scholarly journals Gene expression profile of DNA binding protein A transgenic mice

2006 ◽  
Author(s):  
Hiroshi Tobita ◽  
Kazunori Kajino ◽  
Kouichi Inami ◽  
Sayaka Kano ◽  
Mahmut Yasen ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Transgenic Mice ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Binding Protein ◽  
Protein A ◽  
Dna Binding Protein

scholarly journals A novel DNA-binding protein regulates sexual differentiation in malaria parasites and is essential for transmission

2020 ◽  
Author(s):  
Riward Campelo Morillo ◽  
Xinran Tong ◽  
Wei Xie ◽  
Todd Lenz ◽  
Gayani Batugedara ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Binding ◽  
Sexual Differentiation ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Homeodomain Protein ◽  
Mosquito Vector ◽  
Malaria Parasites ◽  
Membrane Complex ◽  
Inner Membrane Complex

ABSTRACTTransmission of Plasmodium falciparum and other malaria parasites requires their differentiation from asexual blood stages into gametocytes, the non-replicative sexual stage necessary for transmission to the mosquito vector. This transition involves changes in gene expression and chromatin reorganization mediating the silencing and activation of stage-specific genes. However, malaria parasites have been noted for their dearth of transcriptional and chromatin regulators and the molecular mediators of these changes remain largely unknown. We identified Homeodomain protein 1 (HDP1) as a novel chromatin-associated DNA-binding protein that drives changes in chromatin structure and gene expression during early sexual differentiation. This discovery of a homeodomain-like DNA-binding protein marks a new class of transcriptional regulator in malaria parasites outside of the better-characterized ApiAP2 family. In this study, we demonstrate that HDP1 is required for gametocyte maturation and parasite transmission by driving the necessary upregulation of inner membrane complex components in early gametocytes.

scholarly journals Gene D5 product of bacteriophage T5: DNA-binding protein affecting DNA replication and late gene expression.

1979 ◽  
Vol 29 (1) ◽  
pp. 322-327 ◽  
Author(s):  
D J McCorquodale ◽  
J Gossling ◽  
R Benzinger ◽  
R Chesney ◽  
L Lawhorne ◽  
...  
Keyword(s):  
Gene Expression ◽  
Dna Replication ◽  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Late Gene ◽  
Late Gene Expression ◽  
Bacteriophage T5

scholarly journals Gene Expression Profile in Thyroid of Transgenic Mice Overexpressing the Adenosine Receptor 2a

2004 ◽  
Vol 18 (1) ◽  
pp. 194-213 ◽  
Author(s):  
Jean-Christophe Goffard ◽  
Ling Jin ◽  
Hortensia Mircescu ◽  
Paul Van Hummelen ◽  
Catherine Ledent ◽  
...  
Keyword(s):  
Gene Expression ◽  
Transgenic Mice ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Adenosine Receptor

scholarly journals Identity of the 17-kilodalton protein, a DNA-binding protein from Escherichia coli, and the firA gene product.

1988 ◽  
Vol 170 (12) ◽  
pp. 5916-5918 ◽  
Author(s):  
R Aasland ◽  
J Coleman ◽  
A L Holck ◽  
C L Smith ◽  
C R Raetz ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Dna Binding ◽  
Gene Product ◽  
Binding Protein ◽  
Protein A ◽  
Dna Binding Protein

scholarly journals The Up-Regulation of Y-Box Binding Proteins (DNA Binding Protein A and Y-Box Binding Protein-1) as Prognostic Markers of Hepatocellular Carcinoma

2005 ◽  
Vol 11 (20) ◽  
pp. 7354-7361 ◽  
Author(s):  
Mahmut Yasen ◽  
Kazunori Kajino ◽  
Sayaka Kano ◽  
Hiroshi Tobita ◽  
Junji Yamamoto ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Dna Binding ◽  
Binding Proteins ◽  
Prognostic Markers ◽  
Binding Protein ◽  
Protein A ◽  
Dna Binding Protein

scholarly journals Gene Expression Profiling of Leiomyoma and Myometrial Smooth Muscle Cells in Response to Transforming Growth Factor-β

Endocrinology ◽  
2005 ◽  
Vol 146 (3) ◽  
pp. 1097-1118 ◽  
Author(s):  
Xiaoping Luo ◽  
Li Ding ◽  
Jingxia Xu ◽  
Nasser Chegini
Keyword(s):  
Gene Expression ◽  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Binding Protein ◽  
Muscle Cells ◽  
Time Dependent ◽  
Early Gene ◽  
A Cell

Altered expression of the TGF-β system is recognized to play a central role in various fibrotic disorders, including leiomyoma. In this study we performed microarray analysis to characterize the gene expression profile of leiomyoma and matched myometrial smooth muscle cells (LSMC and MSMC, respectively) in response to the time-dependent action of TGF-β and, after pretreatment with TGF-β type II receptor (TGF-βRII) antisense oligomer-blocking/reducing TGF-β autocrine/paracrine actions. Unsupervised and supervised assessments of the gene expression values with a false discovery rate selected at P ≤ 0.001 identified 310 genes as differentially expressed and regulated in LSMC and MSMC in a cell- and time-dependent manner by TGF-β. Pretreatment with TGF-βRII antisense resulted in changes in the expression of many of the 310 genes regulated by TGF-β, with 54 genes displaying a response to TGF-β treatment. Comparative analysis of the gene expression profile in TGF-βRII antisense- and GnRH analog-treated cells indicated that these treatments target the expression of 222 genes in a cell-specific manner. Gene ontology assigned these genes functions as cell cycle regulators, transcription factors, signal transducers, tissue turnover, and apoptosis. We validated the expression and TGF-β time-dependent regulation of IL-11, TGF-β-induced factor, TGF-β-inducible early gene response, early growth response 3, CITED2 (cAMP response element binding protein-binding protein/p300-interacting transactivator with ED-rich tail), Nur77, Runx1, Runx2, p27, p57, growth arrest-specific 1, and G protein-coupled receptor kinase 5 in LSMC and MSMC using real-time PCR. Together, the results provide the first comprehensive assessment of the LSMC and MSMC molecular environment targeted by autocrine/paracrine action of TGF-β, highlighting potential involvement of specific genes whose products may influence the outcome of leiomyoma growth and fibrotic characteristics by regulating inflammatory response, cell growth, apoptosis, and tissue remodeling.

scholarly journals Highly repeated sites in the apolipoprotein(a) gene recognized by methylated DNA-binding protein, a sequence-specific DNA-binding protein.

1990 ◽  
Vol 10 (9) ◽  
pp. 4957-4960 ◽  
Author(s):  
K C Ehrlich ◽  
M Ehrlich
Keyword(s):  
Risk Factor ◽  
Dna Binding ◽  
Binding Protein ◽  
Protein A ◽  
Dna Binding Protein ◽  
High Plasma ◽  
Methylated Dna ◽  
Human Apolipoprotein ◽  
Apolipoprotein A ◽  
Lower Molecular Mass

Methylated DNA-binding protein (MDBP), a sequence-specific DNA-binding protein, was found to recognize more than 30 sites within an allele of the human apolipoprotein(a) gene. High plasma levels of apolipoprotein(a), a risk factor for atherosclerosis, have been correlated with genetically inherited lower-molecular-mass isoforms of this protein. MDBP might help down modulate the expression of the apolipoprotein(a) gene in a manner dependent on the length of a given allele of the gene and the number of MDBP sites in it.

scholarly journals The Bacteriophage T4 MotB Protein, a DNA-Binding Protein, Improves Phage Fitness

Viruses ◽  
2018 ◽  
Vol 10 (7) ◽  
pp. 343 ◽  
Author(s):  
Jennifer Patterson-West ◽  
Melissa Arroyo-Mendoza ◽  
Meng-Lun Hsieh ◽  
Danielle Harrison ◽  
Morgan Walker ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Bacteriophage T4 ◽  
Protein A ◽  
Dna Binding Protein
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