The potential role of transient receptor potential type A1 as a mechanoreceptor in human periodontal ligament cells

2013 ◽  
Vol 121 (6) ◽  
pp. 538-544 ◽  
Author(s):  
Takashi Tsutsumi ◽  
Hiroshi Kajiya ◽  
Teruhisa Fukawa ◽  
Mina Sasaki ◽  
Tetsuomi Nemoto ◽  
...  
Keyword(s):  
Periodontal Ligament ◽  
Potential Role ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Periodontal Ligament Cells ◽  
Human Periodontal Ligament Cells ◽  
Potential Type ◽  
Transient Receptor

Pivotal role of Transient Receptor Potential Channels in oral physiology

2021 ◽  
Vol 28 ◽  
Author(s):  
Andreas Chalazias ◽  
Grigorios Plemmenos ◽  
Evangelos Evangeliou ◽  
Christina Piperi
Keyword(s):  
Salivary Gland ◽  
Oral Cavity ◽  
Periodontal Ligament ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Dental Pain ◽  
Temporomandibular Joints ◽  
Transient Receptor

Background: Transient Receptor Potential (TRP) Channels constitute a large family of non-selective permeable ion channels involved in the perception of environmental stimuli with a central and continuously expanding role in oral tissue homeostasis. Recent studies indicate the regulatory role of TRPs in pulp physiology, oral mucosa sensation, dental pain nociception and salivary gland secretion. This review provides an update on the diverse functions of TRP channels in the physiology of oral cavity, with emphasis on their cellular location, the underlying molecular mechanisms and clinical significance. Methods: A structured search of bibliographic databases (PubMed and MEDLINE) was performed for peer reviewed studies on TRP channels function on oral cavity physiology the last ten years. A qualitative content analysis was performed in screened papers and a critical discussion of main findings is provided. Results: TRPs expression has been detected in major cell types of the oral cavity, including odontoblasts, periodontal ligament, oral epithelial, salivary gland cells, and chondrocytes of temporomandibular joints, where they mediate signal perception and transduction of mechanical, thermal, and osmotic stimuli. They contribute to pulp physiology through dentin formation, mineralization, and periodontal ligament formation along with alveolar bone remodeling in dental pulp and periodontal ligament cells. TRPs are also involved in oral mucosa sensation, dental pain nociception, saliva secretion, swallowing reflex and temporomandibular joints' development. Conclusion: Various TRP channels regulate oral cavity homeostasis, playing an important role in the transduction of external stimuli to intracellular signals in a cell type-specific manner and presenting promising drug targets for the development of pharmacological strategies to manage oral diseases.

scholarly journals Potential role of melastatin-related transient receptor potential cation channel subfamily M gene expression in the pathogenesis of urinary bladder cancer

2016 ◽  
Vol 12 (6) ◽  
pp. 5235-5239 ◽  
Author(s):  
Gülay Güleç Ceylan ◽  
Ebru Etem Önalan ◽  
Tuncay Kuloğlu ◽  
Gülten Aydoğ ◽  
İbrahim Keleş ◽  
...  
Keyword(s):  
Gene Expression ◽  
Bladder Cancer ◽  
Urinary Bladder ◽  
Potential Role ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Urinary Bladder Cancer ◽  
M Gene ◽  
Transient Receptor

scholarly journals Potential role of transient receptor potential (TRP) channels in bladder cancer cells

2014 ◽  
Vol 64 (4) ◽  
pp. 305-314 ◽  
Author(s):  
Hideki Mizuno ◽  
Yoshiro Suzuki ◽  
Masaki Watanabe ◽  
Takaaki Sokabe ◽  
Tokunori Yamamoto ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Cells ◽  
Potential Role ◽  
Transient Receptor Potential ◽  
Trp Channels ◽  
Receptor Potential ◽  
Bladder Cancer Cells ◽  
Transient Receptor

scholarly journals Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1

2021 ◽  
Vol 22 (7) ◽  
pp. 3360
Author(s):  
Mee-Ra Rhyu ◽  
Yiseul Kim ◽  
Vijay Lyall
Keyword(s):  
Transient Receptor Potential ◽  
Taste Receptor ◽  
Sensory Nerve ◽  
Receptor Potential ◽  
Transient Receptor Potential Vanilloid ◽  
Trpv1 Channels ◽  
Trigeminal Neurons ◽  
Calcitonin Gene ◽  
Transient Receptor

In addition to the sense of taste and olfaction, chemesthesis, the sensation of irritation, pungency, cooling, warmth, or burning elicited by spices and herbs, plays a central role in food consumption. Many plant-derived molecules demonstrate their chemesthetic properties via the opening of transient receptor potential ankyrin 1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) channels. TRPA1 and TRPV1 are structurally related thermosensitive cation channels and are often co-expressed in sensory nerve endings. TRPA1 and TRPV1 can also indirectly influence some, but not all, primary taste qualities via the release of substance P and calcitonin gene-related peptide (CGRP) from trigeminal neurons and their subsequent effects on CGRP receptor expressed in Type III taste receptor cells. Here, we will review the effect of some chemesthetic agonists of TRPA1 and TRPV1 and their influence on bitter, sour, and salt taste qualities.

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