scholarly journals Development and Characterization of a Model of Liver Metastasis Using Human Colon Cancer HCT-116 Cells

2007 ◽  
Vol 30 (9) ◽  
pp. 1779-1783 ◽  
Author(s):  
Kazuhiro Ishizu ◽  
Naohide Sunose ◽  
Kanami Yamazaki ◽  
Takashi Tsuruo ◽  
Sotaro Sadahiro ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Liver Metastasis ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells

scholarly journals Ellagic acid induces cell cycle arrest and apoptosis via the TGF‑β1/Smad3 signaling pathway in human colon cancer HCT‑116 cells

2020 ◽  
Vol 44 (2) ◽  
pp. 768-776 ◽  
Author(s):  
Jinlu Zhao ◽  
Guodong Li ◽  
Jiufeng Wei ◽  
Shuwei Dang ◽  
Xiaotong Yu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Ellagic Acid ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
Tgf Β1

scholarly journals Apoptotic effects of acacetin in human colon cancer HT-29 and HCT 116 cells

2021 ◽  
Vol 0 (0) ◽  
pp. 0
Author(s):  
Bedia Cakmakoglu ◽  
BesteTacal Aslan ◽  
Baris Ertugrul ◽  
ElifSinem Iplik
Keyword(s):  
Colon Cancer ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
Apoptotic Effects ◽  
Ht 29

scholarly journals Saponins from edible spears of wild asparagus inhibit AKT, p70S6K, and ERK signalling, and induce apoptosis through G0/G1 cell cycle arrest in human colon cancer HCT-116 cells

2016 ◽  
Vol 26 ◽  
pp. 1-10 ◽  
Author(s):  
Sara Jaramillo ◽  
Francisco J.G. Muriana ◽  
Rafael Guillen ◽  
Ana Jimenez-Araujo ◽  
Rocio Rodriguez-Arcos ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Colon Cancer ◽  
Cell Cycle Arrest ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Cycle Arrest ◽  
Hct 116 ◽  
G1 Cell Cycle Arrest ◽  
Hct 116 Cells

scholarly journals ID: 1029 Effects of carnosine on regulation of migration and invasion in human colorectal cancer cells

2017 ◽  
Vol 4 (S) ◽  
pp. 104 ◽  
Author(s):  
Po-Yu Lai ◽  
Shu-Chen Hsieh ◽  
Chih-Chung Wu ◽  
Shu-Ling Hsieh
Keyword(s):  
Colorectal Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Human Colon ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells ◽  
Human Colon Cancer Cells

Colorectal cancer is the third most commonly diagnosed cancer in the word. Carnosine is an endogenous dipeptide found in vertebrate skeletal muscles. It is known to have anti-fatigue, antioxidative, antihypertensive, antidiabetic, and cancer inhibiting effects. However, little research has been done regarding its influence on the metastasis of colon cancer. This study cultivated HCT-116 human colon cancer cells as a test model in order to investigate the impact of carnosine on the migration and invasion of human colon cancer cells. The results showed that 48-hour treatments of HCT-116 cells with 0.5, 1, or 5 mM carnosine each significantly inhibited the migration ability of the cells (P < 0.05). The 48-hour treatments with 0.5, 1, or 5 mM carnosine were also found to significantly reduce MMP-9 activity (P < 0.05), but not MMP-2 expression. Furthermore, when HCT-116 cells treated with 1 or 5 mM carnosine, invasion ability are significantly decreased and significantly increased E-cadherin expression (P < 0.05). On the other hand, the protein of TIMP-1, an inhibitor of MMP-9, is signification increased after 1 or 5 mM carnosine treatment (P<0.05). In addition, the u-PA protein level are significantly decreased after carnosine treatment. The results indicate that carnosine can regulate the migration and invasion by regulating MMPs and its regulator molecular expression in HCT-116 cells.

Molecular mechanisms of antitumor activity of 3-(4-chlorobenyzl)-5-isopropyl-5-phenylhydantoin in human colon cancer HCT-116 cells

2021 ◽  
Vol 177 ◽  
pp. S75
Author(s):  
Ana Obradović ◽  
Miloš Matić ◽  
Branka Ognjanović ◽  
Emilija Marinković ◽  
Bojan Božić ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Antitumor Activity ◽  
Molecular Mechanisms ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells

DMPPQA, a novel angiogenesis inhibitor, induces apoptosis in human colon cancer HCT-116 cells and HUVECs

2013 ◽  
Vol 38 (3) ◽  
pp. 343-354
Author(s):  
Jie Ren ◽  
Hefei Jiang ◽  
Juan Zhao ◽  
Wenqun Xin ◽  
Yuanyuan Xu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Angiogenesis Inhibitor ◽  
Human Colon ◽  
Human Colon Cancer ◽  
Hct 116 ◽  
Hct 116 Cells
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