scholarly journals Anticancer activity of Nelumbo nucifera stamen extract in human colon cancer HCT-116 cells in vitro

2016 ◽  
Vol 13 (3) ◽  
pp. 1470-1478 ◽  
Author(s):  
Xin Zhao ◽  
Xia Feng ◽  
Cun Wang ◽  
Deguang Peng ◽  
Kai Zhu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
Human Colon ◽  
Nelumbo Nucifera ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells

scholarly journals Ultrasound-enhanced biosynthesis of uniform ZnO nanorice using Swietenia macrophylla seed extract and its in vitro anticancer activity

2021 ◽  
Vol 10 (1) ◽  
pp. 572-585
Author(s):  
Darren Yi Sern Low ◽  
Camille Keisha Mahendra ◽  
Janarthanan Supramaniam ◽  
Loh Teng Hern Tan ◽  
Learn Han Lee ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Hexagonal Wurtzite Structure ◽  
Colon Cancer Cells ◽  
Swietenia Macrophylla ◽  
Zno Nps ◽  
Human Colon Cancer ◽  
Hct 116

Abstract In this study, ultrasonically driven biosynthesis of zinc oxide nanoparticles (ZnO NPs) using Swietenia macrophylla seed ethyl acetate fraction (SMEAF) has been reported. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) analyses confirmed the presence of a pure hexagonal wurtzite structure of ZnO. Field emission scanning electron microscope images revealed the formation of uniquely identifiable uniform rice-shaped biologically synthesized ZnOSMEAF particles. The particle sizes of the biosynthesized NPs ranged from 262 to 311 nm. The underlying mechanisms for the biosynthesis of ZnOSMEAF under ultrasound have been proposed based on FTIR and XRD results. The anticancer activity of the as-prepared ZnOSMEAF was investigated against HCT-116 human colon cancer cell lines via methyl thiazolyl tetrazolium assay. ZnOSMEAF exhibited significant anticancer activity against colon cancer cells with higher potency than ZnO particles prepared using the chemical method and SMEAF alone. Exposure of HCT-116 colon cancer cells to ZnOSMEAF promoted a remarkable reduction in cell viability in all the tested concentrations. This study suggests that green sonochemically induced ZnO NPs using medicinal plant extract could be a potential anticancer agent for biomedical applications.

scholarly journals Development and Characterization of a Model of Liver Metastasis Using Human Colon Cancer HCT-116 Cells

2007 ◽  
Vol 30 (9) ◽  
pp. 1779-1783 ◽  
Author(s):  
Kazuhiro Ishizu ◽  
Naohide Sunose ◽  
Kanami Yamazaki ◽  
Takashi Tsuruo ◽  
Sotaro Sadahiro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells

scholarly journals Anticancer potential of an ethanol extract of Asiasari radix against HCT-116 human colon cancer cells in vitro

2012 ◽  
Vol 5 (1) ◽  
pp. 305-310 ◽  
Author(s):  
SE-MI OH ◽  
JINHEE KIM ◽  
JUN LEE ◽  
JIN-MU YI ◽  
DAL-SEOK OH ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cancer Cells ◽  
Ethanol Extract ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Human Colon Cancer Cells

scholarly journals Ellagic acid induces cell cycle arrest and apoptosis via the TGF‑β1/Smad3 signaling pathway in human colon cancer HCT‑116 cells

2020 ◽  
Vol 44 (2) ◽  
pp. 768-776 ◽  
Author(s):  
Jinlu Zhao ◽  
Guodong Li ◽  
Jiufeng Wei ◽  
Shuwei Dang ◽  
Xiaotong Yu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Ellagic Acid ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
Tgf Β1

scholarly journals Apoptotic effects of acacetin in human colon cancer HT-29 and HCT 116 cells

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Bedia Cakmakoglu ◽  
BesteTacal Aslan ◽  
Baris Ertugrul ◽  
ElifSinem Iplik
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
Apoptotic Effects ◽  
Ht 29

scholarly journals Saponins from edible spears of wild asparagus inhibit AKT, p70S6K, and ERK signalling, and induce apoptosis through G0/G1 cell cycle arrest in human colon cancer HCT-116 cells

2016 ◽  
Vol 26 ◽  
pp. 1-10 ◽  
Author(s):  
Sara Jaramillo ◽  
Francisco J.G. Muriana ◽  
Rafael Guillen ◽  
Ana Jimenez-Araujo ◽  
Rocio Rodriguez-Arcos ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Hct 116 ◽  
G1 Cell Cycle Arrest ◽  
Hct 116 Cells

scholarly journals ID: 1029 Effects of carnosine on regulation of migration and invasion in human colorectal cancer cells

2017 ◽  
Vol 4 (S) ◽  
pp. 104 ◽  
Author(s):  
Po-Yu Lai ◽  
Shu-Chen Hsieh ◽  
Chih-Chung Wu ◽  
Shu-Ling Hsieh
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
Human Colon Cancer Cells

Colorectal cancer is the third most commonly diagnosed cancer in the word. Carnosine is an endogenous dipeptide found in vertebrate skeletal muscles. It is known to have anti-fatigue, antioxidative, antihypertensive, antidiabetic, and cancer inhibiting effects. However, little research has been done regarding its influence on the metastasis of colon cancer. This study cultivated HCT-116 human colon cancer cells as a test model in order to investigate the impact of carnosine on the migration and invasion of human colon cancer cells. The results showed that 48-hour treatments of HCT-116 cells with 0.5, 1, or 5 mM carnosine each significantly inhibited the migration ability of the cells (P < 0.05). The 48-hour treatments with 0.5, 1, or 5 mM carnosine were also found to significantly reduce MMP-9 activity (P < 0.05), but not MMP-2 expression. Furthermore, when HCT-116 cells treated with 1 or 5 mM carnosine, invasion ability are significantly decreased and significantly increased E-cadherin expression (P < 0.05). On the other hand, the protein of TIMP-1, an inhibitor of MMP-9, is signification increased after 1 or 5 mM carnosine treatment (P<0.05). In addition, the u-PA protein level are significantly decreased after carnosine treatment. The results indicate that carnosine can regulate the migration and invasion by regulating MMPs and its regulator molecular expression in HCT-116 cells.

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