scholarly journals Testin (TES) as a candidate tumour suppressor and prognostic marker in human astrocytoma

2016 ◽  
Vol 12 (5) ◽  
pp. 3305-3311 ◽  
Author(s):  
Giedrius Steponaitis ◽  
Arunas Kazlauskas ◽  
Daina Skiriute ◽  
Indre Valiulyte ◽  
Kestutis Skauminas ◽  
...  
Keyword(s):  
Prognostic Marker ◽  
Tumour Suppressor ◽  
Human Astrocytoma ◽  
Candidate Tumour Suppressor

scholarly journals The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Praachi B. Jain ◽  
Patrícia S. Guerreiro ◽  
Sara Canato ◽  
Florence Janody
Keyword(s):  
Breast Cancer ◽  
Breast Tumour ◽  
Tissue Growth ◽  
Tumour Suppressor ◽  
Aberrant Expression ◽  
Breast Epithelial Cells ◽  
Mcf10a Cells ◽  
Resistance To Doxorubicin ◽  
Candidate Tumour Suppressor

AbstractAberrant expression of the Spectraplakin Dystonin (DST) has been observed in various cancers, including those of the breast. However, little is known about its role in carcinogenesis. In this report, we demonstrate that Dystonin is a candidate tumour suppressor in breast cancer and provide an underlying molecular mechanism. We show that in MCF10A cells, Dystonin is necessary to restrain cell growth, anchorage-independent growth, self-renewal properties and resistance to doxorubicin. Strikingly, while Dystonin maintains focal adhesion integrity, promotes cell spreading and cell-substratum adhesion, it prevents Zyxin accumulation, stabilizes LATS and restricts YAP activation. Moreover, treating DST-depleted MCF10A cells with the YAP inhibitor Verteporfin prevents their growth. In vivo, the Drosophila Dystonin Short stop also restricts tissue growth by limiting Yorkie activity. As the two Dystonin isoforms BPAG1eA and BPAG1e are necessary to inhibit the acquisition of transformed features and are both downregulated in breast tumour samples and in MCF10A cells with conditional induction of the Src proto-oncogene, they could function as the predominant Dystonin tumour suppressor variants in breast epithelial cells. Thus, their loss could deem as promising prognostic biomarkers for breast cancer.

scholarly journals RBM5/LUCA-15 — Tumour Suppression by Control of Apoptosis and the Cell Cycle?

2002 ◽  
Vol 2 ◽  
pp. 1885-1890 ◽  
Author(s):  
Mirna Mourtada-Maarabouni ◽  
Gwyn T. Williams
Keyword(s):  
Gene Locus ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Suppressor Activity ◽  
Tumour Suppression ◽  
Major Significance ◽  
Tumour Suppressor Activity ◽  
Alternatively Spliced ◽  
Candidate Tumour Suppressor

The candidate tumour suppressor gene, LUCA-15, maps to the lung cancer tumour suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts, which have been shown to function as regulators of apoptosis, a fact that may have a major significance in tumour regulation. This review highlights evidence that implicates the LUCA-15 locus in the control of apoptosis and cell proliferation, and reports observations that significantly strengthen the case for tumour suppressor activity by this gene.

scholarly journals Frequent silencing of protocadherin 17 , a candidate tumour suppressor for esophageal squamous cell carcinoma

2010 ◽  
Vol 31 (6) ◽  
pp. 1027-1036 ◽  
Author(s):  
Shigeo Haruki ◽  
Issei Imoto ◽  
Ken-ichi Kozaki ◽  
Takeshi Matsui ◽  
Hiroshi Kawachi ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Tumour Suppressor ◽  
Candidate Tumour Suppressor

BRD7 is a candidate tumour suppressor gene required for p53 function

2010 ◽  
Vol 12 (4) ◽  
pp. 380-389 ◽  
Author(s):  
Jarno Drost ◽  
Fiamma Mantovani ◽  
Francesca Tocco ◽  
Ran Elkon ◽  
Anna Comel ◽  
...  
Keyword(s):  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Candidate Tumour Suppressor

scholarly journals Prognostic significance of downregulated expression of the candidate tumour suppressor gene SASH1 in colon cancer

2006 ◽  
Vol 95 (10) ◽  
pp. 1419-1423 ◽  
Author(s):  
C Rimkus ◽  
M Martini ◽  
J Friederichs ◽  
R Rosenberg ◽  
D Doll ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Prognostic Significance ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Tumour Suppressor ◽  
Candidate Tumour Suppressor

The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis

Nature ◽  
2004 ◽  
Vol 428 (6980) ◽  
pp. 328-332 ◽  
Author(s):  
Igor Garkavtsev ◽  
Sergey V. Kozin ◽  
Olga Chernova ◽  
Lei Xu ◽  
Frank Winkler ◽  
...  
Keyword(s):  
Brain Tumour ◽  
Tumour Growth ◽  
Tumour Suppressor ◽  
Tumour Suppressor Protein ◽  
Candidate Tumour Suppressor
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