scholarly journals Ki-67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells

2016 ◽  
Vol 12 (4) ◽  
pp. 2641-2647 ◽  
Author(s):  
Yanxia Bai ◽  
Yuan Shao ◽  
Huajing Li ◽  
Wanli Xue ◽  
Fang Quan ◽  
...  
Keyword(s):  
Laryngeal Carcinoma ◽  
Ki 67 ◽  
Human Laryngeal Carcinoma

scholarly journals Genotoxic Effects of Green Tea Extract on Human Laryngeal Carcinoma Cells In Vitro

2011 ◽  
Vol 62 (2) ◽  
pp. 139-146 ◽  
Author(s):  
Ksenija Durgo ◽  
Sandra Kostić ◽  
Katarina Gradiški ◽  
Draženka Komes ◽  
Maja Osmak ◽  
...  
Keyword(s):  
Cell Line ◽  
Green Tea ◽  
Laryngeal Carcinoma ◽  
Resistant Cell ◽  
Resistant Cell Line ◽  
Green Tea Extract ◽  
Carcinoma Cells ◽  
Tea Extract ◽  
Human Laryngeal Carcinoma

Genotoxic Effects of Green Tea Extract on Human Laryngeal Carcinoma Cells In VitroGreen tea (Camellia sinensis) contains several bioactive compounds which protect the cell and prevent tumour development. Phytochemicals in green tea extract (mostly flavonoids) scavenge free radicals, but also induce pro-oxidative reactions in the cell. In this study, we evaluated the potential cytotoxic and prooxidative effects of green tea extract and its two main flavonoid constituents epigallocatechin gallate (EGCG) and epicatechin gallate (ECG) on human laryngeal carcinoma cell line (HEp2) and its cross-resistant cell line CK2. The aim was to see if the extract and its two flavonoids could increase the sensitivity of the cisplatin-resistant cell line CK2 in comparison to the parental cell line. The results show that EGCG and green tea extract increased the DNA damage in the CK2 cell line during short exposure. The cytotoxicity of EGCG and ECG increased with the time of incubation. Green tea extract induced lipid peroxidation in the CK2 cell line. The pro-oxidant effect of green tea was determined at concentrations higher than those found in traditionally prepared green tea infusions.

Anti-Cancer Effect of Indirubin-3'-Monoxime for Human Laryngeal Carcinoma

2009 ◽  
Vol 6 (1) ◽  
pp. 27-34
Author(s):  
K. Paulkumar ◽  
R. Arunachala ◽  
R. Kameswaran ◽  
R. Ramanibai ◽  
G. Annadurai
Keyword(s):  
Laryngeal Carcinoma ◽  
Anti Cancer ◽  
Human Laryngeal Carcinoma

scholarly journals High PINCH1 Expression in Human Laryngeal Carcinoma Associates with Poor Prognosis

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Georgios Tsinias ◽  
Sofia Nikou ◽  
Theodoros Papadas ◽  
Panagiotis Pitsos ◽  
Helen Papadaki ◽  
...  
Keyword(s):  
Actin Cytoskeleton ◽  
Focal Adhesion ◽  
Laryngeal Carcinoma ◽  
Human Cancer ◽  
Prognostic Significance ◽  
Disease Free Survival ◽  
Actin Binding ◽  
Poor Overall Survival ◽  
Altered Expression ◽  
Human Laryngeal Carcinoma

Focal adhesion signaling to actin cytoskeleton is critically implicated in cell migration and cancer invasion and metastasis. Actin-binding proteins cofilin and N-WASP regulate actin filament turnover, and focal adhesion proteins parvins and PINCH mediate integrin signaling to the actin cytoskeleton. Altered expression of these proteins has been implicated in human cancer. This study addresses their expression and prognostic significance in human laryngeal carcinoma. Protein expressions of cofilin, N-WASP, α-parvin, β-parvin, and PINCH1 were examined by immunohistochemistry in 72 human laryngeal squamous cell carcinomas. Correlations with clinicopathological data and survival were evaluated. All proteins examined were overexpressed in human laryngeal carcinomas compared to adjacent nonneoplastic epithelium. High expression of PINCH1 was associated significantly with high grade, lymph node-positive, and advanced stage disease. Moreover, high PINCH1 expression significantly associated with poor overall and disease-free survival and high cytoplasmic PINCH1 expression was shown by multivariate analysis to independently predict poor overall survival. In conclusion, we provide novel evidence that focal adhesion signaling to actin cytoskeleton is implicated in human laryngeal carcinogenesis and PINCH1 has prognostic significance in the disease.

Suppression of Survivin Expression by Short Hairpin RNA Induces Apoptosis in Human Laryngeal Carcinoma Cells

ORL ◽  
2008 ◽  
Vol 70 (3) ◽  
pp. 168-175 ◽  
Author(s):  
Xiu-mei Chen ◽  
Xin-yong Luan ◽  
Da-peng Lei ◽  
Xiao-jie Ma ◽  
Xue-xia Liu ◽  
...  
Keyword(s):  
Laryngeal Carcinoma ◽  
Survivin Expression ◽  
Short Hairpin Rna ◽  
Carcinoma Cells ◽  
Hairpin Rna ◽  
Short Hairpin ◽  
Human Laryngeal Carcinoma
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