carcinoma cells, A549, were cultured in complete and serum-deprived medium for 6 hr. Subsequently, they were exposed to 50 mM and 100 mM concentrations of ethanol. Cytotoxicity studies linked with cell viability, oxidative stress, cell cycle arrest and micronuclei formation were performed using various toxicological parameters, namely MTT assay, DCFDA based ROS generation, cell cycle analysis and micronuclei formation assay. The cytotoxicity of ethanol in complete and serum deprived medium were compared at similar doses and time duration. Results: The metabolic viability assay demonstrated that 50 mM and 100 mM concentration of ethanol did not induce significant levels of cytotoxic alteration in A549 lung carcinoma cells in complete medium. However, in serum-deprived conditions, 50 mM and 100 mM ethanol concentration significantly altered cell viability. Further, exposure of 50 mM and 100 mM concentration of ethanol enhanced reactive oxygen species levels in A549 cells more significantly in serum-deprived conditions than in complete medium. In addition to cytotoxicity and oxidative stress, 50 mM and 100 mM ethanol also arrested the cells at G0 phase more significantly in serum deprived conditions compared to complete medium. Interpretation: Both 50 mM and 100 mM ethanol concentration enhanced the cell cytotoxicity and reactive oxygen species, cell cycle arrest and micronuclei formation more severely in serum-deprived medium than in complete medium (containing 10% FBS) under similar treatment conditions.

Involvement of the role of Chk1 in lithium‐induced G2/M phase cell cycle arrest in hepatocellular carcinoma cells

2008 ◽  
Vol 104 (4) ◽  
pp. 1181-1191 ◽  
Author(s):  
Xiao‐Ming Wang ◽  
Jiao Li ◽  
Xiao‐Cheng Feng ◽  
Qiong Wang ◽  
Dong‐Yin Guan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Cycle ◽  
Cell Cycle Arrest ◽  
Carcinoma Cells ◽  
Phase Cell ◽  
Hepatocellular Carcinoma Cells ◽  
Cycle Arrest ◽  
M Phase
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