scholarly journals The expression and clinical significance of matrix metalloproteinase 7 and tissue inhibitor of matrix metalloproteinases 2 in clear cell renal cell carcinoma

2012 ◽  
Vol 5 (3) ◽  
pp. 890-896 ◽  
Author(s):  
HONGSHENG LU ◽  
ZHAOHUI YANG ◽  
HUI ZHANG ◽  
MEIFU GAN ◽  
TAO ZHOU ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Matrix Metalloproteinases ◽  
Matrix Metalloproteinase ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Tissue Inhibitor ◽  
Cell Renal Cell Carcinoma ◽  
Matrix Metalloproteinase 7

scholarly journals Downregulation of lncRNA ZNF582-AS1 due to DNA hypermethylation promotes clear cell renal cell carcinoma growth and metastasis by regulating the N(6)-methyladenosine modification of MT-RNR1

2021 ◽  
Vol 40 (1) ◽  
Author(s):  
Wuping Yang ◽  
Kenan Zhang ◽  
Lei Li ◽  
Yawei Xu ◽  
Kaifang Ma ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Renal Cell Carcinoma ◽  
Protein Expression ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Expression Level ◽  
Cell Renal Cell Carcinoma ◽  
Qrt Pcr

Abstract Background Emerging evidence confirms that lncRNAs (long non-coding RNAs) are potential biomarkers that play vital roles in tumors. ZNF582-AS1 is a novel lncRNA that serves as a potential prognostic marker of cancers. However, the specific clinical significance and molecular mechanism of ZNF582-AS1 in ccRCC (clear cell renal cell carcinoma) are unclear. Methods Expression level and clinical significance of ZNF582-AS1 were determined by TCGA-KIRC data and qRT-PCR results of 62 ccRCCs. DNA methylation status of ZNF582-AS1 promoter was examined by MSP, MassARRAY methylation and demethylation analysis. Gain-of-function experiments were conducted to investigate the biological roles of ZNF582-AS1 in the phenotype of ccRCC. The subcellular localization of ZNF582-AS1 was detected by RNA FISH. iTRAQ, RNA pull-down and RIP-qRT-PCR were used to identify the downstream targets of ZNF582-AS1. rRNA MeRIP-seq and MeRIP-qRT-PCR were utilized to examine the N(6)-methyladenosine modification status. Western blot and immunohistochemistry assays were used to determine the protein expression level. Results ZNF582-AS1 was downregulated in ccRCC, and decreased ZNF582-AS1 expression was significantly correlated with advanced tumor stage, higher pathological stage, distant metastasis and poor prognosis. Decreased ZNF582-AS1 expression was caused by DNA methylation at the CpG islands within its promoter. ZNF582-AS1 overexpression inhibited cell proliferative, migratory and invasive ability, and increased cell apoptotic rate in vitro and in vivo. Mechanistically, we found that ZNF582-AS1 overexpression suppressed the N(6)-methyladenosine modification of MT-RNR1 by reducing rRNA adenine N(6)-methyltransferase A8K0B9 protein level, resulting in the decrease of MT-RNR1 expression, followed by the inhibition of MT-CO2 protein expression. Furthermore, MT-RNR1 overexpression reversed the decreased MT-CO2 expression and phenotype inhibition of ccRCC induced by increased ZNF582-AS1 expression. Conclusions This study demonstrates for the first time that ZNF582-AS1 functions as a tumor suppressor gene in ccRCC and ZNF582-AS1 may serve as a potential biomarker and therapeutic target of ccRCC.

scholarly journals Clinical significance of Galectin-3 in clear cell renal cell carcinoma

2010 ◽  
Vol 57 (1,2) ◽  
pp. 152-157 ◽  
Author(s):  
Manabu Sakaki ◽  
Tomoharu Fukumori ◽  
Tomoya Fukawa ◽  
Essam Elsamman ◽  
Avirmed Shiirevnyamba ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Galectin 3

Expression of CD9 and CD82 in clear cell renal cell carcinoma and its clinical significance

2014 ◽  
Vol 210 (5) ◽  
pp. 285-290 ◽  
Author(s):  
Hyeong Ju Kwon ◽  
Sun Young Min ◽  
Min Jee Park ◽  
Cheol Lee ◽  
Jeong Hwan Park ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

MP44-18 CLINICAL SIGNIFICANCE OF NUTRITIONAL PROGNOSTIC INDEX IN PATIENTS WITH CLEAR CELL RENAL CELL CARCINOMA

2015 ◽  
Vol 193 (4S) ◽  
Author(s):  
Yoshio Ohno ◽  
Jun Nakashima ◽  
Makoto Ohori ◽  
Naoya Satake ◽  
Takeshi Kashima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Prognostic Index ◽  
Cell Renal Cell Carcinoma

scholarly journals Three novel hub genes and their clinical significance in clear cell renal cell carcinoma

2019 ◽  
Vol 10 (27) ◽  
pp. 6779-6791 ◽  
Author(s):  
He Xiao ◽  
Ping Chen ◽  
Guang Zeng ◽  
Deqiang Xu ◽  
Xinghuan Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Hub Genes ◽  
Cell Renal Cell Carcinoma

UP-01.180 Expression of Claudin-1 and 7 in Clear Cell Renal Cell Carcinoma and Its Clinical Significance

Urology ◽  
2011 ◽  
Vol 78 (3) ◽  
pp. S247
Author(s):  
B.H. Kim ◽  
Y.K. Kwon ◽  
H.S. Chang ◽  
C.I. Kim ◽  
C.H. Park ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Clear Cell Renal Cell Carcinoma (ccRCC) with Hemangioblastoma-like Features: A Previously Unreported Pattern of ccRCC with Possible Clinical Significance

2014 ◽  
Vol 66 (5) ◽  
pp. 806-810 ◽  
Author(s):  
Rodolfo Montironi ◽  
Antonio Lopez-Beltran ◽  
Liang Cheng ◽  
Andrea B. Galosi ◽  
Francesco Montorsi ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma

Expression and clinical significance of COMPASS family of histone methyltransferases in clear cell renal cell carcinoma

Gene ◽  
2018 ◽  
Vol 674 ◽  
pp. 31-36 ◽  
Author(s):  
Aman Kumar ◽  
Niti Kumari ◽  
Ashutosh Rai ◽  
Shrawan Kumar Singh ◽  
Nandita Kakkar ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Clinical Significance ◽  
Renal Cell ◽  
Clear Cell ◽  
Cell Renal Cell Carcinoma ◽  
Histone Methyltransferases
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