scholarly journals Potential role of melastatin-related transient receptor potential cation channel subfamily M gene expression in the pathogenesis of urinary bladder cancer

2016 ◽  
Vol 12 (6) ◽  
pp. 5235-5239 ◽  
Author(s):  
Gülay Güleç Ceylan ◽  
Ebru Etem Önalan ◽  
Tuncay Kuloğlu ◽  
Gülten Aydoğ ◽  
İbrahim Keleş ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Potential Role ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Urinary Bladder Cancer ◽  
M Gene ◽  
Transient Receptor

scholarly journals Potential role of transient receptor potential (TRP) channels in bladder cancer cells

2014 ◽  
Vol 64 (4) ◽  
pp. 305-314 ◽  
Author(s):  
Hideki Mizuno ◽  
Yoshiro Suzuki ◽  
Masaki Watanabe ◽  
Takaaki Sokabe ◽  
Tokunori Yamamoto ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Potential Role ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Bladder Cancer Cells ◽  
Transient Receptor

scholarly journals The role of calbindin-D28k on renal calcium and magnesium handling during treatment with loop and thiazide diuretics

2016 ◽  
Vol 310 (3) ◽  
pp. F230-F236 ◽  
Author(s):  
Chien-Te Lee ◽  
Hwee-Yeong Ng ◽  
Yueh-Ting Lee ◽  
Li-Wen Lai ◽  
Yeong-Hau H. Lien
Keyword(s):  
Gene Expression ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Thiazide Diuretics ◽  
Ca Transport ◽  
Calbindin D28k ◽  
Transient Receptor ◽  
Transport Molecules

Calbindin-D28k (CBD-28k) is a calcium binding protein located in the distal convoluted tubule (DCT) and plays an important role in active calcium transport in the kidney. Loop and thiazide diuretics affect renal Ca and Mg handling: both cause Mg wasting, but have opposite effects on Ca excretion as loop diuretics increase, but thiazides decrease, Ca excretion. To understand the role of CBD-28k in renal Ca and Mg handling in response to diuretics treatment, we investigated renal Ca and Mg excretion and gene expression of DCT Ca and Mg transport molecules in wild-type (WT) and CBD-28k knockout (KO) mice. Mice were treated with chlorothiazide (CTZ; 50 mg·kg−1·day−1) or furosemide (FSM; 30 mg·kg−1·day−1) for 3 days. To avoid volume depletion, salt was supplemented in the drinking water. Urine Ca excretion was reduced in WT, but not in KO mice, by CTZ. FSM induced similar hypercalciuria in both groups. DCT Ca transport molecules, including transient receptor potential vanilloid 5 (TRPV5), TRPV6, and CBD-9k, were upregulated by CTZ and FSM in WT, but not in KO mice. Urine Mg excretion was increased and transient receptor potential subfamily M, member 6 (TRPM6) was upregulated by both CTZ and FSM in WT and KO mice. In conclusion, CBD-28k plays an important role in gene expression of DCT Ca, but not Mg, transport molecules, which may be related to its being a Ca, but not a Mg, intracellular sensor. The lack of upregulation of DCT Ca transport molecules by thiazides in the KO mice indicates that the DCT Ca transport system is critical for Ca conservation by thiazides.

scholarly journals Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1

2021 ◽  
Vol 22 (7) ◽  
pp. 3360
Author(s):  
Mee-Ra Rhyu ◽  
Yiseul Kim ◽  
Vijay Lyall
Keyword(s):  
Transient Receptor Potential ◽  
Taste Receptor ◽  
Sensory Nerve ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Trpv1 Channels ◽  
Trigeminal Neurons ◽  
Calcitonin Gene ◽  
Transient Receptor

In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expressed in sensory nerve endings. TRPA1 and TRPV1 can also indirectly influence some, but not all, primary taste qualities via the release of substance P and calcitonin gene-related peptide (CGRP) from trigeminal neurons and their subsequent effects on CGRP receptor expressed in Type III taste receptor cells. Here, we will review the effect of some chemesthetic agonists of TRPA1 and TRPV1 and their influence on bitter, sour, and salt taste qualities.

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