scholarly journals Quantitative DNA methylation analysis of paired box gene 1 and LIM homeobox transcription factor 1 α genes in cervical cancer

2018 ◽  
Author(s):  
Ling Xu ◽  
Jun Xu ◽  
Zheng Hu ◽  
Baohua Yang ◽  
Lifeng Wang ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Transcription Factor ◽  
Methylation Analysis ◽  
Homeobox Transcription Factor ◽  
Transcription Factor 1 ◽  
Dna Methylation Analysis

scholarly journals Cervical cancer detection by DNA methylation analysis in urine

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Barbara C. Snoek ◽  
Annina P. van Splunter ◽  
Maaike C. G. Bleeker ◽  
Maartje C. van Ruiten ◽  
Daniëlle A. M. Heideman ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Cancer Detection ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

scholarly journals CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

2014 ◽  
Vol 67 (12) ◽  
pp. 1067-1071 ◽  
Author(s):  
Lise M A De Strooper ◽  
Marjolein van Zummeren ◽  
Renske D M Steenbergen ◽  
Maaike C G Bleeker ◽  
Albertus T Hesselink ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Endometrial Cancer ◽  
Gene Promoter ◽  
Intraepithelial Neoplasia ◽  
Promoter Hypermethylation ◽  
Methylation Analysis ◽  
Cervical Intraepithelial Neoplasia Grade ◽  
Specific Pcr ◽  
Dna Methylation Analysis

AimsGene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. The current study was set out to assess the performance of CADM1, MAL and miR124-2 methylation analysis in cervical scrapes for detection of cervical and endometrial cancer.MethodsA series of cervical scrapes of women with cervical (n=79) or endometrial (n=21) cancer, cervical intraepithelial neoplasia grade 3 (CIN3) (n=16) or CIN2 (n=32), and women without evidence of CIN2 or worse (n=120) were assessed for methylation of CADM1, MAL and miR124-2. Methylation analysis was done by the PreCursor-M assay, a multiplex quantitative methylation-specific PCR.ResultsAll samples of women with cervical cancer (79/79, 100%), independent of the histotype, and 76% (16/21; 95% CI 58.0% to 94.4%) of women with endometrial cancer scored positive for DNA methylation for at least one of the three genes. In women without cancer, methylation frequencies increased significantly with severity of disease from 19.2% (23/120; 95% CI 12.1% to 26.2%) in women without CIN2 or worse to 37.5% (12/32; 95% CI 20.7% to 54.3%) and 68.8% (11/16; 95% CI 46.0% to 91.5%) in women with CIN2 and CIN3, respectively. Overall methylation positivity and the number of methylated genes increased proportionally to the lesion severity.ConclusionsDNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer and the majority of CIN3 lesions, and has the capacity to broaden its use on cervical scrapes through the detection of a substantial subset of endometrial carcinomas.

SAT0056 Dna methylation analysis identified TBX5 as an important transcription factor in rheumatoid arthritis

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 489.1-489
Author(s):  
E. Karouzakis ◽  
M. Trenkmann ◽  
F. Niederer ◽  
R.E. Gay ◽  
B.A. Michel ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Methylation ◽  
Transcription Factor ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

scholarly journals Quantitative DNA Methylation Analysis of Candidate Genes in Cervical Cancer

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0122495 ◽  
Author(s):  
Erin M. Siegel ◽  
Bridget M. Riggs ◽  
Amber L. Delmas ◽  
Abby Koch ◽  
Ardeshir Hakam ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Candidate Genes ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

scholarly journals DNA methylation analysis in liquid-based cytology for cervical cancer screening

2009 ◽  
Vol 125 (12) ◽  
pp. 2995-3002 ◽  
Author(s):  
Sophia Apostolidou ◽  
Richard Hadwin ◽  
Matthew Burnell ◽  
Allison Jones ◽  
Donna Baff ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Methylation Analysis ◽  
Liquid Based Cytology ◽  
Dna Methylation Analysis

scholarly journals P46.03 DNA Methylation Analysis in Smokers and Non-Smokers (Passive and ex-Smokers)

2021 ◽  
Vol 16 (3) ◽  
pp. S490
Author(s):  
D.M. Aguilar-Beltrán ◽  
A.G. Alcázar-Ramos ◽  
A.L. Vega-Rodríguez ◽  
D.G. García-Gutiérrez ◽  
A.D. Bertadillo-Jilote ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Methylation Analysis ◽  
Dna Methylation Analysis
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