scholarly journals Clinical significance of chromodomain helicase/ATPase DNA binding protein 1‑like and human mutL homolog�1 gene expression in cholangiocarcinoma

2018 ◽  
Author(s):  
Jingwen Hua ◽  
Shiniao Li ◽  
Changwen Huang
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Clinical Significance ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Mutl Homolog 1

scholarly journals A novel DNA-binding protein regulates sexual differentiation in malaria parasites and is essential for transmission

2020 ◽  
Author(s):  
Riward Campelo Morillo ◽  
Xinran Tong ◽  
Wei Xie ◽  
Todd Lenz ◽  
Gayani Batugedara ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Sexual Differentiation ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Homeodomain Protein ◽  
Mosquito Vector ◽  
Malaria Parasites ◽  
Membrane Complex ◽  
Inner Membrane Complex

ABSTRACTTransmission of Plasmodium falciparum and other malaria parasites requires their differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage necessary for transmission to the mosquito vector. This transition involves changes in gene expression and chromatin reorganization mediating the silencing and activation of stage-specific genes. However, malaria parasites have been noted for their dearth of transcriptional and chromatin regulators and the molecular mediators of these changes remain largely unknown. We identified Homeodomain protein 1 (HDP1) as a novel chromatin-associated DNA-binding protein that drives changes in chromatin structure and gene expression during early sexual differentiation. This discovery of a homeodomain-like DNA-binding protein marks a new class of transcriptional regulator in malaria parasites outside of the better-characterized ApiAP2 family. In this study, we demonstrate that HDP1 is required for gametocyte maturation and parasite transmission by driving the necessary upregulation of inner membrane complex components in early gametocytes.

scholarly journals Gene D5 product of bacteriophage T5: DNA-binding protein affecting DNA replication and late gene expression.

1979 ◽  
Vol 29 (1) ◽  
pp. 322-327 ◽  
Author(s):  
D J McCorquodale ◽  
J Gossling ◽  
R Benzinger ◽  
R Chesney ◽  
L Lawhorne ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Replication ◽  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Late Gene ◽  
Late Gene Expression ◽  
Bacteriophage T5

Involvement of a DNA Binding Protein, MDR-NF1/YB-1, in Human MDR1 Gene Expression by Actinomycin D

1994 ◽  
Vol 199 (3) ◽  
pp. 1428-1435 ◽  
Author(s):  
K. Asakuno ◽  
K. Kohno ◽  
T. Uchiumi ◽  
T. Kubo ◽  
S. Sato ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Actinomycin D ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Mdr1 Gene ◽  
Mdr1 Gene Expression ◽  
Human Mdr1

scholarly journals Gene expression profile of DNA binding protein A transgenic mice

2006 ◽  
Author(s):  
Hiroshi Tobita ◽  
Kazunori Kajino ◽  
Kouichi Inami ◽  
Sayaka Kano ◽  
Mahmut Yasen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Transgenic Mice ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Binding Protein ◽  
Protein A ◽  
Dna Binding Protein
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