scholarly journals Identification of common differentially‑expressed miRNAs in ovarian cancer cells and their exosomes compared with normal ovarian surface epithelial cell cells

2018 ◽  
Author(s):  
Shitao Zhang ◽  
Xiaoping Zhang ◽  
Xueqi Fu ◽  
Wannan Li ◽  
Shu Xing ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Cell ◽  
Cancer Cells ◽  
Differentially Expressed ◽  
Ovarian Cancer Cells ◽  
Surface Epithelial Cell ◽  
Ovarian Surface Epithelial Cell ◽  
Ovarian Surface ◽  
Differentially Expressed Mirnas ◽  
Ovarian Surface Epithelial

DAXX silencing suppresses mouse ovarian surface epithelial cell growth by inducing senescence and DNA damage

Gene ◽  
2013 ◽  
Vol 526 (2) ◽  
pp. 287-294 ◽  
Author(s):  
Wei-Wei Pan ◽  
Fa-Ping Yi ◽  
Li-Xian Cao ◽  
Xiao-Man Liu ◽  
Zhong-Fei Shen ◽  
...  
Keyword(s):  
Dna Damage ◽  
Cell Growth ◽  
Epithelial Cell ◽  
Surface Epithelial Cell ◽  
Ovarian Surface Epithelial Cell ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial

scholarly journals Loss of GATA6 Leads to Nuclear Deformation and Aneuploidy in Ovarian Cancer

2009 ◽  
Vol 29 (17) ◽  
pp. 4766-4777 ◽  
Author(s):  
Callinice D. Capo-chichi ◽  
Kathy Q. Cai ◽  
Joseph R. Testa ◽  
Andrew K. Godwin ◽  
Xiang-Xi Xu
Keyword(s):  
Ovarian Cancer ◽  
Nuclear Envelope ◽  
Cancer Cells ◽  
Human Cancer ◽  
Ovarian Surface Epithelium ◽  
Surface Epithelium ◽  
Ovarian Cancer Cells ◽  
Ovarian Surface ◽  
Ovarian Surface Epithelial ◽  
Ovarian Tumorigenesis

ABSTRACT A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is commonly lost in ovarian cancer, and the loss of its expression is closely associated with neoplastic transformation of the ovarian surface epithelium. In the present study, we found that reduction of GATA6 expression with small interfering RNA (siRNA) in human ovarian surface epithelial cells resulted in deformation of the nuclear envelope, failure of cytokinesis, and formation of polyploid and aneuploid cells. We further discovered that loss of the nuclear envelope protein emerin may mediate the consequences of GATA6 suppression. The nuclear phenotypes were reproduced by direct suppression of emerin with siRNA. Thus, we conclude that diminished expression of GATA6 leads to a compromised nuclear envelope that is causal for polyploidy and aneuploidy in ovarian tumorigenesis. The loss of emerin may be the basis of nuclear morphological deformation and subsequently the cause of aneuploidy in ovarian cancer cells.

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