scholarly journals Akt down regulation by CYP2C9-induced ROS generation mediate mitochondrial-dependent endothelial cell death elicited by natural antioxidants

2010 ◽  
Vol 83 (1) ◽  
Author(s):  
A. Cossu ◽  
A.M. Posadino ◽  
V. Pasciu ◽  
G. Gasparetti ◽  
S. Delogu ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Natural Antioxidants ◽  
Ros Generation ◽  
Down Regulation ◽  
Endothelial Cell Death

scholarly journals Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy

2001 ◽  
Vol 90 (6) ◽  
pp. 2279-2288 ◽  
Author(s):  
Martin H. Beauchamp ◽  
Ana Katherine Martinez-Bermudez ◽  
Fernand Gobeil ◽  
Anne Marilise Marrache ◽  
Xin Hou ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Death ◽  
Endothelial Cell ◽  
Oxidant Stress ◽  
Microvascular Endothelial Cell ◽  
Oxygen Induced Retinopathy ◽  
Rat Pups ◽  
Endothelial Cell Death ◽  
Peroxidation Product ◽  
Synthase Inhibitor

Microvascular degeneration is an important event in oxygen-induced retinopathy (OIR), a model of retinopathy of prematurity. Because oxidant stress abundantly generates thromboxane A2(TxA2), we tested whether TxA2plays a role in retinal vasoobliteration of OIR and contributes to such vascular degeneration by direct endothelial cytotoxicity. Hyperoxia-induced retinal vasoobliteration in rat pups (80% O2exposure from postnatal days 5–14) was associated with increased TxB2generation and was significantly prevented by TxA2synthase inhibitor CGS-12970 (10 mg · kg−1· day−1) or TxA2-receptor antagonist CGS-22652 (10 mg · kg−1· day−1). TxA2mimetics U-46619 (EC5050 nM) and I-BOP (EC505 nM) caused a time- and concentration-dependent cell death of neuroretinovascular endothelial cells from rats as well as newborn pigs but not of smooth muscle and astroglial cells; other prostanoids did not cause cell death. The peroxidation product 8-iso-PGF2, which is generated in OIR, stimulated TxA2formation by endothelial cells and triggered cell death; these effects were markedly diminished by CGS-12970. TxA2-dependent neuroretinovascular endothelial cell death was mostly by necrosis and to a lesser extent by apoptosis. The data identify an important role for TxA2in vasoobliteration of OIR and unveil a so far unknown function for TxA2in directly triggering neuroretinal microvascular endothelial cell death. These effects of TxA2might participate in other ischemic neurovascular injuries.

Homocysteine induces cerebral endothelial cell death by activating the acid sphingomyelinase ceramide pathway

2013 ◽  
Vol 45 ◽  
pp. 21-27 ◽  
Author(s):  
Jiunn-Tay Lee ◽  
Giia-Sheun Peng ◽  
Shao-Yuan Chen ◽  
Chang-Hung Hsu ◽  
Chun-Chieh Lin ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Acid Sphingomyelinase ◽  
Cerebral Endothelial Cell ◽  
Endothelial Cell Death

NGP1-01, a multi-targeted polycyclic cage amine, attenuates brain endothelial cell death in iron overload conditions

2012 ◽  
Vol 1489 ◽  
pp. 133-139 ◽  
Author(s):  
J.A. Lockman ◽  
W.J. Geldenhuys ◽  
M.R. Jones-Higgins ◽  
J.D. Patrick ◽  
D.D. Allen ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Iron Overload ◽  
Brain Endothelial Cell ◽  
Endothelial Cell Death

scholarly journals Carbamoylating Activity Associated with the Activation of the Antitumor Agent Laromustine Inhibits Angiogenesis by Inducing ASK1-Dependent Endothelial Cell Death

PLoS ONE ◽  
2014 ◽  
Vol 9 (7) ◽  
pp. e103224 ◽  
Author(s):  
Weidong Ji ◽  
Mei Yang ◽  
Alexandra Praggastis ◽  
Yonghao Li ◽  
Huanjiao Jenny Zhou ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Antitumor Agent ◽  
Endothelial Cell Death

scholarly journals The blood-brain barrier in primary CNS lymphomas: Ultrastructural evidence of endothelial cell death

1999 ◽  
Vol 1 (2) ◽  
pp. 89-100
Author(s):  
Peter P. Molnár ◽  
Brian P. O'Neill ◽  
Bernd W. Scheithauer ◽  
Dennis R. Groothuis
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Ultrastructural Evidence ◽  
Blood Brain ◽  
Endothelial Cell Death ◽  
Cns Lymphomas

183 Heme Oxygenase (HO)-1 Induction Prevents Endoplasmic Reticulum Stress-Mediated Endothelial Cell Death and Dysfunction

Heart ◽  
2015 ◽  
Vol 101 (Suppl 4) ◽  
pp. A103.2-A103
Author(s):  
Hatem Maamoun ◽  
Matshediso Zachariah ◽  
Fiona Green ◽  
Abdelali Agouni
Keyword(s):  
Endoplasmic Reticulum ◽  
Cell Death ◽  
Endothelial Cell ◽  
Endoplasmic Reticulum Stress ◽  
Heme Oxygenase ◽  
Endothelial Cell Death

THE BENEFICIAL EFFECT OF TAURINE ON THE PREVENTION OF HUMAN ENDOTHELIAL CELL DEATH

Shock ◽  
1996 ◽  
Vol 6 (5) ◽  
pp. 331-338 ◽  
Author(s):  
Jiang Huai Wang ◽  
H. Paul Redmond ◽  
R. William G. Watson ◽  
Claire Condron ◽  
David Bouchier-Hayes
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Beneficial Effect ◽  
Human Endothelial Cell ◽  
Endothelial Cell Death

scholarly journals Aldose reductase inhibitor, fidarestat prevents doxorubicin-induced endothelial cell death and dysfunction

2018 ◽  
Vol 150 ◽  
pp. 181-190 ◽  
Author(s):  
Himangshu Sonowal ◽  
Pabitra Pal ◽  
Kirtikar Shukla ◽  
Ashish Saxena ◽  
Satish K. Srivastava ◽  
...  
Keyword(s):  
Cell Death ◽  
Endothelial Cell ◽  
Aldose Reductase ◽  
Reductase Inhibitor ◽  
Aldose Reductase Inhibitor ◽  
Endothelial Cell Death
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