scholarly journals Caspase‑10, matrix metalloproteinase‑9 and total laminin are correlated with the tumor malignancy of clear cell renal cell carcinoma

2018 ◽  
Author(s):  
Hua Qian ◽  
Xiaoguang Li ◽  
Wei Zhang ◽  
Liang Ma ◽  
Junfeng Sun ◽  
...  
2018 ◽  
Vol 14 (3) ◽  
pp. 17-24
Author(s):  
T. M. Cherdantseva ◽  
I. P. Bobrov ◽  
S. V. Varlamov ◽  
M. N. Myadelets ◽  
I. V. Klimachev ◽  
...  

Objective: to assess matrix metalloproteinase 9 (MMP-9)  expression in renal cell carcinoma cells and cells of intratumoral inflammatory infiltrates depending on clinical and morphological characteristics and postoperative survival.Materials and methods. We evaluated MMP-expression in 108 renal cancer tissue specimens. The intensity of immunohistochemical staining was estimated by measuring integral optical density in cytoplasm.Results. We found that the integral optical density of MMP-9 immunostaining in tumor cells and cells of intratumoral inflammatory infiltrates correlates with important prognostic factors for renal cancer, including histological type of cancer, TNM stage, tumor size, Fuhrman nuclear grade, metastasis, and 5-year postoperative survival.Conclusion. Integral optical density of MMP-9 immunostaining is an additional prognostic factor for renal cell carcinoma.


2006 ◽  
Vol 241 (1) ◽  
pp. 59-63 ◽  
Author(s):  
Yasuo Awakura ◽  
Noriyuki Ito ◽  
Eijiro Nakamura ◽  
Takeshi Takahashi ◽  
Hirokazu Kotani ◽  
...  

2003 ◽  
Vol 44 (5) ◽  
pp. 560-566 ◽  
Author(s):  
Nam Hoon Cho ◽  
Hyo Sub Shim ◽  
Sun Young Rha ◽  
Suki Hee Kang ◽  
Sung Hui Hong ◽  
...  

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