scholarly journals Genome-wide methylation analysis identifies epigenetically inactivated candidate tumour suppressor genes in renal cell carcinoma

Oncogene ◽  
2010 ◽  
Vol 30 (12) ◽  
pp. 1390-1401 ◽  
Author(s):  
M R Morris ◽  
C J Ricketts ◽  
D Gentle ◽  
F McRonald ◽  
N Carli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Methylation Analysis ◽  
Suppressor Genes ◽  
Genome Wide ◽  
Candidate Tumour Suppressor

scholarly journals Identification of candidate tumour suppressor genes frequently methylated in renal cell carcinoma

Oncogene ◽  
2010 ◽  
Vol 29 (14) ◽  
pp. 2104-2117 ◽  
Author(s):  
M R Morris ◽  
C Ricketts ◽  
D Gentle ◽  
M Abdulrahman ◽  
N Clarke ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Suppressor Genes ◽  
Candidate Tumour Suppressor

Genetic changes of the E-cadherin and APC tumour suppressor genes in clear cell renal cell carcinoma

Pathology ◽  
2004 ◽  
Vol 36 (2) ◽  
pp. 145-151 ◽  
Author(s):  
Nives Pećina-Šlaus ◽  
Koraljka Gall-Trošelj ◽  
Mario Šlaus ◽  
Krešimir Radić ◽  
Tamara Nikuševa-Martić ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Tumour Suppressor ◽  
Tumour Suppressor Genes ◽  
Cell Renal Cell Carcinoma ◽  
Suppressor Genes ◽  
Genetic Changes ◽  
E Cadherin

Abstract 74: Genome-wide DNA methylation analysis of pT1a renal cell carcinoma and renal oncocytomas

2011 ◽  
Author(s):  
Ilsiya Ibragimova ◽  
Gowrishankar Banumathy ◽  
Tahseen Al-Saleem ◽  
Robert G. Uzzo ◽  
Paul Cairns
Keyword(s):  
Dna Methylation ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Methylation Analysis ◽  
Genome Wide ◽  
Renal Oncocytomas ◽  
Dna Methylation Analysis

scholarly journals Genome-wide CpG island methylation analysis implicates novel genes in the pathogenesis of renal cell carcinoma

Epigenetics ◽  
2012 ◽  
Vol 7 (3) ◽  
pp. 278-290 ◽  
Author(s):  
Christopher J. Ricketts ◽  
Mark R. Morris ◽  
Dean Gentle ◽  
Michael Brown ◽  
Naomi Wake ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Cpg Island ◽  
Methylation Analysis ◽  
Novel Genes ◽  
Genome Wide ◽  
Cpg Island Methylation

scholarly journals Tumour suppressor gene methylation and renal cell carcinoma risk: a comprehensively systematic review and meta-analysis

2021 ◽  
Author(s):  
YuPeng Liu ◽  
Lin Ma ◽  
YuXue Zhang ◽  
ZhiGang Wu ◽  
Xiaodong Liu
Keyword(s):  
Systematic Review ◽  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Meta Analysis ◽  
Tumour Suppressor ◽  
Sensitivity Analyses ◽  
Tumour Suppressor Genes ◽  
Increased Risk ◽  
Incidence Risk

Abstract Purpose: Renal cell carcinoma (RCC) is becoming more common as a urinary system malignancy. There is a growing body of evidence supporting an important role of DNA methylation alteration involved in the initiation of RCC, but the current findings are inconsistent and controversial. Thus, we performed this systematic review and meta-analysis to comprehensively assess the associations between methylation status of tumour suppressor genes and the incidence risk of RCC. Methods: This study has been registered on PROSPERO (CRD42019130782) and was reported according to the PRISMA guidelines. We systematically searched the PubMed, EMBASE and CNKI databases for relevant studies. The effect estimates were summarized using random-effect models. Results: A total of 21 case-control studies containing 1,912 participants were included. Overall, abnormal hypermethylation of RASSF1A was associated with a significantly increased risk of RCC (OR, 6.612, 95% CI: 1.926-22.697, P = 0.003), especially in the American populations (OR, 18.429, 95% CI: 3.072-110.536, P = 0.001). An increased RCC risk was also associated with hypermethylation of SFRP1 and GSTP1 (OR, 3.995, 95% CI: 1.607-9.934, P = 0.003; OR, 4.508, 95% CI: 1.004-20.239, P = 0.049; respectively); however, the results for SFRP1 and GSTP1 were non-conclusive due to the limited number of studies included and the inconsistency across sensitivity analyses. There was no obvious association for the other genes. Conclusion: This study demonstrated a statistically and robustly positive association of aberrant hypermethylation of RASSF1A with an increased risk of developing RCC, indicating a potentially useful biomarker to predict the RCC incidence risk.

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