scholarly journals DNA methylation analysis in liquid-based cytology for cervical cancer screening

2009 ◽  
Vol 125 (12) ◽  
pp. 2995-3002 ◽  
Author(s):  
Sophia Apostolidou ◽  
Richard Hadwin ◽  
Matthew Burnell ◽  
Allison Jones ◽  
Donna Baff ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Methylation Analysis ◽  
Liquid Based Cytology ◽  
Dna Methylation Analysis

A Comparison of Liquid-Based Cytology with Conventional Cytology in Cervical Cancer Screening

2012 ◽  
Vol 56 (4) ◽  
pp. 370-374 ◽  
Author(s):  
Setsu Akamatsu ◽  
Shoji Kodama ◽  
Yukari Himeji ◽  
Naomi Ikuta ◽  
Nikako Shimagaki
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cervical Cancer Screening ◽  
Conventional Cytology ◽  
Liquid Based Cytology

ConventionalPap smearand liquid based cytology for cervical cancer screening - a comparative study

2007 ◽  
Vol 24 (4) ◽  
pp. 167 ◽  
Author(s):  
RK Sherwani ◽  
T Khan ◽  
K Akhtar ◽  
A Zeba ◽  
FA Siddiqui ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Comparative Study ◽  
Cervical Cancer Screening ◽  
Liquid Based Cytology

scholarly journals Cervical cancer detection by DNA methylation analysis in urine

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Barbara C. Snoek ◽  
Annina P. van Splunter ◽  
Maaike C. G. Bleeker ◽  
Maartje C. van Ruiten ◽  
Daniëlle A. M. Heideman ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Cancer Detection ◽  
Methylation Analysis ◽  
Dna Methylation Analysis

scholarly journals Conventional pap’s test and liquid-based cytology for the screening of cervical cancer with back up colposcopy directed biopsy

2019 ◽  
Vol 12 (2) ◽  
pp. 105-108
Author(s):  
Sabera Khatun ◽  
Sayada Fatema Khatun
Keyword(s):  
Cervical Cancer ◽  
Cancer Screening ◽  
Cancer Patients ◽  
Cervical Cancer Screening ◽  
False Negative ◽  
Precancerous Lesion ◽  
True Negative ◽  
Liquid Based Cytology

The aim of this study was to screen the suspected cervical cancer patients (n=100) by liquid-based cytology and conventional pap’s smear followed by colposcopic biopsy from July 2016 to June 2017. In conventional pap’s test, 73 cases were true negative whereas 25 cases were false negative. However, in liquid-based cytology, 68 cases were true negative and 23 cases were false negative. Finally when colposcopic examinations were done, 61 cases were true negative and 15 cases were false negative. The sensitivity of liquid-based cytology was 11.5% for cervical cancer screening which was more than the conventional pap’s smear (3.8%). In conclusion, liquid-based cytology should be more preferable method than the than conventional pap’s smear for the diagnosis of precancerous lesion of the cervix.

scholarly journals CADM1, MAL and miR124-2 methylation analysis in cervical scrapes to detect cervical and endometrial cancer

2014 ◽  
Vol 67 (12) ◽  
pp. 1067-1071 ◽  
Author(s):  
Lise M A De Strooper ◽  
Marjolein van Zummeren ◽  
Renske D M Steenbergen ◽  
Maaike C G Bleeker ◽  
Albertus T Hesselink ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Dna Methylation ◽  
Endometrial Cancer ◽  
Gene Promoter ◽  
Intraepithelial Neoplasia ◽  
Promoter Hypermethylation ◽  
Methylation Analysis ◽  
Cervical Intraepithelial Neoplasia Grade ◽  
Specific Pcr ◽  
Dna Methylation Analysis

AimsGene promoter hypermethylation is recognised as an essential early step in carcinogenesis, indicating important application areas for DNA methylation analysis in early cancer detection. The current study was set out to assess the performance of CADM1, MAL and miR124-2 methylation analysis in cervical scrapes for detection of cervical and endometrial cancer.MethodsA series of cervical scrapes of women with cervical (n=79) or endometrial (n=21) cancer, cervical intraepithelial neoplasia grade 3 (CIN3) (n=16) or CIN2 (n=32), and women without evidence of CIN2 or worse (n=120) were assessed for methylation of CADM1, MAL and miR124-2. Methylation analysis was done by the PreCursor-M assay, a multiplex quantitative methylation-specific PCR.ResultsAll samples of women with cervical cancer (79/79, 100%), independent of the histotype, and 76% (16/21; 95% CI 58.0% to 94.4%) of women with endometrial cancer scored positive for DNA methylation for at least one of the three genes. In women without cancer, methylation frequencies increased significantly with severity of disease from 19.2% (23/120; 95% CI 12.1% to 26.2%) in women without CIN2 or worse to 37.5% (12/32; 95% CI 20.7% to 54.3%) and 68.8% (11/16; 95% CI 46.0% to 91.5%) in women with CIN2 and CIN3, respectively. Overall methylation positivity and the number of methylated genes increased proportionally to the lesion severity.ConclusionsDNA methylation analysis of CADM1, MAL and miR124-2 in cervical scrapes consistently detects cervical cancer and the majority of CIN3 lesions, and has the capacity to broaden its use on cervical scrapes through the detection of a substantial subset of endometrial carcinomas.

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