scholarly journals Treatment with a JNK inhibitor increases, whereas treatment with a p38 inhibitor decreases, H2O2-induced calf pulmonary arterial endothelial cell death

2017 ◽  
Vol 14 (2) ◽  
pp. 1737-1744
Author(s):  
Woo Hyun Park
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
P38 Inhibitor ◽  
Arterial Endothelial Cell ◽  
Endothelial Cell Death ◽  
Pulmonary Arterial

scholarly journals Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy

2001 ◽  
Vol 90 (6) ◽  
pp. 2279-2288 ◽  
Author(s):  
Martin H. Beauchamp ◽  
Ana Katherine Martinez-Bermudez ◽  
Fernand Gobeil ◽  
Anne Marilise Marrache ◽  
Xin Hou ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Death ◽  
Endothelial Cell ◽  
Oxidant Stress ◽  
Microvascular Endothelial Cell ◽  
Oxygen Induced Retinopathy ◽  
Rat Pups ◽  
Endothelial Cell Death ◽  
Peroxidation Product ◽  
Synthase Inhibitor

Microvascular degeneration is an important event in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity. Because oxidant stress abundantly generates thromboxane A2(TxA2), we tested whether TxA2plays a role in retinal vasoobliteration of OIR and contributes to such vascular degeneration by direct endothelial cytotoxicity. Hyperoxia-induced retinal vasoobliteration in rat pups (80% O2exposure from postnatal days 5–14) was associated with increased TxB2generation and was significantly prevented by TxA2synthase inhibitor CGS-12970 (10 mg · kg−1· day−1) or TxA2-receptor antagonist CGS-22652 (10 mg · kg−1· day−1). TxA2mimetics U-46619 (EC5050 nM) and I-BOP (EC505 nM) caused a time- and concentration-dependent cell death of neuroretinovascular endothelial cells from rats as well as newborn pigs but not of smooth muscle and astroglial cells; other prostanoids did not cause cell death. The peroxidation product 8-iso-PGF2, which is generated in OIR, stimulated TxA2formation by endothelial cells and triggered cell death; these effects were markedly diminished by CGS-12970. TxA2-dependent neuroretinovascular endothelial cell death was mostly by necrosis and to a lesser extent by apoptosis. The data identify an important role for TxA2in vasoobliteration of OIR and unveil a so far unknown function for TxA2in directly triggering neuroretinal microvascular endothelial cell death. These effects of TxA2might participate in other ischemic neurovascular injuries.

Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway

2013 ◽  
Vol 45 ◽  
pp. 21-27 ◽  
Author(s):  
Jiunn-Tay Lee ◽  
Giia-Sheun Peng ◽  
Shao-Yuan Chen ◽  
Chang-Hung Hsu ◽  
Chun-Chieh Lin ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Acid Sphingomyelinase ◽  
Cerebral Endothelial Cell ◽  
Endothelial Cell Death

NGP1-01, a multi-targeted polycyclic cage amine, attenuates brain endothelial cell death in iron overload conditions

2012 ◽  
Vol 1489 ◽  
pp. 133-139 ◽  
Author(s):  
J.A. Lockman ◽  
W.J. Geldenhuys ◽  
M.R. Jones-Higgins ◽  
J.D. Patrick ◽  
D.D. Allen ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Iron Overload ◽  
Brain Endothelial Cell ◽  
Endothelial Cell Death
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